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CRACD capping protein inhibiting regulator of actin dynamics [ Homo sapiens (human) ]

Gene ID: 57482, updated on 4-Jul-2021

Summary

Official Symbol
CRACDprovided by HGNC
Official Full Name
capping protein inhibiting regulator of actin dynamicsprovided by HGNC
Primary source
HGNC:HGNC:29219
See related
Ensembl:ENSG00000109265 MIM:618327
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CRAD; KIAA1211
Expression
Biased expression in testis (RPKM 12.2), small intestine (RPKM 8.0) and 13 other tissues See more
Orthologs
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Genomic context

See CRACD in Genome Data Viewer
Location:
4q12
Exon count:
18
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (56049098..56330622)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (57036361..57196890)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377663 Neighboring gene exocyst complex component 1 Neighboring gene centrosomal protein 135 Neighboring gene VISTA enhancer hs1651 Neighboring gene RNA, 5S ribosomal pseudogene 161 Neighboring gene uncharacterized LOC101928760 Neighboring gene uncharacterized LOC105377664 Neighboring gene RNA, U6 small nuclear 197, pseudogene Neighboring gene mitochondrial ribosomal protein L22 pseudogene 1 Neighboring gene RNA, 5S ribosomal pseudogene 162 Neighboring gene ribosomal protein L7a pseudogene 31 Neighboring gene aminoadipate-semialdehyde dehydrogenase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp564H1363

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
capping protein-inhibiting regulator of actin dynamics; capping protein inhibiting regulator of actin dynamics
Names
cancer-related regulator of actin dynamics

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001393381.1NP_001380310.1  capping protein-inhibiting regulator of actin dynamics isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC022267, AC068620, AC092627
    Related
    ENSP00000507165.1, ENST00000682029.1
    Conserved Domains (4) summary
    PTZ00121
    Location:219526
    PTZ00121; MAEBL; Provisional
    PHA03247
    Location:6231060
    PHA03247; large tegument protein UL36; Provisional
    PRK10811
    Location:9341217
    rne; ribonuclease E; Reviewed
    pfam15262
    Location:45172
    DUF4592; Domain of unknown function (DUF4592)
  2. NM_001393382.1NP_001380311.1  capping protein-inhibiting regulator of actin dynamics isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC022267, AC068620
    Related
    ENSP00000423366.1, ENST00000504228.6
    Conserved Domains (4) summary
    PTZ00121
    Location:219526
    PTZ00121; MAEBL; Provisional
    PHA03247
    Location:6231060
    PHA03247; large tegument protein UL36; Provisional
    PRK10811
    Location:9341217
    rne; ribonuclease E; Reviewed
    pfam15262
    Location:45172
    DUF4592; Domain of unknown function (DUF4592)
  3. NM_001393383.1NP_001380312.1  capping protein-inhibiting regulator of actin dynamics isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC022267, AC068620, AC092627
    Conserved Domains (4) summary
    PTZ00121
    Location:161468
    PTZ00121; MAEBL; Provisional
    PHA03247
    Location:5651002
    PHA03247; large tegument protein UL36; Provisional
    PRK10811
    Location:8761159
    rne; ribonuclease E; Reviewed
    pfam15262
    Location:3114
    DUF4592; Domain of unknown function (DUF4592)
  4. NM_001393384.1NP_001380313.1  capping protein-inhibiting regulator of actin dynamics isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC022267, AC068620, AC092627
    Conserved Domains (4) summary
    PTZ00121
    Location:161468
    PTZ00121; MAEBL; Provisional
    PHA03247
    Location:5651002
    PHA03247; large tegument protein UL36; Provisional
    PRK10811
    Location:8761159
    rne; ribonuclease E; Reviewed
    pfam15262
    Location:3114
    DUF4592; Domain of unknown function (DUF4592)
  5. NM_001393385.1NP_001380314.1  capping protein-inhibiting regulator of actin dynamics isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC022267, AC068620
    Conserved Domains (4) summary
    PTZ00121
    Location:161468
    PTZ00121; MAEBL; Provisional
    PHA03247
    Location:5651002
    PHA03247; large tegument protein UL36; Provisional
    PRK10811
    Location:8761159
    rne; ribonuclease E; Reviewed
    pfam15262
    Location:3114
    DUF4592; Domain of unknown function (DUF4592)
  6. NM_020722.2NP_065773.1  capping protein-inhibiting regulator of actin dynamics isoform 1

