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USP31 ubiquitin specific peptidase 31 [ Homo sapiens (human) ]

Gene ID: 57478, updated on 7-Jun-2020

Summary

Official Symbol
USP31provided by HGNC
Official Full Name
ubiquitin specific peptidase 31provided by HGNC
Primary source
HGNC:HGNC:20060
See related
Ensembl:ENSG00000103404
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in testis (RPKM 7.0), urinary bladder (RPKM 3.7) and 24 other tissues See more
Orthologs

Genomic context

See USP31 in Genome Data Viewer
Location:
16p12.2
Exon count:
19
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (23061407..23149301, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (23072727..23160591, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984851 Neighboring gene heparan sulfate-glucosamine 3-sulfotransferase 2 Neighboring gene uncharacterized LOC112268176 Neighboring gene sodium channel epithelial 1 subunit gamma Neighboring gene sodium channel epithelial 1 subunit beta

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1203

Gene Ontology Provided by GOA

Function Evidence Code Pubs
thiol-dependent ubiquitin-specific protease activity IDA
Inferred from Direct Assay
more info
 
Process Evidence Code Pubs
protein deubiquitination IDA
Inferred from Direct Assay
more info
 
ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
ubiquitin carboxyl-terminal hydrolase 31
Names
deubiquitinating enzyme 31
ubiquitin specific proteinase 31
ubiquitin thioesterase 31
ubiquitin thiolesterase 31
ubiquitin-specific-processing protease 31
NP_065769.3
XP_016878985.1
XP_016878986.1
XP_016878987.1
XP_016878988.1
XP_016878989.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020718.3NP_065769.3  ubiquitin carboxyl-terminal hydrolase 31

    See identical proteins and their annotated locations for NP_065769.3

    Status: VALIDATED

    Source sequence(s)
    AC127459, AJ586135, BM842261
    Consensus CDS
    CCDS10607.1
    UniProtKB/Swiss-Prot
    Q70CQ4
    Related
    ENSP00000219689.7, ENST00000219689.11
    Conserved Domains (3) summary
    cd02674
    Location:596763
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:129335
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam10243
    Location:10131346
    MIP-T3; Microtubule-binding protein MIP-T3

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    23061407..23149301 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017023496.2XP_016878985.1  ubiquitin carboxyl-terminal hydrolase 31 isoform X1

  2. XM_017023497.2XP_016878986.1  ubiquitin carboxyl-terminal hydrolase 31 isoform X2

    Conserved Domains (3) summary
    cd02674
    Location:333500
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:1472
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam10243
    Location:7501083
    MIP-T3; Microtubule-binding protein MIP-T3
  3. XM_017023498.2XP_016878987.1  ubiquitin carboxyl-terminal hydrolase 31 isoform X2

    Conserved Domains (3) summary
    cd02674
    Location:333500
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:1472
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam10243
    Location:7501083
    MIP-T3; Microtubule-binding protein MIP-T3
  4. XM_017023499.2XP_016878988.1  ubiquitin carboxyl-terminal hydrolase 31 isoform X3

  5. XM_017023500.1XP_016878989.1  ubiquitin carboxyl-terminal hydrolase 31 isoform X4

RNA

  1. XR_001751957.1 RNA Sequence

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