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PPM1H protein phosphatase, Mg2+/Mn2+ dependent 1H [ Homo sapiens (human) ]

Gene ID: 57460, updated on 9-May-2020

Summary

Official Symbol
PPM1Hprovided by HGNC
Official Full Name
protein phosphatase, Mg2+/Mn2+ dependent 1Hprovided by HGNC
Primary source
HGNC:HGNC:18583
See related
Ensembl:ENSG00000111110 MIM:616016
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
URCC2; ARHCL1; NERPP-2C
Expression
Broad expression in brain (RPKM 7.7), prostate (RPKM 6.7) and 23 other tissues See more
Orthologs

Genomic context

See PPM1H in Genome Data Viewer
Location:
12q14.1-q14.2
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (62643992..62935150, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (63037762..63328665, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1465 Neighboring gene microRNA let-7i Neighboring gene Sharpr-MPRA regulatory region 14116 Neighboring gene ribosomal protein L32 pseudogene 26 Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 44 Neighboring gene uncharacterized LOC105369795 Neighboring gene RNA, U1 small nuclear 83, pseudogene Neighboring gene ribosomal protein L14 pseudogene 1 Neighboring gene chromosome 6 open reading frame 35 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13253, KIAA1157

Gene Ontology Provided by GOA

Function Evidence Code Pubs
[pyruvate dehydrogenase (lipoamide)] phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
magnesium-dependent protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphoprotein phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
positive regulation of pyruvate dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein phosphatase 1H
Names
neurite extension-related protein phosphatase related to PP2C
protein phosphatase 1H (PP2C domain containing)
ras homolog gene family, member C like 1
NP_065751.1
XP_011536880.1
XP_011536881.1
XP_016875165.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020700.2NP_065751.1  protein phosphatase 1H

    See identical proteins and their annotated locations for NP_065751.1

    Status: VALIDATED

    Source sequence(s)
    AB032983, AC048341, AC078814, DA396561
    Consensus CDS
    CCDS44934.1
    UniProtKB/Swiss-Prot
    Q9ULR3
    Related
    ENSP00000228705.5, ENST00000228705.7
    Conserved Domains (1) summary
    cd00143
    Location:143507
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    62643992..62935150 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011538578.2XP_011536880.1  protein phosphatase 1H isoform X1

    See identical proteins and their annotated locations for XP_011536880.1

    Conserved Domains (1) summary
    cd00143
    Location:105469
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
  2. XM_011538579.1XP_011536881.1  protein phosphatase 1H isoform X3

    Conserved Domains (1) summary
    cd00143
    Location:1256
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
  3. XM_017019676.2XP_016875165.1  protein phosphatase 1H isoform X2

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