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BIRC6 baculoviral IAP repeat containing 6 [ Homo sapiens (human) ]

Gene ID: 57448, updated on 19-Aug-2025
Official Symbol
BIRC6provided by HGNC
Official Full Name
baculoviral IAP repeat containing 6provided by HGNC
Primary source
HGNC:HGNC:13516
See related
Ensembl:ENSG00000115760 MIM:605638; AllianceGenome:HGNC:13516
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BRUCE; APOLLON
Summary
This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 6.5), ovary (RPKM 6.3) and 25 other tissues See more
Orthologs
mouse all
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See BIRC6 in Genome Data Viewer
Location:
2p22.3
Exon count:
75
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (32357023..32618878)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (32405536..32667526)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (32582091..32843945)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:32502088-32502833 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11340 Neighboring gene NLR family CARD domain containing 4 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:32518022-32518694 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:32521211-32521404 Neighboring gene Yip1 domain family member 4 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:32581762-32582274 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11342 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:32582789-32583301 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:32586084-32586282 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:32662063-32662288 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:32672333-32672910 Neighboring gene microRNA 558 Neighboring gene BIRC6 antisense RNA 2 Neighboring gene uncharacterized LOC124905985 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:32852317-32852978 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:32852979-32853638 Neighboring gene microRNA 4765 Neighboring gene tetratricopeptide repeat domain 27

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Suppressive Effect of Constructed shRNAs against Apollon Induces Apoptosis and Growth Inhibition in the HeLa Cell Line. Milani S, et al. Iran Biomed J, 2016 Jul. PMID 26748613, Free PMC Article
  2. BIRC6 modifies risk of invasive bacterial infection in Kenyan children. Gilchrist JJ, et al. Elife, 2022 Jul 22. PMID 35866869, Free PMC Article
  3. [Knock-down of apollon gene by antisense oligodeoxynucleotide inhibits the proliferation of Lovo cells and enhances chemo-sensitivity]. He JH, et al. Yao Xue Xue Bao, 2011 Feb. PMID 21542283
  4. Comparative proteomics of colon cancer stem cells and differentiated tumor cells identifies BIRC6 as a potential therapeutic target. Van Houdt WJ, et al. Mol Cell Proteomics, 2011 Dec. PMID 21788403, Free PMC Article
  5. [Small interfering RNA targeting Apollon enhances the chemosensitivity of hepatocellular carcinoma cells in vitro]. Chen JF, et al. Nan Fang Yi Ke Da Xue Xue Bao, 2011 Oct. PMID 22027771

See all (145) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CircBIRC6 affects prostate cancer progression by regulating miR-574-5p and DNAJB1.
    Title: CircBIRC6 affects prostate cancer progression by regulating miR-574-5p and DNAJB1.
  2. CircBIRC6 facilitates the malignant progression via miR-488/GRIN2D-mediated CAV1-autophagy signal axis in gastric cancer.
    Title: CircBIRC6 facilitates the malignant progression via miR-488/GRIN2D-mediated CAV1-autophagy signal axis in gastric cancer.
  3. Structural basis for regulation of apoptosis and autophagy by the BIRC6/SMAC complex.
    Title: Structural basis for regulation of apoptosis and autophagy by the BIRC6/SMAC complex.
  4. Structures of BIRC6-client complexes provide a mechanism of SMAC-mediated release of caspases.
    Title: Structures of BIRC6-client complexes provide a mechanism of SMAC-mediated release of caspases.
  5. Structural basis for SMAC-mediated antagonism of caspase inhibition by the giant ubiquitin ligase BIRC6.
    Title: Structural basis for SMAC-mediated antagonism of caspase inhibition by the giant ubiquitin ligase BIRC6.
  6. Exploring the Role of the Inhibitor of Apoptosis BIRC6 in Breast Cancer: A Database Analysis.
    Title: Exploring the Role of the Inhibitor of Apoptosis BIRC6 in Breast Cancer: A Database Analysis.
  7. Oral Squamous Cell Carcinoma: The Role of BIRC6 Serum Level.
    Title: Oral Squamous Cell Carcinoma: The Role of BIRC6 Serum Level.
  8. BIRC6 modifies risk of invasive bacterial infection in Kenyan children.
    Title: BIRC6 modifies risk of invasive bacterial infection in Kenyan children.
  9. Silencing circBIRC6 inhibits the proliferation, invasion, migration and epithelialmesenchymal transition of bladder cancer cells by targeting the miR4953p/XBP1 signaling axis.
    Title: Silencing circ‑BIRC6 inhibits the proliferation, invasion, migration and epithelial‑mesenchymal transition of bladder cancer cells by targeting the miR‑495‑3p/XBP1 signaling axis.
  10. BIRC6 Is Associated with Vulnerability of Carotid Atherosclerotic Plaque.
    Title: BIRC6 Is Associated with Vulnerability of Carotid Atherosclerotic Plaque.
Submit: New GeneRIF Correction See all GeneRIFs (47)

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ13726, FLJ13786, KIAA1289, AL133243.1

