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CNOT6 CCR4-NOT transcription complex subunit 6 [ Homo sapiens (human) ]

Gene ID: 57472, updated on 1-Jun-2020

Summary

Official Symbol
CNOT6provided by HGNC
Official Full Name
CCR4-NOT transcription complex subunit 6provided by HGNC
Primary source
HGNC:HGNC:14099
See related
Ensembl:ENSG00000113300 MIM:608951
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CCR4; Ccr4a
Summary
This gene encodes the catalytic component of the CCR4-NOT core transcriptional regulation complex. The encoded protein has a 3'-5' RNase activity and prefers polyadenylated substrates. The CCR4-NOT complex plays a role in many cellular processes, including miRNA-mediated repression, mRNA degradation, and transcriptional regulation. [provided by RefSeq, Dec 2014]
Expression
Ubiquitous expression in testis (RPKM 8.0), urinary bladder (RPKM 6.4) and 25 other tissues See more
Orthologs

Genomic context

See CNOT6 in Genome Data Viewer
Location:
5q35.3
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (180494373..180578358)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (179921412..180005358)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 525, pseudogene Neighboring gene uncharacterized LOC102725231 Neighboring gene proteolipid protein 2 (colonic epithelium-enriched) pseudogene Neighboring gene secretoglobin family 3A member 1 Neighboring gene fms related receptor tyrosine kinase 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1194

Gene Ontology Provided by GOA

Function Evidence Code Pubs
3'-5'-exoribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA binding IEA
Inferred from Electronic Annotation
more info
 
exoribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
poly(A)-specific ribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
poly(A)-specific ribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
poly(A)-specific ribonuclease activity TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
CCR4-NOT complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
CCR4-NOT complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
membrane HDA PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
CCR4-NOT transcription complex subunit 6
Names
carbon catabolite repression 4 protein
carbon catabolite repressor protein 4 homolog
cytoplasmic deadenylase
NP_001357401.1
NP_001357402.1
NP_001357403.1
XP_016865160.1
XP_016865161.1
XP_024301904.1
XP_024301905.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001370472.1NP_001357401.1  CCR4-NOT transcription complex subunit 6 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC034213, AC122714
    Consensus CDS
    CCDS4455.1
    Related
    ENSP00000261951.4, ENST00000261951.9
    Conserved Domains (3) summary
    cd10313
    Location:191540
    Deadenylase_CCR4a; C-terminal deadenylase domain of CCR4a, also known as CCR4-NOT transcription complex subunit 6
    COG4886
    Location:52159
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:3352
    LRR_1; leucine-rich repeat [structural motif]
  2. NM_001370473.1NP_001357402.1  CCR4-NOT transcription complex subunit 6 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC034213, AC122714
    Conserved Domains (3) summary
    cd10313
    Location:186535
    Deadenylase_CCR4a; C-terminal deadenylase domain of CCR4a, also known as CCR4-NOT transcription complex subunit 6
    COG4886
    Location:52158
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:3352
    LRR_1; leucine-rich repeat [structural motif]
  3. NM_001370474.1NP_001357403.1  CCR4-NOT transcription complex subunit 6 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC122714
    Conserved Domains (2) summary
    cd10313
    Location:96445
    Deadenylase_CCR4a; C-terminal deadenylase domain of CCR4a, also known as CCR4-NOT transcription complex subunit 6
    sd00033
    Location:426
    LRR_RI; leucine-rich repeat [structural motif]

RNA

  1. NR_163437.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC034213, AC122714
  2. NR_163438.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC034213, AC122714

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    180494373..180578358
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446137.1XP_024301905.1  CCR4-NOT transcription complex subunit 6 isoform X5

    Conserved Domains (1) summary
    cd10313
    Location:16365
    Deadenylase_CCR4a; C-terminal deadenylase domain of CCR4a, also known as CCR4-NOT transcription complex subunit 6
  2. XM_017009672.1XP_016865161.1  CCR4-NOT transcription complex subunit 6 isoform X4

    Conserved Domains (4) summary
    sd00031
    Location:3352
    LRR_1; leucine-rich repeat [structural motif]
    pfam12799
    Location:5191
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:51109
    LRR_8; Leucine rich repeat
    cl00490
    Location:191420
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
  3. XM_024446136.1XP_024301904.1  CCR4-NOT transcription complex subunit 6 isoform X5

    Conserved Domains (1) summary
    cd10313
    Location:16365
    Deadenylase_CCR4a; C-terminal deadenylase domain of CCR4a, also known as CCR4-NOT transcription complex subunit 6
  4. XM_017009671.2XP_016865160.1  CCR4-NOT transcription complex subunit 6 isoform X3

    Conserved Domains (2) summary
    cd10313
    Location:96445
    Deadenylase_CCR4a; C-terminal deadenylase domain of CCR4a, also known as CCR4-NOT transcription complex subunit 6
    sd00033
    Location:426
    LRR_RI; leucine-rich repeat [structural motif]

RNA

  1. XR_001742164.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001303241.2: Suppressed sequence

    Description
    NM_001303241.2: This RefSeq was removed because currently there is insufficient support for the transcript. Intron1 is not supported by transcript data and likely represented repeat copy number variation.
  2. NM_015455.3: Suppressed sequence

    Description
    NM_015455.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
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