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MYORG myogenesis regulating glycosidase (putative) [ Homo sapiens (human) ]

Gene ID: 57462, updated on 25-Dec-2023

Summary

Official Symbol
MYORGprovided by HGNC
Official Full Name
myogenesis regulating glycosidase (putative)provided by HGNC
Primary source
HGNC:HGNC:19918
See related
Ensembl:ENSG00000164976 MIM:618255; AllianceGenome:HGNC:19918
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IBGC7; NET37; KIAA1161
Summary
Predicted to enable hydrolase activity, hydrolyzing O-glycosyl compounds. Involved in skeletal muscle fiber development. Predicted to be located in endoplasmic reticulum membrane and nuclear membrane. Implicated in basal ganglia calcification. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in duodenum (RPKM 7.6), small intestine (RPKM 7.3) and 18 other tissues See more
Orthologs
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Genomic context

See MYORG in Genome Data Viewer
Location:
9p13.3
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (34366666..34376898, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (34385154..34395421, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (34366664..34376896, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene kinesin family member 24 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:34318623-34319288 Neighboring gene serpin family H member 1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28307 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28308 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:34329280-34329787 Neighboring gene nudix hydrolase 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:34371826-34372326 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:34372327-34372827 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:34375663-34376244 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:34376245-34376825 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19844 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:34380811-34381416 Neighboring gene uncharacterized LOC124902144 Neighboring gene sperm microtubule inner protein 6 Neighboring gene family with sequence similarity 219 member A Neighboring gene uncharacterized LOC124902145

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of insulin-like growth factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in skeletal muscle fiber development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in skeletal muscle fiber development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in skeletal muscle fiber development ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nuclear membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
myogenesis-regulating glycosidase
NP_065753.2
XP_011516268.1
XP_016870419.1
XP_054219293.1
XP_054219294.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020702.5NP_065753.2  myogenesis-regulating glycosidase

    See identical proteins and their annotated locations for NP_065753.2

    Status: VALIDATED

    Source sequence(s)
    AB032987, AI066728, AL356494, AW008982, BC110493, CB988183
    Consensus CDS
    CCDS78391.1
    UniProtKB/Swiss-Prot
    Q5T587, Q5T588, Q6NSJ0, Q9ULQ9
    Related
    ENSP00000297625.8, ENST00000297625.8
    Conserved Domains (2) summary
    cd06592
    Location:314682
    GH31_NET37; glucosidase NET37
    pfam01055
    Location:329707
    Glyco_hydro_31; Glycosyl hydrolases family 31

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    34366666..34376898 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011517966.4XP_011516268.1  myogenesis-regulating glycosidase isoform X1

    See identical proteins and their annotated locations for XP_011516268.1

    UniProtKB/Swiss-Prot
    Q5T587, Q5T588, Q6NSJ0, Q9ULQ9
    Conserved Domains (2) summary
    cd06592
    Location:314682
    GH31_NET37; glucosidase NET37
    pfam01055
    Location:329707
    Glyco_hydro_31; Glycosyl hydrolases family 31
  2. XM_017014930.3XP_016870419.1  myogenesis-regulating glycosidase isoform X1

    UniProtKB/Swiss-Prot
    Q5T587, Q5T588, Q6NSJ0, Q9ULQ9
    Conserved Domains (2) summary
    cd06592
    Location:314682
    GH31_NET37; glucosidase NET37
    pfam01055
    Location:329707
    Glyco_hydro_31; Glycosyl hydrolases family 31

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    34385154..34395421 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054363319.1XP_054219294.1  myogenesis-regulating glycosidase isoform X1

  2. XM_054363318.1XP_054219293.1  myogenesis-regulating glycosidase isoform X1