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RIMKLB ribosomal modification protein rimK like family member B [ Homo sapiens (human) ]

Gene ID: 57494, updated on 13-Mar-2020

Summary

Official Symbol
RIMKLBprovided by HGNC
Official Full Name
ribosomal modification protein rimK like family member Bprovided by HGNC
Primary source
HGNC:HGNC:29228
See related
Ensembl:ENSG00000166532 MIM:614054
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NAAGS; FAM80B; NAAGS-I
Expression
Broad expression in endometrium (RPKM 13.9), testis (RPKM 12.3) and 23 other tissues See more
Orthologs

Genomic context

See RIMKLB in Genome Data Viewer
Location:
12p13.31
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (8681600..8783095)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (8834273..8935688)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene microfibril associated protein 5 Neighboring gene Fanconi anemia core complex-associated protein 24-like Neighboring gene ribosomal protein SA pseudogene 51 Neighboring gene alpha-2-macroglobulin like 1 Neighboring gene polyhomeotic homolog 1 Neighboring gene mannose-6-phosphate receptor, cation dependent

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1238

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
N-acetyl-L-aspartate-L-glutamate ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
N-acetyl-L-aspartate-L-glutamate ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
citrate-L-glutamate ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
ligase activity, forming carbon-nitrogen bonds IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cellular amino acid biosynthetic process TAS
Traceable Author Statement
more info
 
cellular protein modification process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
beta-citrylglutamate synthase B
Names
N-acetyl-aspartyl-glutamate synthetase B
N-acetyl-aspartylglutamate synthetase B
N-acetylaspartyl-glutamate synthetase B
NAAG synthetase B
beta-citryl-glutamate synthase B
family with sequence similarity 80, member B
ribosomal protein S6 modification-like protein B
NP_001284705.1
NP_001339196.1
NP_001339197.1
NP_001339198.1
NP_001339199.1
NP_001339200.1
NP_065785.2
XP_011519092.1
XP_016875172.1
XP_016875173.1
XP_016875174.1
XP_016875175.1
XP_016875176.1
XP_024304853.1
XP_024304854.1
XP_024304855.1
XP_024304856.1
XP_024304857.1
XP_024304858.1
XP_024304859.1
XP_024304860.1
XP_024304861.1
XP_024304862.1
XP_024304863.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001297776.2NP_001284705.1  beta-citrylglutamate synthase B

    See identical proteins and their annotated locations for NP_001284705.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC092490
    Consensus CDS
    CCDS41748.1
    UniProtKB/Swiss-Prot
    Q9ULI2
    Related
    ENSP00000445863.1, ENST00000535829.6
    Conserved Domains (1) summary
    TIGR00768
    Location:8303
    rimK_fam; alpha-L-glutamate ligase, RimK family
  2. NM_001352267.1NP_001339196.1  beta-citrylglutamate synthase B

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) encodes the same protein as variants 1, 2, and 5-8.
    Source sequence(s)
    AB033064, AC092490
    Consensus CDS
    CCDS41748.1
    Conserved Domains (1) summary
    TIGR00768
    Location:8303
    rimK_fam; alpha-L-glutamate ligase, RimK family
  3. NM_001352268.1NP_001339197.1  beta-citrylglutamate synthase B

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) encodes the same protein as variants 1, 2, 4, and 6-8.
    Source sequence(s)
    AB033064, AC092490
    Consensus CDS
    CCDS41748.1
    Conserved Domains (1) summary
    TIGR00768
    Location:8303
    rimK_fam; alpha-L-glutamate ligase, RimK family
  4. NM_001352269.1NP_001339198.1  beta-citrylglutamate synthase B

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) encodes the same protein as variants 1, 2, 4, 5, 7, and 8.
    Source sequence(s)
    AB033064, AC092490
    Consensus CDS
    CCDS41748.1
    Conserved Domains (1) summary
    TIGR00768
    Location:8303
    rimK_fam; alpha-L-glutamate ligase, RimK family
  5. NM_001352270.1NP_001339199.1  beta-citrylglutamate synthase B

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) encodes the same protein as variants 1, 2, 4-6, and 8.
    Source sequence(s)
    AB033064, AC092490
    Consensus CDS
    CCDS41748.1
    Conserved Domains (1) summary
    TIGR00768
    Location:8303
    rimK_fam; alpha-L-glutamate ligase, RimK family
  6. NM_001352271.1NP_001339200.1  beta-citrylglutamate synthase B

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) encodes the same protein as variants 1, 2, and 4-7.
    Source sequence(s)
    AB033064, AC092490
    Consensus CDS
    CCDS41748.1
    Conserved Domains (1) summary
    TIGR00768
    Location:8303
    rimK_fam; alpha-L-glutamate ligase, RimK family
  7. NM_020734.4NP_065785.2  beta-citrylglutamate synthase B

    See identical proteins and their annotated locations for NP_065785.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the functional protein. All of the protein-coding variants encode the same protein.
    Source sequence(s)
    AB033064, AC092490
    Consensus CDS
    CCDS41748.1
    UniProtKB/Swiss-Prot
    Q9ULI2
    Related
    ENSP00000350136.3, ENST00000357529.7
    Conserved Domains (1) summary
    TIGR00768
    Location:8303
    rimK_fam; alpha-L-glutamate ligase, RimK family

