Format

Send to:

Choose Destination

BIRC6 baculoviral IAP repeat containing 6 [ Homo sapiens (human) ]

Gene ID: 57448, updated on 9-Feb-2020

Summary

Official Symbol
BIRC6provided by HGNC
Official Full Name
baculoviral IAP repeat containing 6provided by HGNC
Primary source
HGNC:HGNC:13516
See related
Ensembl:ENSG00000115760 MIM:605638
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BRUCE; APOLLON
Summary
This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 6.5), ovary (RPKM 6.3) and 25 other tissues See more
Orthologs

Genomic context

See BIRC6 in Genome Data Viewer
Location:
2p22.3
Exon count:
78
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (32356907..32618899)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (32581735..32843966)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene NLR family CARD domain containing 4 Neighboring gene Yip1 domain family member 4 Neighboring gene BIRC6 antisense RNA 2 Neighboring gene microRNA 558 Neighboring gene microRNA 4765 Neighboring gene tetratricopeptide repeat domain 27 Neighboring gene long intergenic non-protein coding RNA 486 Neighboring gene Sharpr-MPRA regulatory region 6729

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13726, FLJ13786, KIAA1289, AL133243.1

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cysteine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cysteine-type endopeptidase inhibitor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
labyrinthine layer development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
negative regulation of endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of extrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation TAS
Traceable Author Statement
more info
PubMed 
protein ubiquitination TAS
Traceable Author Statement
more info
PubMed 
regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
spongiotrophoblast layer development IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Flemming body IEA
Inferred from Electronic Annotation
more info
 
endosome IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
microtubule organizing center IDA
Inferred from Direct Assay
more info
PubMed 
midbody IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spindle pole IDA
Inferred from Direct Assay
more info
PubMed 
trans-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
baculoviral IAP repeat-containing protein 6
Names
BIR repeat-containing ubiquitin-conjugating enzyme
RING-type E3 ubiquitin transferase BIRC6
ubiquitin-conjugating BIR-domain enzyme apollon
NP_057336.3
XP_005264506.2
XP_005264507.2
XP_005264508.2
XP_005264509.2
XP_005264510.2
XP_005264511.2
XP_005264512.2
XP_006712117.1
XP_006712118.1
XP_006712119.1
XP_011531305.1
XP_011531307.1
XP_016860045.1
XP_016860046.1
XP_016860047.1
XP_016860048.1
XP_016860049.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001378125.1NP_001365054.1  baculoviral IAP repeat-containing protein 6 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL133243, AL133245, AL133246, KF456651, KF456657
  2. NM_016252.3NP_057336.3  baculoviral IAP repeat-containing protein 6 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AA315620, AB033115, AF265555, AL133245, AL133246, BM674459
    Consensus CDS
    CCDS33175.2
    UniProtKB/Swiss-Prot
    Q9NR09
    Related
    ENSP00000393596.2, ENST00000421745.6
    Conserved Domains (3) summary
    cd00022
    Location:287360
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd00195
    Location:45974735
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    pfam12356
    Location:34663618
    DUF3643; Protein of unknown function (DUF3643)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    32356907..32618899
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005264454.5XP_005264511.2  baculoviral IAP repeat-containing protein 6 isoform X11

    Conserved Domains (3) summary
    cd00022
    Location:287360
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd00195
    Location:45874725
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    pfam12356
    Location:34933645
    DUF3643; Protein of unknown function (DUF3643)
  2. XM_005264449.4XP_005264506.2  baculoviral IAP repeat-containing protein 6 isoform X1

    Conserved Domains (3) summary
    cd00022
    Location:287360
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd00195
    Location:46244762
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    pfam12356
    Location:34933645
    DUF3643; Protein of unknown function (DUF3643)
  3. XM_006712055.3XP_006712118.1  baculoviral IAP repeat-containing protein 6 isoform X6

