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TMCC3 transmembrane and coiled-coil domain family 3 [ Homo sapiens (human) ]

Gene ID: 57458, updated on 13-Mar-2020

Summary

Official Symbol
TMCC3provided by HGNC
Official Full Name
transmembrane and coiled-coil domain family 3provided by HGNC
Primary source
HGNC:HGNC:29199
See related
Ensembl:ENSG00000057704 MIM:617459
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in colon (RPKM 11.8), small intestine (RPKM 10.1) and 24 other tissues See more
Orthologs

Genomic context

See TMCC3 in Genome Data Viewer
Location:
12q22
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (94567122..94650557, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (94960900..95044324, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene SUCLG2 pseudogene 2 Neighboring gene microRNA 5700 Neighboring gene microRNA 7844 Neighboring gene LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated pseudogene 2 Neighboring gene translation initiation factor IF-2-like Neighboring gene keratin 19 pseudogene 2 Neighboring gene microRNA 492 Neighboring gene uncharacterized LOC105369915

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1145

Gene Ontology Provided by GOA

Function Evidence Code Pubs
14-3-3 protein binding IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transmembrane and coiled-coil domain protein 3
Names
transmembrane and coiled-coil domains 3
transmembrane and coiled-coil domains protein 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301036.2NP_001287965.1  transmembrane and coiled-coil domain protein 3 isoform 2

    See identical proteins and their annotated locations for NP_001287965.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AB032971, AC026672, AI361720
    Consensus CDS
    CCDS73506.1
    UniProtKB/Swiss-Prot
    Q9ULS5
    UniProtKB/TrEMBL
    G3V207
    Related
    ENSP00000449888.1, ENST00000551457.1
    Conserved Domains (1) summary
    pfam10267
    Location:38432
    Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein
  2. NM_020698.4NP_065749.3  transmembrane and coiled-coil domain protein 3 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC026672
    Consensus CDS
    CCDS31877.1
    Related
    ENSP00000261226.4, ENST00000261226.9
    Conserved Domains (1) summary
    pfam10267
    Location:69463
    Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    94567122..94650557 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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