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MTA3 metastasis associated 1 family member 3 [ Homo sapiens (human) ]

Gene ID: 57504, updated on 24-Nov-2020

Summary

Official Symbol
MTA3provided by HGNC
Official Full Name
metastasis associated 1 family member 3provided by HGNC
Primary source
HGNC:HGNC:23784
See related
Ensembl:ENSG00000057935 MIM:609050
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in brain (RPKM 6.3), ovary (RPKM 5.7) and 24 other tissues See more
Orthologs

Genomic context

See MTA3 in Genome Data Viewer
Location:
2p21
Exon count:
26
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (42494110..42802118)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (42721709..43011080)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel modifier subfamily G member 3 Neighboring gene voltage dependent anion channel 1 pseudogene 13 Neighboring gene ribosomal protein S13 pseudogene 3 Neighboring gene uncharacterized LOC105374555 Neighboring gene Sharpr-MPRA regulatory region 10188 Neighboring gene RNA, U6 small nuclear 137, pseudogene Neighboring gene oxoeicosanoid receptor 1 Neighboring gene uncharacterized LOC107985875 Neighboring gene 3-hydroxyanthranilate 3,4-dioxygenase Neighboring gene tRNA-Ile (anticodon TAT) 2-1 Neighboring gene FTO pseudogene 1 Neighboring gene CHORDC1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1266

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA polymerase II repressing transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromatin binding IEA
Inferred from Electronic Annotation
more info
 
histone deacetylase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
histone deacetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of G2/M transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of nucleic acid-templated transcription IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
NuRD complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NuRD complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
metastasis-associated protein MTA3
Names
metastasis associated gene family, member 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282755.2NP_001269684.1  metastasis-associated protein MTA3 isoform a

    See identical proteins and their annotated locations for NP_001269684.1

    Status: VALIDATED

    Source sequence(s)
    AB033092, AC025750, AK127245, AW292870, DA239202
    Consensus CDS
    CCDS62900.1
    UniProtKB/Swiss-Prot
    Q9BTC8
    UniProtKB/TrEMBL
    D6W5A2
    Related
    ENSP00000383973.1, ENST00000405592.5
    Conserved Domains (5) summary
    cd11661
    Location:214259
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:319368
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    pfam01448
    Location:94145
    ELM2; ELM2 domain
    pfam17226
    Location:404480
    MTA_R1; MTA R1 domain
    cl02608
    Location:2114
    BAH; or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur in ...
  2. NM_001282756.2NP_001269685.1  metastasis-associated protein MTA3 isoform a

    See identical proteins and their annotated locations for NP_001269685.1

    Status: VALIDATED

    Source sequence(s)
    AB033092, AW292870
    Consensus CDS
    CCDS62900.1
    UniProtKB/Swiss-Prot
    Q9BTC8
    UniProtKB/TrEMBL
    D6W5A2
    Related
    ENSP00000384249.1, ENST00000406652.5
    Conserved Domains (5) summary
    cd11661
    Location:214259
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:319368
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    pfam01448
    Location:94145
    ELM2; ELM2 domain
    pfam17226
    Location:404480
    MTA_R1; MTA R1 domain
    cl02608
    Location:2114
    BAH; or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur in ...
  3. NM_001330442.2NP_001317371.1  metastasis-associated protein MTA3 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) encodes the longest isoform (c).
    Source sequence(s)
    AC025750, AC074375, AC098824
    Consensus CDS
    CCDS82441.1
    UniProtKB/Swiss-Prot
    Q9BTC8
    Related
    ENSP00000385823.1, ENST00000405094.1
    Conserved Domains (5) summary
    cd11661
    Location:270315
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:376425
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd04709
    Location:3170
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:150201
    ELM2; ELM2 domain
    pfam17226
    Location:461537
    MTA_R1; MTA R1 domain
  4. NM_001330443.2NP_001317372.1  metastasis-associated protein MTA3 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC025750, AC074375, AC098824
    Related
    ENSP00000386763.1, ENST00000409019.5
    Conserved Domains (5) summary
    cd11661
    Location:270315
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:375424
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd04709
    Location:3170
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:150201
    ELM2; ELM2 domain
    pfam17226
    Location:460536
    MTA_R1; MTA R1 domain
  5. NM_001330444.2NP_001317373.1  metastasis-associated protein MTA3 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC025750, AC074375, AC098824
    Conserved Domains (5) summary
    smart00401
    Location:312361
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd04709
    Location:3170
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:150201
    ELM2; ELM2 domain
    pfam17226
    Location:397473
    MTA_R1; MTA R1 domain
    cl21498
    Location:234252
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
  6. NM_020744.4NP_065795.1  metastasis-associated protein MTA3 isoform b

    See identical proteins and their annotated locations for NP_065795.1

    Status: VALIDATED

    Source sequence(s)
    BC053631, CA447673, DB335600
    Consensus CDS
    CCDS46267.1
    UniProtKB/Swiss-Prot
    Q9BTC8
    Related
    ENSP00000385045.3, ENST00000407270.7
    Conserved Domains (4) summary
    cd11661
    Location:270315
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:376425
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd04709
    Location:3170
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:150201
    ELM2; ELM2 domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    42494110..42802118
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005264459.2XP_005264516.1  metastasis-associated protein MTA3 isoform X1

    See identical proteins and their annotated locations for XP_005264516.1

    Conserved Domains (5) summary
    cd11661
    Location:214259
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:320369
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    pfam01448
    Location:94145
    ELM2; ELM2 domain
    pfam17226
    Location:405481
    MTA_R1; MTA R1 domain
    cl02608
    Location:2114
    BAH; or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur in ...
  2. XM_017004562.2XP_016860051.1  metastasis-associated protein MTA3 isoform X2

    Related
    ENSP00000391455.1, ENST00000454356.5
  3. XM_024453019.1XP_024308787.1  metastasis-associated protein MTA3 isoform X1

    Conserved Domains (5) summary
    cd11661
    Location:214259
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:320369
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    pfam01448
    Location:94145
    ELM2; ELM2 domain
    pfam17226
    Location:405481
    MTA_R1; MTA R1 domain
    cl02608
    Location:2114
    BAH; or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur in ...

RNA

  1. XR_001738859.2 RNA Sequence

  2. XR_939697.3 RNA Sequence

  3. XR_001738860.2 RNA Sequence

  4. XR_001738861.2 RNA Sequence

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