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MRTFB myocardin related transcription factor B [ Homo sapiens (human) ]

Gene ID: 57496, updated on 5-Mar-2024

Summary

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Official Symbol
MRTFBprovided by HGNC
Official Full Name
myocardin related transcription factor Bprovided by HGNC
Primary source
HGNC:HGNC:29819
See related
Ensembl:ENSG00000186260 MIM:609463; AllianceGenome:HGNC:29819
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MKL2; MRTF-B; NPD001
Summary
Enables transcription coactivator activity. Involved in positive regulation of pri-miRNA transcription by RNA polymerase II and positive regulation of striated muscle tissue development. Predicted to be located in cytoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 11.0), testis (RPKM 5.1) and 24 other tissues See more
Orthologs
mouse all
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Genomic context

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See MRTFB in Genome Data Viewer
Location:
16p13.12
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (13994774..14266779)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (14032048..14304042)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (14164919..14360636)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371093 Neighboring gene uncharacterized LOC124903647 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10485 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10486 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10487 Neighboring gene ribosomal protein S26 pseudogene 52 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7223 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:14050534-14051733 Neighboring gene ERCC excision repair 4, endonuclease catalytic subunit Neighboring gene long intergenic non-protein coding RNA 2185 Neighboring gene long intergenic non-protein coding RNA 2186 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:14144523-14145135 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7226 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7227 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10489 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10490 Neighboring gene uncharacterized LOC124903783 Neighboring gene TVP23C pseudogene 2 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:14339016-14340215 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:14375643-14376144 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:14377689-14378337 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:14379019-14380016 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10491 Neighboring gene Sharpr-MPRA regulatory region 5476 Neighboring gene tRNA-Thr (anticodon CGT) 2-1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7229 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:14396656-14396816 Neighboring gene MIR193b-365a host gene Neighboring gene microRNA 193b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. De novo variants in MRTFB have gain-of-function activity in Drosophila and are associated with a novel neurodevelopmental phenotype with dysmorphic features. Andrews JC, et al. Genet Med, 2023 Jun. PMID 37013900
  2. The New Model of Snail Expression Regulation: The Role of MRTFs in Fast and Slow Endothelial-Mesenchymal Transition. Sobierajska K, et al. Int J Mol Sci, 2020 Aug 16. PMID 32824297, Free PMC Article
  3. Ectomesenchymal Chondromyxoid Tumor: A Neoplasm Characterized by Recurrent RREB1-MKL2 Fusions. Dickson BC, et al. Am J Surg Pathol, 2018 Oct. PMID 29912715, Free PMC Article
  4. Synaptic localisation of SRF coactivators, MKL1 and MKL2, and their role in dendritic spine morphology. Kaneda M, et al. Sci Rep, 2018 Jan 15. PMID 29335431, Free PMC Article
  5. Divergent Regulation of Actin Dynamics and Megakaryoblastic Leukemia-1 and -2 (Mkl1/2) by cAMP in Endothelial and Smooth Muscle Cells. Smith MC, et al. Sci Rep, 2017 Jun 16. PMID 28623279, Free PMC Article

