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ZNF512B zinc finger protein 512B [ Homo sapiens (human) ]

Gene ID: 57473, updated on 7-Jun-2020

Summary

Official Symbol
ZNF512Bprovided by HGNC
Official Full Name
zinc finger protein 512Bprovided by HGNC
Primary source
HGNC:HGNC:29212
See related
Ensembl:ENSG00000196700 MIM:617886
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GM632
Expression
Ubiquitous expression in brain (RPKM 5.4), thyroid (RPKM 5.3) and 25 other tissues See more
Orthologs

Genomic context

See ZNF512B in Genome Data Viewer
Location:
20q13.33
Exon count:
20
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (63956703..63969930, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (62588057..62601223, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene microRNA 1914 Neighboring gene uridine-cytidine kinase 1 like 1 Neighboring gene microRNA 647 Neighboring gene UCKL1 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 2003 Neighboring gene sterile alpha motif domain containing 10 Neighboring gene pre-mRNA processing factor 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of zinc finger protein 512B (ZNF512B) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1196, MGC149845, MGC149846

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020713.3NP_065764.1  zinc finger protein 512B

    See identical proteins and their annotated locations for NP_065764.1

    Status: VALIDATED

    Source sequence(s)
    AL118506, AL834525, AW453003, BC125128, BC125129
    Consensus CDS
    CCDS13548.1
    UniProtKB/Swiss-Prot
    Q96KM6
    Related
    ENSP00000358904.1, ENST00000369888.6
    Conserved Domains (2) summary
    sd00017
    Location:596617
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl26386
    Location:223448
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    63956703..63969930 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451951.1XP_024307719.1  zinc finger protein 512B isoform X2

    Conserved Domains (3) summary
    sd00017
    Location:596617
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:512541
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl26386
    Location:223448
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  2. XM_024451950.1XP_024307718.1  zinc finger protein 512B isoform X1

    Conserved Domains (2) summary
    sd00017
    Location:610631
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl26386
    Location:237462
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  3. XM_024451952.1XP_024307720.1  zinc finger protein 512B isoform X2

    Conserved Domains (3) summary
    sd00017
    Location:596617
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:512541
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl26386
    Location:223448
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  4. XM_011528930.2XP_011527232.1  zinc finger protein 512B isoform X4

    Conserved Domains (3) summary
    PRK12323
    Location:237462
    PRK12323; DNA polymerase III subunits gamma and tau; Provisional
    sd00017
    Location:610631
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:526555
    ZF_C2H2; C2H2 Zn finger [structural motif]
  5. XM_024451953.1XP_024307721.1  zinc finger protein 512B isoform X3

    Conserved Domains (2) summary
    sd00017
    Location:610631
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl26386
    Location:237462
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  6. XM_024451954.1XP_024307722.1  zinc finger protein 512B isoform X5

    Conserved Domains (1) summary
    sd00017
    Location:266287
    ZF_C2H2; C2H2 Zn finger [structural motif]
  7. XM_024451955.1XP_024307723.1  zinc finger protein 512B isoform X6

    Conserved Domains (1) summary
    sd00017
    Location:265286
    ZF_C2H2; C2H2 Zn finger [structural motif]
  8. XM_011528933.2XP_011527235.1  zinc finger protein 512B isoform X7

    Conserved Domains (2) summary
    PTZ00249
    Location:294430
    PTZ00249; variable surface protein Vir28; Provisional
    PRK14950
    Location:236308
    PRK14950; DNA polymerase III subunits gamma and tau; Provisional
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