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PLEKHG1 pleckstrin homology and RhoGEF domain containing G1 [ Homo sapiens (human) ]

Gene ID: 57480, updated on 9-Jun-2025
Official Symbol
PLEKHG1provided by HGNC
Official Full Name
pleckstrin homology and RhoGEF domain containing G1provided by HGNC
Primary source
HGNC:HGNC:20884
See related
Ensembl:ENSG00000120278 MIM:620134; AllianceGenome:HGNC:20884
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARHGEF41
Summary
Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in regulation of small GTPase mediated signal transduction. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jun 2025]
Expression
Broad expression in spleen (RPKM 8.2), lymph node (RPKM 3.6) and 21 other tissues See more
Orthologs
NEW
Try the new Gene table
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See PLEKHG1 in Genome Data Viewer
Location:
6q25.1
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (150599885..150843665)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (151800395..152044215)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (150921021..151164801)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene alpha-methylacyl-CoA racemase pseudogene Neighboring gene uncharacterized LOC124901429 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17677 Neighboring gene Sharpr-MPRA regulatory region 13910 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17679 Neighboring gene PLEKHG1 intron CAGE-defined B cell enhancer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25273 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25274 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25275 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25276 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17680 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:151037941-151038716 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:151038717-151039492 Neighboring gene uncharacterized LOC124901430 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:151063629-151064129 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:151063128-151063628 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:151074197-151074698 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25277 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25278 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:151169980-151171179 Neighboring gene uncharacterized LOC124901431 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:151177675-151178874 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17681 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17682 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17683 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17684 Neighboring gene PDCL3 pseudogene 5 Neighboring gene methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:151227577-151228082 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:151243887-151244135 Neighboring gene ARF like GTPase 4A pseudogene 5

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EBI GWAS Catalog

Description
Genome-wide association analysis of blood-pressure traits in African-ancestry individuals reveals common associated genes in African and non-African populations.
EBI GWAS Catalog
Genome-wide association study of panic disorder in the Japanese population.
EBI GWAS Catalog
Genome-wide association study of the rate of cognitive decline in Alzheimer's disease.
EBI GWAS Catalog
Genome-wide meta-analysis of systolic blood pressure in children with sickle cell disease.
EBI GWAS Catalog
Genome-wide search for replicable risk gene regions in alcohol and nicotine co-dependence.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Protein interactions

Protein Gene Interaction Pubs
capsid gag Depletion of the PLEKHG1 expression upregulates HIV-1 CA A92E mutant infectivity in CsA-untreated HeLa cells and downregulates its infectivity in CsA-treated HeLa cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • FLJ31738, KIAA1209

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
enables guanyl-nucleotide exchange factor activity TAS
Traceable Author Statement
more info
 
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
Preferred Names
pleckstrin homology domain-containing family G member 1
Names
pleckstrin homology domain containing, family G (with RhoGef domain) member 1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051299.1 RefSeqGene

    Range
    5023..248803
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001029884.3NP_001025055.1  pleckstrin homology domain-containing family G member 1 isoform c

    See identical proteins and their annotated locations for NP_001025055.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), as well as variants 4 and 5, encodes isoform c.
    Source sequence(s)
    AL035086, AL450339, AL450344
    Consensus CDS
    CCDS34552.1
    UniProtKB/Swiss-Prot
    Q5T1F2, Q9ULL1
    UniProtKB/TrEMBL
    Q5EBL9, Q5JYA6
    Related
    ENSP00000512689.1, ENST00000696526.1
    Conserved Domains (2) summary
    cd13243
    Location:273418
    PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00621
    Location:117291
    RhoGEF; RhoGEF domain
  2. NM_001329798.2NP_001316727.1  pleckstrin homology domain-containing family G member 1 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AL035086, AL450339, AL450344
    UniProtKB/TrEMBL
    Q5EBL9
    Conserved Domains (3) summary
    cd13243
    Location:332477
    PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00169
    Location:381474
    PH; PH domain
    pfam00621
    Location:176351
    RhoGEF; RhoGEF domain
  3. NM_001329799.2NP_001316728.1  pleckstrin homology domain-containing family G member 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL035086, AL450339, AL450344
    UniProtKB/TrEMBL
    Q5EBL9
  4. NM_001329800.2NP_001316729.1  pleckstrin homology domain-containing family G member 1 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variants 3 and 5, encodes isoform c.
    Source sequence(s)
    AL035086, AL450339, AL450344
    Consensus CDS
    CCDS34552.1
    UniProtKB/Swiss-Prot
    Q5T1F2, Q9ULL1
    UniProtKB/TrEMBL
    Q5EBL9, Q5JYA6
    Related
    ENSP00000496254.1, ENST00000644968.1
    Conserved Domains (2) summary
    cd13243
    Location:273418
    PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00621
    Location:117291
    RhoGEF; RhoGEF domain
  5. NM_001329801.2NP_001316730.1  pleckstrin homology domain-containing family G member 1 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variants 3 and 4, encodes isoform c.
    Source sequence(s)
    AL035086, AL450339
    Consensus CDS
    CCDS34552.1
    UniProtKB/Swiss-Prot
    Q5T1F2, Q9ULL1
    UniProtKB/TrEMBL
    Q5EBL9, Q5JYA6
    Related
    ENSP00000351318.2, ENST00000358517.6
    Conserved Domains (2) summary
    cd13243
    Location:273418
    PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00621
    Location:117291
    RhoGEF; RhoGEF domain
  6. NM_001329802.2NP_001316731.1  pleckstrin homology domain-containing family G member 1 isoform d

    Status: VALIDATED

    Source sequence(s)
    AL035086, AL450339
    UniProtKB/TrEMBL
    Q5EBL9
  7. NM_001329803.2NP_001316732.1  pleckstrin homology domain-containing family G member 1 isoform e

    Status: VALIDATED

    Source sequence(s)
    AL035086, AL450339
    UniProtKB/TrEMBL
    Q5EBL9
  8. NM_001329804.2NP_001316733.1  pleckstrin homology domain-containing family G member 1 isoform f

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8), as well as variants 9 and 10, encodes isoform f.
    Source sequence(s)
    AL035086, AL450339, AL450344
  9. NM_001329805.2NP_001316734.1  pleckstrin homology domain-containing family G member 1 isoform f

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9), as well as variants 8 and 10, encodes isoform f.
    Source sequence(s)
    AL035086, AL450339, AL450344
  10. NM_001329806.2NP_001316735.1  pleckstrin homology domain-containing family G member 1 isoform f

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10), as well as variants 8 and 9, encodes isoform f.
    Source sequence(s)
    AL035086, AL450339

RNA

  1. NR_138136.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL450344
    Related
    ENST00000643446.1
  2. NR_138137.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL450344
  3. NR_138138.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL450344
  4. NR_138139.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL450344
  5. NR_138140.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL450344

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    150599885..150843665
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    151800395..152044215
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)