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UGT2A2 UDP glucuronosyltransferase family 2 member A2 [ Homo sapiens (human) ]

Gene ID: 574537, updated on 9-Dec-2022

Summary

Official Symbol
UGT2A2provided by HGNC
Official Full Name
UDP glucuronosyltransferase family 2 member A2provided by HGNC
Primary source
HGNC:HGNC:28183
See related
Ensembl:ENSG00000271271 MIM:619809; AllianceGenome:HGNC:28183
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UDPGT 2A2
Summary
The protein encoded by this gene belongs to the UDP-glycosyltransferase family. Members of this protein family play a role in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. The encoded enzyme is expressed in the olfactory neuroepithelium, which lines the posterior nasal cavity and is exposed to a wide range of odorants and airborne toxic compounds. Hence, this protein has been suggested to be involved in clearing lipophilic odorant molecules from the sensory epithelium. This gene shares exon structure with the UDP glucuronosyltransferase 2A1 family member, which encodes N-terminally distinct isoforms. Polymorphisms in this gene may be associated with the loss of taste and smell that is reported by some individuals during SARS-CoV-2 infection. [provided by RefSeq, Jan 2022]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is relevant for disease process.
Expression
Biased expression in kidney (RPKM 3.0), liver (RPKM 2.9) and 1 other tissue See more
Orthologs
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Genomic context

See UGT2A2 in Genome Data Viewer
Location:
4q13.3
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (69588417..69639642, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (72923224..72974440, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (70454135..70505360, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene UDP glucuronosyltransferase family 2 member B4 Neighboring gene UDP glucuronosyltransferase family 2 member A3 pseudogene 7 Neighboring gene UDP glucuronosyltransferase family 2 member B7 pseudogene Neighboring gene UDP glucuronosyltransferase family 2 member A1 complex locus Neighboring gene sulfotransferase family 1B member 1 Neighboring gene sulfotransferase family 1D member 1, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables glucuronosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables glucuronosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in bile acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular glucuronidation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
UDP-glucuronosyltransferase 2A2
Names
UDP glucuronosyltransferase 2 family, polypeptide A2
NP_001099147.2
NP_001288162.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105677.2NP_001099147.2  UDP-glucuronosyltransferase 2A2 isoform UGT2A2_i1

    See identical proteins and their annotated locations for NP_001099147.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (UGT2A2_i1).
    Source sequence(s)
    AC093829, FJ664272
    Consensus CDS
    CCDS56331.1
    UniProtKB/Swiss-Prot
    Q9Y4X1
    Related
    ENSP00000475028.2, ENST00000604629.6
    Conserved Domains (1) summary
    pfam00201
    Location:30524
    UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase
  2. NM_001301233.1NP_001288162.1  UDP-glucuronosyltransferase 2A2 isoform UGT2A2_i2

    See identical proteins and their annotated locations for NP_001288162.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2, also known as UGT2A2deltaexon3) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (UGT2A2_i2) that is shorter than isoform UGT2A2_i1.
    Source sequence(s)
    AC093829, FJ664273
    Consensus CDS
    CCDS77924.1
    UniProtKB/Swiss-Prot
    Q9Y4X1
    Related
    ENSP00000474383.2, ENST00000604021.1
    Conserved Domains (2) summary
    PHA03392
    Location:295469
    egt; ecdysteroid UDP-glucosyltransferase; Provisional
    pfam00201
    Location:30480
    UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    69588417..69639642 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    72923224..72974440 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)