    See identical proteins and their annotated locations for NP_065773.1

    Status: VALIDATED

    Source sequence(s)
    AC022267, AC068620
    Consensus CDS
    CCDS43230.1
    UniProtKB/Swiss-Prot
    Q6ZU35
    Related
    ENSP00000264229.6, ENST00000264229.11
    Conserved Domains (4) summary
    PTZ00121
    Location:219526
    PTZ00121; MAEBL; Provisional
    PHA03247
    Location:6231060
    PHA03247; large tegument protein UL36; Provisional
    PRK10811
    Location:9341217
    rne; ribonuclease E; Reviewed
    pfam15262
    Location:45172
    DUF4592; Domain of unknown function (DUF4592)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    56049098..56330622
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024454159.1XP_024309927.1  capping protein inhibiting regulator of actin dynamics isoform X1

    Conserved Domains (4) summary
    PTZ00121
    Location:219526
    PTZ00121; MAEBL; Provisional
    PHA03247
    Location:6231060
    PHA03247; large tegument protein UL36; Provisional
    PRK10811
    Location:9341217
    rne; ribonuclease E; Reviewed
    pfam15262
    Location:45172
    DUF4592; Domain of unknown function (DUF4592)
  2. XM_005265752.2XP_005265809.1  capping protein inhibiting regulator of actin dynamics isoform X1

    See identical proteins and their annotated locations for XP_005265809.1

    UniProtKB/Swiss-Prot
    Q6ZU35
    Conserved Domains (4) summary
    PTZ00121
    Location:219526
    PTZ00121; MAEBL; Provisional
    PHA03247
    Location:6231060
    PHA03247; large tegument protein UL36; Provisional
    PRK10811
    Location:9341217
    rne; ribonuclease E; Reviewed
    pfam15262
    Location:45172
    DUF4592; Domain of unknown function (DUF4592)
  3. XM_017008473.1XP_016863962.1  capping protein inhibiting regulator of actin dynamics isoform X2

    Related
    ENSP00000444006.1, ENST00000541073.5
    Conserved Domains (4) summary
    PTZ00121
    Location:219526
    PTZ00121; MAEBL; Provisional
    PHA03247
    Location:6231060
    PHA03247; large tegument protein UL36; Provisional
    PRK10811
    Location:9341217
    rne; ribonuclease E; Reviewed
    pfam15262
    Location:45172
    DUF4592; Domain of unknown function (DUF4592)
  4. XM_005265756.2XP_005265813.1  capping protein inhibiting regulator of actin dynamics isoform X5

    Conserved Domains (4) summary
    PTZ00121
    Location:129436
    PTZ00121; MAEBL; Provisional
    PHA03247
    Location:533970
    PHA03247; large tegument protein UL36; Provisional
    PRK10811
    Location:8441127
    rne; ribonuclease E; Reviewed
    pfam15262
    Location:282
    DUF4592; Domain of unknown function (DUF4592)
  5. XM_006714045.2XP_006714108.1  capping protein inhibiting regulator of actin dynamics isoform X6

    Conserved Domains (4) summary
    PTZ00121
    Location:105412
    PTZ00121; MAEBL; Provisional
    PHA03247
    Location:509946
    PHA03247; large tegument protein UL36; Provisional
    PRK10811
    Location:8201103
    rne; ribonuclease E; Reviewed
    pfam15262
    Location:558
    DUF4592; Domain of unknown function (DUF4592)
  6. XM_005265755.2XP_005265812.1  capping protein inhibiting regulator of actin dynamics isoform X4

    Conserved Domains (4) summary
    PTZ00121
    Location:137444
    PTZ00121; MAEBL; Provisional
    PHA03247
    Location:541978
    PHA03247; large tegument protein UL36; Provisional
    PRK10811
    Location:8521135
    rne; ribonuclease E; Reviewed
    pfam15262
    Location:1390
    DUF4592; Domain of unknown function (DUF4592)
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