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ZNF490 zinc finger protein 490 [ Homo sapiens (human) ]

Gene ID: 57474, updated on 27-Nov-2024

Summary

Official Symbol
ZNF490provided by HGNC
Official Full Name
zinc finger protein 490provided by HGNC
Primary source
HGNC:HGNC:23705
See related
Ensembl:ENSG00000188033 MIM:620118; AllianceGenome:HGNC:23705
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thyroid (RPKM 1.3), spleen (RPKM 1.3) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF490 in Genome Data Viewer
Location:
19p13.2-p13.13
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (12576100..12610813, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (12704509..12735153, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (12686914..12721627, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 88 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:12663347-12663848 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:12663849-12664348 Neighboring gene long intergenic non-protein coding RNA 2926 Neighboring gene phosphoglycerate kinase 1, pseudogene 2 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:12690738-12691937 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14058 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10153 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14059 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14060 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:12724145-12724645 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10154 Neighboring gene vomeronasal 2 receptor 16 pseudogene Neighboring gene zinc finger protein 791 Neighboring gene uncharacterized LOC105372279 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:12750843-12751363 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr19:12754106-12755305 Neighboring gene ribosomal protein L10 pseudogene 16

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA1198

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020714.3NP_065765.1  zinc finger protein 490

    See identical proteins and their annotated locations for NP_065765.1

    Status: VALIDATED

    Source sequence(s)
    AB033024, AC010422
    Consensus CDS
    CCDS12272.1
    UniProtKB/Swiss-Prot
    Q9ULM2
    Related
    ENSP00000311521.6, ENST00000311437.11
    Conserved Domains (3) summary
    COG5048
    Location:192505
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:392412
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:5697
    KRAB; KRAB box

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    12576100..12610813 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    12704509..12735153 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)