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cysteine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type endopeptidase inhibitor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin conjugating enzyme activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within labyrinthine layer development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of apoptotic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of extrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in placenta development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell population proliferation TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of cytokinesis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Flemming body IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule organizing center IDA
Inferred from Direct Assay
more info
 PubMed 
located_in midbody IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle pole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle pole IEA
Inferred from Electronic Annotation
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6
Names
BIR repeat-containing ubiquitin-conjugating enzyme
RING-type E3 ubiquitin transferase BIRC6
baculoviral IAP repeat-containing protein 6
ubiquitin-conjugating BIR-domain enzyme apollon
NP_001365054.1
NP_057336.3
XP_005264507.2
XP_005264508.2
XP_005264509.2
XP_005264510.2
XP_005264512.2
XP_006712117.1
XP_006712118.1
XP_006712119.1
XP_011531305.1
XP_016860045.1
XP_016860046.1
XP_016860047.1
XP_047301114.1
XP_047301115.1
XP_047301116.1
XP_047301117.1
XP_047301118.1
XP_047301119.1
XP_047301120.1
XP_047301121.1
XP_047301122.1
XP_047301123.1
XP_047301124.1
XP_047301125.1
XP_047301126.1
XP_047301127.1
XP_047301128.1
XP_047301129.1
XP_047301130.1
XP_047301131.1
XP_047301132.1
XP_047301133.1
XP_047301134.1
XP_047301135.1
XP_047301136.1
XP_047301137.1
XP_047301138.1
XP_047301139.1
XP_047301140.1
XP_047301141.1
XP_047301142.1
XP_047301143.1
XP_047301144.1
XP_047301145.1
XP_047301146.1
XP_047301147.1
XP_047301148.1
XP_047301149.1
XP_054199104.1
XP_054199105.1
XP_054199106.1
XP_054199107.1
XP_054199108.1
XP_054199109.1
XP_054199110.1
XP_054199111.1
XP_054199112.1
XP_054199113.1
XP_054199114.1
XP_054199115.1
XP_054199116.1
XP_054199117.1
XP_054199118.1
XP_054199119.1
XP_054199120.1
XP_054199121.1
XP_054199122.1
XP_054199123.1
XP_054199124.1
XP_054199125.1
XP_054199126.1
XP_054199127.1
XP_054199128.1
XP_054199129.1
XP_054199130.1
XP_054199131.1
XP_054199132.1
XP_054199133.1
XP_054199134.1
XP_054199135.1
XP_054199136.1
XP_054199137.1
XP_054199138.1
XP_054199139.1
XP_054199140.1
XP_054199141.1
XP_054199142.1
XP_054199143.1
XP_054199144.1
XP_054199145.1
XP_054199146.1
XP_054199147.1
XP_054199148.1
XP_054199149.1
XP_054199150.1
XP_054199151.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001378125.1 → NP_001365054.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL133243, AL133245, AL133246, KF456651, KF456657
    Conserved Domains (3) summary
    cd00022
    Location:259 → 332
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd00195
    Location:4596 → 4734
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    pfam12356
    Location:3462 → 3617
    BIRC6; Baculoviral IAP repeat-containing protein 6

  2. NM_016252.4 → NP_057336.3  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL133243, AL133245, AL133246, KF456651, KF456657
    Consensus CDS
    CCDS33175.2
    UniProtKB/Swiss-Prot
    Q9NR09, Q9ULD1
    Related
    ENSP00000393596.2, ENST00000421745.7
    Conserved Domains (3) summary
    cd00022
    Location:287 → 360
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd00195
    Location:4597 → 4735
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    pfam12356
    Location:3466 → 3618
    DUF3643; Protein of unknown function (DUF3643)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    32357023..32618878
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006712055.4 → XP_006712118.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X11

    Conserved Domains (3) summary
    cd00022
    Location:287 → 360
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd00195
    Location:4604 → 4742
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    pfam12356
    Location:3473 → 3625
    DUF3643; Protein of unknown function (DUF3643)

  2. XM_005264451.5 → XP_005264508.2  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X3

    Conserved Domains (3) summary
    cd00022
    Location:287 → 360
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd00195
    Location:4615 → 4753
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    pfam12356
    Location:3484 → 3636
    DUF3643; Protein of unknown function (DUF3643)

  3. XM_047445167.1 → XP_047301123.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X17

  4. XM_006712054.4 → XP_006712117.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X2

    Conserved Domains (3) summary
    cd00022
    Location:287 → 360
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd00195
    Location:4618 → 4756
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    pfam12356
    Location:3487 → 3639
    DUF3643; Protein of unknown function (DUF3643)

  5. XM_017004556.2 → XP_016860045.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X15

  6. XM_047445160.1 → XP_047301116.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X7

  7. XM_006712056.4 → XP_006712119.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X18

    Conserved Domains (3) summary
    cd00022
    Location:287 → 360
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd00195
    Location:4591 → 4729
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    pfam12356
    Location:3460 → 3612
    DUF3643; Protein of unknown function (DUF3643)