See all (81) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. De novo variants in MRTFB have gain-of-function activity in Drosophila and are associated with a novel neurodevelopmental phenotype with dysmorphic features.
    Title: De novo variants in MRTFB have gain-of-function activity in Drosophila and are associated with a novel neurodevelopmental phenotype with dysmorphic features.
  2. Role of CRP2-MRTF interaction in functions of myofibroblasts.
    Title: Role of CRP2-MRTF interaction in functions of myofibroblasts.
  3. Oxidative Stress Enhances the TGF-beta2-RhoA-MRTF-A/B Axis in Cells Entering Endothelial-Mesenchymal Transition.
    Title: Oxidative Stress Enhances the TGF-β2-RhoA-MRTF-A/B Axis in Cells Entering Endothelial-Mesenchymal Transition.
  4. The New Model of Snail Expression Regulation: The Role of MRTFs in Fast and Slow Endothelial-Mesenchymal Transition.
    Title: The New Model of Snail Expression Regulation: The Role of MRTFs in Fast and Slow Endothelial-Mesenchymal Transition.
  5. Lower MRTFB expression levels are associated with shorter survival of patients with GI tract cancer. MRTFB targets SPDL1 and MCAM to inhibit CRC cell motility and tumor growth. Depletion of MRTFB in human CRC Cells increases cell motility and accelerates tumor growth in xenograft assays.
    Title: MRTFB suppresses colorectal cancer development through regulating SPDL1 and MCAM.
  6. Ectomesenchymal chondromyxoid tumors are characterized by an RREB1-MKL2 fusion gene.
    Title: Ectomesenchymal Chondromyxoid Tumor: A Neoplasm Characterized by Recurrent RREB1-MKL2 Fusions.
  7. These studies implicate the actin cytoskeleton and ELK3, FLI1, and MKL2 in the transcriptional control of EDNRB and increase our understanding of the plasticity of this receptor
    Title: Expression of endothelin type B receptors (EDNRB) on smooth muscle cells is controlled by MKL2, ternary complex factors, and actin dynamics.
  8. Our new data identifies and important contribution of MKL1/2 to explaining the strikingly different response of VSMCs and ECs to cAMP elevation. Elucidation of these pathways promises to identify targets for specific inhibition of VSMC migration and proliferation.
    Title: Divergent Regulation of Actin Dynamics and Megakaryoblastic Leukemia-1 and -2 (Mkl1/2) by cAMP in Endothelial and Smooth Muscle Cells.
  9. Taken together, these findings suggest that MKL1 and MKL2 are present at synapses and involved in dendritic spine maturation.
    Title: Synaptic localisation of SRF coactivators, MKL1 and MKL2, and their role in dendritic spine morphology.
  10. Study showed that MRTF-A and MRTF-B were upregulated in pancreatic cancer tissues supporting the hypothesis that both of them are oncogenes in pancreatic cancer.
    Title: The MRTF-A/B function as oncogenes in pancreatic cancer.
Submit: New GeneRIF Correction See all GeneRIFs (21)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.
EBI GWAS Catalog
Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty.
EBI GWAS Catalog
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
EBI GWAS Catalog
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
EBI GWAS Catalog
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
EBI GWAS Catalog
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
integrase gag-pol Analysis of HIV-1 proviral integration sites in antiretroviral treatment patients indicates that MKL2 gene favors HIV-1 integration for expansion and persistence of infected cells, suggesting HIV-1 IN interacts with MKL2 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ31823, FLJ45623, DKFZp686J1745

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cadherin binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coactivator activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in muscle organ development IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of miRNA transcription IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of striated muscle tissue development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in smooth muscle cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IC
Inferred by Curator
more info
 PubMed 

General protein information

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Preferred Names
myocardin-related transcription factor B
Names
CTA-276F8.1
MKL and myocardin family member 2
MKL/myocardin like 2
MKL/myocardin-like protein 2
MKL1/myocardin like 2
megakaryoblastic leukemia 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308142.2 → NP_001295071.1  myocardin-related transcription factor B isoform 1

    See identical proteins and their annotated locations for NP_001295071.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC012626, AC040173, AC130650
    Consensus CDS
    CCDS76823.1
    UniProtKB/Swiss-Prot
    Q9ULH7
    Related
    ENSP00000459626.2, ENST00000571589.6
    Conserved Domains (6) summary
    PHA03247
    Location:197 → 410
    PHA03247; large tegument protein UL36; Provisional
    pfam02037
    Location:400 → 433
    SAP; SAP domain
    pfam02755
    Location:141 → 163
    RPEL; RPEL repeat
    pfam09903
    Location:568 → 628
    DUF2130; Uncharacterized protein conserved in bacteria (DUF2130)
    cl29414
    Location:52 → 76
    RPEL; RPEL repeat
    cl41773
    Location:649 → 826
    SP1-4_N; N-terminal domain of transcription factor Specificity Proteins (SP) 1-4