    Conserved Domains (3) summary
    cd00022
    Location:287360
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd00195
    Location:46044742
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    pfam12356
    Location:34733625
    DUF3643; Protein of unknown function (DUF3643)
  4. XM_005264451.4XP_005264508.2  baculoviral IAP repeat-containing protein 6 isoform X4

    Conserved Domains (3) summary
    cd00022
    Location:287360
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd00195
    Location:46154753
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    pfam12356
    Location:34843636
    DUF3643; Protein of unknown function (DUF3643)
  5. XM_006712054.3XP_006712117.1  baculoviral IAP repeat-containing protein 6 isoform X3

    Conserved Domains (3) summary
    cd00022
    Location:287360
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd00195
    Location:46184756
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    pfam12356
    Location:34873639
    DUF3643; Protein of unknown function (DUF3643)
  6. XM_017004556.1XP_016860045.1  baculoviral IAP repeat-containing protein 6 isoform X8

  7. XM_006712056.3XP_006712119.1  baculoviral IAP repeat-containing protein 6 isoform X9

    Conserved Domains (3) summary
    cd00022
    Location:287360
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd00195
    Location:45914729
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    pfam12356
    Location:34603612
    DUF3643; Protein of unknown function (DUF3643)
  8. XM_005264450.4XP_005264507.2  baculoviral IAP repeat-containing protein 6 isoform X2

    Conserved Domains (3) summary
    cd00022
    Location:287360
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd00195
    Location:46204758
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    pfam12356
    Location:34893641
    DUF3643; Protein of unknown function (DUF3643)
  9. XM_017004557.1XP_016860046.1  baculoviral IAP repeat-containing protein 6 isoform X10

  10. XM_017004558.1XP_016860047.1  baculoviral IAP repeat-containing protein 6 isoform X13

  11. XM_005264455.4XP_005264512.2  baculoviral IAP repeat-containing protein 6 isoform X12

    Conserved Domains (3) summary
    cd00022
    Location:287360
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd00195
    Location:45804718
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    pfam12356
    Location:34493601
    DUF3643; Protein of unknown function (DUF3643)
  12. XM_017004559.1XP_016860048.1  baculoviral IAP repeat-containing protein 6 isoform X15

    Conserved Domains (3) summary
    cd00022
    Location:287360
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    pfam12356
    Location:34933645
    DUF3643; Protein of unknown function (DUF3643)
    cl00154
    Location:46244694
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  13. XM_011533005.2XP_011531307.1  baculoviral IAP repeat-containing protein 6 isoform X16

    Related
    ENSP00000498175.1, ENST00000648282.1
    Conserved Domains (2) summary
    cd00022
    Location:287360
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    pfam12356
    Location:34933645
    DUF3643; Protein of unknown function (DUF3643)
  14. XM_017004560.1XP_016860049.1  baculoviral IAP repeat-containing protein 6 isoform X17

  15. XM_005264452.4XP_005264509.2  baculoviral IAP repeat-containing protein 6 isoform X5

    Conserved Domains (3) summary
    cd00022
    Location:287360
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd00195
    Location:46104748
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    pfam12356
    Location:34793631
    DUF3643; Protein of unknown function (DUF3643)
  16. XM_005264453.4XP_005264510.2  baculoviral IAP repeat-containing protein 6 isoform X7

    Conserved Domains (3) summary
    cd00022
    Location:287360
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd00195
    Location:46014739
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    pfam12356
    Location:34703622
    DUF3643; Protein of unknown function (DUF3643)
  17. XM_011533003.2XP_011531305.1  baculoviral IAP repeat-containing protein 6 isoform X14

    Conserved Domains (3) summary
    cd00022
    Location:182255
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd00195
    Location:45194657
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    pfam12356
    Location:33883540
    DUF3643; Protein of unknown function (DUF3643)

RNA

  1. XR_244950.4 RNA Sequence

  2. XR_001738858.2 RNA Sequence

Support Center