RNA

  1. NR_123740.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' and 3' structures compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC092490
  2. NR_147945.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC092490
  3. NR_147946.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC092490
  4. NR_147947.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC092490
  5. NR_147948.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC092490
  6. NR_147949.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC092490
  7. NR_147950.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC092490

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    8681600..8783095
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017019684.1XP_016875173.1  beta-citrylglutamate synthase B isoform X1

    UniProtKB/Swiss-Prot
    Q9ULI2
    Conserved Domains (1) summary
    TIGR00768
    Location:8303
    rimK_fam; alpha-L-glutamate ligase, RimK family
  2. XM_017019686.1XP_016875175.1  beta-citrylglutamate synthase B isoform X1

    UniProtKB/Swiss-Prot
    Q9ULI2
    Conserved Domains (1) summary
    TIGR00768
    Location:8303
    rimK_fam; alpha-L-glutamate ligase, RimK family
  3. XM_011520790.1XP_011519092.1  beta-citrylglutamate synthase B isoform X2

    See identical proteins and their annotated locations for XP_011519092.1

    UniProtKB/Swiss-Prot
    Q9ULI2
    Conserved Domains (1) summary
    TIGR00768
    Location:8282
    rimK_fam; alpha-L-glutamate ligase, RimK family
  4. XM_017019683.1XP_016875172.1  beta-citrylglutamate synthase B isoform X1

    UniProtKB/Swiss-Prot
    Q9ULI2
    Conserved Domains (1) summary
    TIGR00768
    Location:8303
    rimK_fam; alpha-L-glutamate ligase, RimK family
  5. XM_017019685.2XP_016875174.1  beta-citrylglutamate synthase B isoform X1

    UniProtKB/Swiss-Prot
    Q9ULI2
    Conserved Domains (1) summary
    TIGR00768
    Location:8303
    rimK_fam; alpha-L-glutamate ligase, RimK family
  6. XM_017019687.1XP_016875176.1  beta-citrylglutamate synthase B isoform X1

    UniProtKB/Swiss-Prot
    Q9ULI2
    Conserved Domains (1) summary
    TIGR00768
    Location:8303
    rimK_fam; alpha-L-glutamate ligase, RimK family
  7. XM_024449091.1XP_024304859.1  beta-citrylglutamate synthase B isoform X1

    Conserved Domains (1) summary
    TIGR00768
    Location:8303
    rimK_fam; alpha-L-glutamate ligase, RimK family
  8. XM_024449090.1XP_024304858.1  beta-citrylglutamate synthase B isoform X1

    Conserved Domains (1) summary
    TIGR00768
    Location:8303
    rimK_fam; alpha-L-glutamate ligase, RimK family
  9. XM_024449095.1XP_024304863.1  beta-citrylglutamate synthase B isoform X3

    Conserved Domains (1) summary
    cl27318
    Location:8281
    RimK; Glutathione synthase/RimK-type ligase, ATP-grasp superfamily [Coenzyme transport and metabolism, Translation, ribosomal structure and biogenesis]
  10. XM_024449092.1XP_024304860.1  beta-citrylglutamate synthase B isoform X2

    Conserved Domains (1) summary
    TIGR00768
    Location:8282
    rimK_fam; alpha-L-glutamate ligase, RimK family
  11. XM_024449094.1XP_024304862.1  beta-citrylglutamate synthase B isoform X2

    Conserved Domains (1) summary
    TIGR00768
    Location:8282
    rimK_fam; alpha-L-glutamate ligase, RimK family
  12. XM_024449086.1XP_024304854.1  beta-citrylglutamate synthase B isoform X1

    Conserved Domains (1) summary
    TIGR00768
    Location:8303
    rimK_fam; alpha-L-glutamate ligase, RimK family
  13. XM_024449087.1XP_024304855.1  beta-citrylglutamate synthase B isoform X1

    Conserved Domains (1) summary
    TIGR00768
    Location:8303
    rimK_fam; alpha-L-glutamate ligase, RimK family
  14. XM_024449085.1XP_024304853.1  beta-citrylglutamate synthase B isoform X1

    Conserved Domains (1) summary
    TIGR00768
    Location:8303
    rimK_fam; alpha-L-glutamate ligase, RimK family
  15. XM_024449089.1XP_024304857.1  beta-citrylglutamate synthase B isoform X1

    Conserved Domains (1) summary
    TIGR00768
    Location:8303
    rimK_fam; alpha-L-glutamate ligase, RimK family
  16. XM_024449088.1XP_024304856.1  beta-citrylglutamate synthase B isoform X1

    Conserved Domains (1) summary
    TIGR00768
    Location:8303
    rimK_fam; alpha-L-glutamate ligase, RimK family
  17. XM_024449093.1XP_024304861.1  beta-citrylglutamate synthase B isoform X2

    Related
    ENSP00000483871.1, ENST00000619374.4
    Conserved Domains (1) summary
    TIGR00768
    Location:8282
    rimK_fam; alpha-L-glutamate ligase, RimK family
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