  2. NM_001365411.2 → NP_001352340.1  myocardin-related transcription factor B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC012626, AC040173, AC130650
    UniProtKB/Swiss-Prot
    A6ND53, B4DGT8, Q68CT1, Q6UB16, Q86WW2, Q8N226, Q9ULH7
    Conserved Domains (5) summary
    smart00707
    Location:128 → 153
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02037
    Location:389 → 422
    SAP; SAP domain
    pfam02755
    Location:85 → 107
    RPEL; RPEL repeat
    cl26464
    Location:186 → 399
    Atrophin-1; Atrophin-1 family
    cl26585
    Location:557 → 594
    DUF2130; Uncharacterized protein conserved in bacteria (DUF2130)

  3. NM_001365412.2 → NP_001352341.1  myocardin-related transcription factor B isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC012626, AC040173, AC130650
    Conserved Domains (6) summary
    PHA03247
    Location:197 → 410
    PHA03247; large tegument protein UL36; Provisional
    pfam02037
    Location:400 → 433
    SAP; SAP domain
    pfam02755
    Location:141 → 163
    RPEL; RPEL repeat
    pfam09903
    Location:568 → 628
    DUF2130; Uncharacterized protein conserved in bacteria (DUF2130)
    cl29414
    Location:52 → 76
    RPEL; RPEL repeat
    cl41773
    Location:649 → 826
    SP1-4_N; N-terminal domain of transcription factor Specificity Proteins (SP) 1-4

  4. NM_001365413.2 → NP_001352342.1  myocardin-related transcription factor B isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC012626, AC040173, AC130650
    Conserved Domains (6) summary
    smart00707
    Location:68 → 93
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    PHA03247
    Location:126 → 339
    PHA03247; large tegument protein UL36; Provisional
    TIGR02784
    Location:121 → 203
    addA_alphas; double-strand break repair helicase AddA, alphaproteobacterial type
    pfam02037
    Location:332 → 362
    SAP; SAP domain
    pfam02755
    Location:25 → 48
    RPEL; RPEL repeat
    pfam09903
    Location:497 → 534
    DUF2130; Uncharacterized protein conserved in bacteria (DUF2130)

  5. NM_001365414.2 → NP_001352343.1  myocardin-related transcription factor B isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC012626, AC040173, AC130650
    Conserved Domains (7) summary
    smart00707
    Location:68 → 93
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02037
    Location:329 → 362
    SAP; SAP domain
    pfam02755
    Location:25 → 47
    RPEL; RPEL repeat
    cl26464
    Location:126 → 339
    Atrophin-1; Atrophin-1 family
    cl26585
    Location:497 → 534
    DUF2130; Uncharacterized protein conserved in bacteria (DUF2130)
    cl28087
    Location:538 → 725
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]
    cl28312
    Location:121 → 203
    UvrD; Superfamily I DNA or RNA helicase [Replication, recombination and repair]

  6. NM_001365415.2 → NP_001352344.1  myocardin-related transcription factor B isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC012626, AC040173, AC130650
    Consensus CDS
    CCDS92112.1
    UniProtKB/TrEMBL
    I3L2S3
    Related
    ENSP00000459879.1, ENST00000572567.5
    Conserved Domains (3) summary
    smart00707
    Location:128 → 153
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02755
    Location:85 → 107
    RPEL; RPEL repeat
    cl26464
    Location:186 → 310
    Atrophin-1; Atrophin-1 family

  7. NM_001365416.2 → NP_001352345.1  myocardin-related transcription factor B isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC012626, AC040173, AC130650
    Conserved Domains (3) summary
    smart00707
    Location:68 → 93
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02755
    Location:25 → 47
    RPEL; RPEL repeat
    cl28312
    Location:121 → 203
    UvrD; Superfamily I DNA or RNA helicase [Replication, recombination and repair]

  8. NM_001365417.3 → NP_001352346.1  myocardin-related transcription factor B isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC130650

  9. NM_001365418.3 → NP_001352347.1  myocardin-related transcription factor B isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC130650

  10. NM_001365419.3 → NP_001352348.1  myocardin-related transcription factor B isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC130650

  11. NM_001365420.3 → NP_001352349.1  myocardin-related transcription factor B isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC130650

  12. NM_001365421.3 → NP_001352350.1  myocardin-related transcription factor B isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC130650

  13. NM_014048.4 → NP_054767.3  myocardin-related transcription factor B isoform 2

    See identical proteins and their annotated locations for NP_054767.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC040173, AC130650, AY374297, BC016293
    Consensus CDS
    CCDS32391.1
    UniProtKB/Swiss-Prot
    Q9ULH7
    Related
    ENSP00000459205.1, ENST00000574045.5
    Conserved Domains (8) summary
    smart00707
    Location:139 → 164
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    PHA03247
    Location:197 → 410
    PHA03247; large tegument protein UL36; Provisional
    PRK10263
    Location:609 → 796
    PRK10263; DNA translocase FtsK; Provisional
    TIGR02784
    Location:192 → 274
    addA_alphas; double-strand break repair helicase AddA, alphaproteobacterial type
    pfam02037
    Location:403 → 433
    SAP; SAP domain
    pfam02755
    Location:96 → 119
    RPEL; RPEL repeat
    pfam09903
    Location:568 → 605
    DUF2130; Uncharacterized protein conserved in bacteria (DUF2130)
    cl29414
    Location:52 → 76
    RPEL; RPEL repeat

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    13994774..14266779
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047434393.1 → XP_047290349.1  myocardin-related transcription factor B isoform X1

  2. XM_047434392.1 → XP_047290348.1  myocardin-related transcription factor B isoform X1

  3. XM_017023501.3 → XP_016878990.1  myocardin-related transcription factor B isoform X1

    UniProtKB/Swiss-Prot
    Q9ULH7
    Conserved Domains (6) summary
    PHA03247
    Location:197 → 410
    PHA03247; large tegument protein UL36; Provisional
    pfam02037
    Location:400 → 433
    SAP; SAP domain
    pfam02755
    Location:141 → 163
    RPEL; RPEL repeat
    pfam09903
    Location:568 → 628
    DUF2130; Uncharacterized protein conserved in bacteria (DUF2130)
    cl29414
    Location:52 → 76
    RPEL; RPEL repeat
    cl41773
    Location:649 → 826
    SP1-4_N; N-terminal domain of transcription factor Specificity Proteins (SP) 1-4

  4. XM_047434402.1 → XP_047290358.1  myocardin-related transcription factor B isoform X4

    Related
    ENSP00000339086.4, ENST00000318282.9

  5. XM_047434391.1 → XP_047290347.1  myocardin-related transcription factor B isoform X1

  6. XM_047434390.1 → XP_047290346.1  myocardin-related transcription factor B isoform X1

  7. XM_047434399.1 → XP_047290355.1  myocardin-related transcription factor B isoform X3

  8. XM_005255452.4 → XP_005255509.1  myocardin-related transcription factor B isoform X1

    See identical proteins and their annotated locations for XP_005255509.1

    UniProtKB/Swiss-Prot
    Q9ULH7
    Conserved Domains (6) summary
    PHA03247
    Location:197 → 410
    PHA03247; large tegument protein UL36; Provisional
    pfam02037
    Location:400 → 433
    SAP; SAP domain
    pfam02755
    Location:141 → 163
    RPEL; RPEL repeat
    pfam09903
    Location:568 → 628
    DUF2130; Uncharacterized protein conserved in bacteria (DUF2130)
    cl29414
    Location:52 → 76
    RPEL; RPEL repeat
    cl41773
    Location:649 → 826
    SP1-4_N; N-terminal domain of transcription factor Specificity Proteins (SP) 1-4

  9. XM_006720914.3 → XP_006720977.1  myocardin-related transcription factor B isoform X4

    See identical proteins and their annotated locations for XP_006720977.1

    UniProtKB/Swiss-Prot
    Q9ULH7
    Conserved Domains (8) summary
    smart00707
    Location:139 → 164
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    PHA03247
    Location:197 → 410
    PHA03247; large tegument protein UL36; Provisional
    PRK10263
    Location:609 → 796
    PRK10263; DNA translocase FtsK; Provisional
    TIGR02784
    Location:192 → 274
    addA_alphas; double-strand break repair helicase AddA, alphaproteobacterial type
    pfam02037
    Location:403 → 433
    SAP; SAP domain
    pfam02755
    Location:96 → 119
    RPEL; RPEL repeat
    pfam09903
    Location:568 → 605
    DUF2130; Uncharacterized protein conserved in bacteria (DUF2130)
    cl29414
    Location:52 → 76
    RPEL; RPEL repeat

  10. XM_047434398.1 → XP_047290354.1  myocardin-related transcription factor B isoform X3

  11. XM_047434405.1 → XP_047290361.1  myocardin-related transcription factor B isoform X7

  12. XM_006720909.5 → XP_006720972.1  myocardin-related transcription factor B isoform X1

    See identical proteins and their annotated locations for XP_006720972.1

    UniProtKB/Swiss-Prot
    Q9ULH7
    Conserved Domains (6) summary
    PHA03247
    Location:197 → 410
    PHA03247; large tegument protein UL36; Provisional
    pfam02037
    Location:400 → 433
    SAP; SAP domain
    pfam02755
    Location:141 → 163
    RPEL; RPEL repeat
    pfam09903
    Location:568 → 628
    DUF2130; Uncharacterized protein conserved in bacteria (DUF2130)
    cl29414
    Location:52 → 76
    RPEL; RPEL repeat
    cl41773
    Location:649 → 826
    SP1-4_N; N-terminal domain of transcription factor Specificity Proteins (SP) 1-4

  13. XM_011522568.3 → XP_011520870.1  myocardin-related transcription factor B isoform X1

    See identical proteins and their annotated locations for XP_011520870.1

    UniProtKB/Swiss-Prot
    Q9ULH7
    Conserved Domains (6) summary
    PHA03247
    Location:197 → 410
    PHA03247; large tegument protein UL36; Provisional
    pfam02037
    Location:400 → 433
    SAP; SAP domain
    pfam02755
    Location:141 → 163
    RPEL; RPEL repeat
    pfam09903
    Location:568 → 628
    DUF2130; Uncharacterized protein conserved in bacteria (DUF2130)
    cl29414
    Location:52 → 76
    RPEL; RPEL repeat
    cl41773
    Location:649 → 826
    SP1-4_N; N-terminal domain of transcription factor Specificity Proteins (SP) 1-4

  14. XM_047434400.1 → XP_047290356.1  myocardin-related transcription factor B isoform X3

  15. XM_047434403.1 → XP_047290359.1  myocardin-related transcription factor B isoform X4

  16. XM_047434397.1 → XP_047290353.1  myocardin-related transcription factor B isoform X1

  17. XM_047434394.1 → XP_047290350.1  myocardin-related transcription factor B isoform X1

  18. XM_047434395.1 → XP_047290351.1  myocardin-related transcription factor B isoform X1

  19. XM_017023502.1 → XP_016878991.1  myocardin-related transcription factor B isoform X1

    UniProtKB/Swiss-Prot
    Q9ULH7
    Conserved Domains (6) summary
    PHA03247
    Location:197 → 410
    PHA03247; large tegument protein UL36; Provisional
    pfam02037
    Location:400 → 433
    SAP; SAP domain
    pfam02755
    Location:141 → 163
    RPEL; RPEL repeat
    pfam09903
    Location:568 → 628
    DUF2130; Uncharacterized protein conserved in bacteria (DUF2130)
    cl29414
    Location:52 → 76
    RPEL; RPEL repeat
    cl41773
    Location:649 → 826
    SP1-4_N; N-terminal domain of transcription factor Specificity Proteins (SP) 1-4

  20. XM_047434396.1 → XP_047290352.1  myocardin-related transcription factor B isoform X1

  21. XM_047434401.1 → XP_047290357.1  myocardin-related transcription factor B isoform X3

  22. XM_017023503.3 → XP_016878992.1  myocardin-related transcription factor B isoform X2

    Conserved Domains (7) summary
    smart00707
    Location:102 → 127
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    PHA03247
    Location:160 → 373
    PHA03247; large tegument protein UL36; Provisional
    TIGR02784
    Location:155 → 237
    addA_alphas; double-strand break repair helicase AddA, alphaproteobacterial type
    pfam02037
    Location:366 → 396
    SAP; SAP domain
    pfam02755
    Location:59 → 82
    RPEL; RPEL repeat
    pfam09903
    Location:531 → 568
    DUF2130; Uncharacterized protein conserved in bacteria (DUF2130)
    cl29414
    Location:15 → 39
    RPEL; RPEL repeat

  23. XM_017023504.2 → XP_016878993.1  myocardin-related transcription factor B isoform X5

    Conserved Domains (6) summary
    smart00707
    Location:128 → 153
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    PHA03247
    Location:186 → 399
    PHA03247; large tegument protein UL36; Provisional
    PRK10263
    Location:598 → 785
    PRK10263; DNA translocase FtsK; Provisional
    pfam02037
    Location:392 → 422
    SAP; SAP domain
    pfam02755
    Location:85 → 108
    RPEL; RPEL repeat
    pfam09903
    Location:557 → 594
    DUF2130; Uncharacterized protein conserved in bacteria (DUF2130)

  24. XM_047434404.1 → XP_047290360.1  myocardin-related transcription factor B isoform X6

  25. XM_011522569.3 → XP_011520871.1  myocardin-related transcription factor B isoform X6

    See identical proteins and their annotated locations for XP_011520871.1

    Conserved Domains (6) summary
    smart00707
    Location:68 → 93
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    PHA03247
    Location:126 → 339
    PHA03247; large tegument protein UL36; Provisional
    TIGR02784
    Location:121 → 203
    addA_alphas; double-strand break repair helicase AddA, alphaproteobacterial type
    pfam02037
    Location:332 → 362
    SAP; SAP domain
    pfam02755
    Location:25 → 48
    RPEL; RPEL repeat
    pfam09903
    Location:497 → 534
    DUF2130; Uncharacterized protein conserved in bacteria (DUF2130)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    14032048..14304042
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054313537.1 → XP_054169512.1  myocardin-related transcription factor B isoform X1

  2. XM_054313536.1 → XP_054169511.1  myocardin-related transcription factor B isoform X1

  3. XM_054313538.1 → XP_054169513.1  myocardin-related transcription factor B isoform X1

  4. XM_054313553.1 → XP_054169528.1  myocardin-related transcription factor B isoform X4

  5. XM_054313535.1 → XP_054169510.1  myocardin-related transcription factor B isoform X1

  6. XM_054313545.1 → XP_054169520.1  myocardin-related transcription factor B isoform X1

  7. XM_054313549.1 → XP_054169524.1  myocardin-related transcription factor B isoform X3

  8. XM_054313543.1 → XP_054169518.1  myocardin-related transcription factor B isoform X1

  9. XM_054313552.1 → XP_054169527.1  myocardin-related transcription factor B isoform X4

  10. XM_054313548.1 → XP_054169523.1  myocardin-related transcription factor B isoform X3

  11. XM_054313558.1 → XP_054169533.1  myocardin-related transcription factor B isoform X7

  12. XM_054313534.1 → XP_054169509.1  myocardin-related transcription factor B isoform X1

  13. XM_054313539.1 → XP_054169514.1  myocardin-related transcription factor B isoform X1

  14. XM_054313550.1 → XP_054169525.1  myocardin-related transcription factor B isoform X3

  15. XM_054313554.1 → XP_054169529.1  myocardin-related transcription factor B isoform X4

  16. XM_054313546.1 → XP_054169521.1  myocardin-related transcription factor B isoform X1

  17. XM_054313540.1 → XP_054169515.1  myocardin-related transcription factor B isoform X1

  18. XM_054313542.1 → XP_054169517.1  myocardin-related transcription factor B isoform X1

  19. XM_054313541.1 → XP_054169516.1  myocardin-related transcription factor B isoform X1

  20. XM_054313544.1 → XP_054169519.1  myocardin-related transcription factor B isoform X1

  21. XM_054313551.1 → XP_054169526.1  myocardin-related transcription factor B isoform X3

  22. XM_054313547.1 → XP_054169522.1  myocardin-related transcription factor B isoform X2

  23. XM_054313555.1 → XP_054169530.1  myocardin-related transcription factor B isoform X5

  24. XM_054313557.1 → XP_054169532.1  myocardin-related transcription factor B isoform X6

  25. XM_054313556.1 → XP_054169531.1  myocardin-related transcription factor B isoform X6

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ULH7.3 GenPept UniProtKB/Swiss-Prot:Q9ULH7

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