  8. XM_047445170.1 → XP_047301126.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X22

  9. XM_047445174.1 → XP_047301130.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X28

  10. XM_005264450.5 → XP_005264507.2  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X1

    Conserved Domains (3) summary
    cd00022
    Location:287 → 360
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd00195
    Location:4620 → 4758
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    pfam12356
    Location:3489 → 3641
    DUF3643; Protein of unknown function (DUF3643)

  11. XM_047445165.1 → XP_047301121.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X14

  12. XM_047445159.1 → XP_047301115.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X5

  13. XM_047445158.1 → XP_047301114.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X4

  14. XM_047445162.1 → XP_047301118.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X9

  15. XM_017004557.2 → XP_016860046.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X20

  16. XM_047445172.1 → XP_047301128.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X25

  17. XM_047445171.1 → XP_047301127.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X23

  18. XM_047445177.1 → XP_047301133.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X31

  19. XM_005264452.5 → XP_005264509.2  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X6

    Conserved Domains (3) summary
    cd00022
    Location:287 → 360
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd00195
    Location:4610 → 4748
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    pfam12356
    Location:3479 → 3631
    DUF3643; Protein of unknown function (DUF3643)

  20. XM_005264453.5 → XP_005264510.2  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X12

    Conserved Domains (3) summary
    cd00022
    Location:287 → 360
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd00195
    Location:4601 → 4739
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    pfam12356
    Location:3470 → 3622
    DUF3643; Protein of unknown function (DUF3643)

  21. XM_047445163.1 → XP_047301119.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X10

  22. XM_047445166.1 → XP_047301122.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X16

  23. XM_017004558.2 → XP_016860047.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X26

    UniProtKB/TrEMBL
    A0A8V8TR92
    Related
    ENSP00000515026.1, ENST00000700519.1

  24. XM_047445180.1 → XP_047301136.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X34

  25. XM_047445184.1 → XP_047301140.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X38

  26. XM_047445161.1 → XP_047301117.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X8

  27. XM_047445169.1 → XP_047301125.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X21

  28. XM_047445164.1 → XP_047301120.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X13

  29. XM_047445168.1 → XP_047301124.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X19

  30. XM_047445176.1 → XP_047301132.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X30

  31. XM_047445183.1 → XP_047301139.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X37

  32. XM_047445182.1 → XP_047301138.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X36

  33. XM_005264455.5 → XP_005264512.2  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X24

    UniProtKB/TrEMBL
    A0A8V8TQB4
    Related
    ENSP00000515025.1, ENST00000700518.1
    Conserved Domains (3) summary
    cd00022
    Location:287 → 360
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd00195
    Location:4580 → 4718
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    pfam12356
    Location:3449 → 3601
    DUF3643; Protein of unknown function (DUF3643)

  34. XM_047445178.1 → XP_047301134.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X32

  35. XM_047445175.1 → XP_047301131.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X29

  36. XM_047445186.1 → XP_047301142.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X40

  37. XM_047445189.1 → XP_047301145.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X43

  38. XM_047445188.1 → XP_047301144.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X42

  39. XM_047445173.1 → XP_047301129.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X27

  40. XM_047445181.1 → XP_047301137.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X35

  41. XM_047445179.1 → XP_047301135.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X33

  42. XM_047445185.1 → XP_047301141.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X39

  43. XM_047445187.1 → XP_047301143.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X41

  44. XM_047445191.1 → XP_047301147.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X45

  45. XM_047445190.1 → XP_047301146.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X44

  46. XM_011533003.3 → XP_011531305.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X46

    Conserved Domains (3) summary
    cd00022
    Location:182 → 255
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd00195
    Location:4519 → 4657
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    pfam12356
    Location:3388 → 3540
    DUF3643; Protein of unknown function (DUF3643)

  47. XM_047445193.1 → XP_047301149.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X48

  48. XM_047445192.1 → XP_047301148.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X47

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    32405536..32667526
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054343139.1 → XP_054199114.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X11

  2. XM_054343131.1 → XP_054199106.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X3

  3. XM_054343145.1 → XP_054199120.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X17

  4. XM_054343130.1 → XP_054199105.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X2

  5. XM_054343143.1 → XP_054199118.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X15

  6. XM_054343135.1 → XP_054199110.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X7

  7. XM_054343146.1 → XP_054199121.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X18

  8. XM_054343150.1 → XP_054199125.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X22

  9. XM_054343156.1 → XP_054199131.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X28

  10. XM_054343129.1 → XP_054199104.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X1

  11. XM_054343142.1 → XP_054199117.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X14

  12. XM_054343133.1 → XP_054199108.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X5

  13. XM_054343132.1 → XP_054199107.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X4

  14. XM_054343137.1 → XP_054199112.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X9

  15. XM_054343148.1 → XP_054199123.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X20

  16. XM_054343153.1 → XP_054199128.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X25

  17. XM_054343151.1 → XP_054199126.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X23

  18. XM_054343159.1 → XP_054199134.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X31

  19. XM_054343134.1 → XP_054199109.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X6

  20. XM_054343140.1 → XP_054199115.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X12

  21. XM_054343138.1 → XP_054199113.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X10

  22. XM_054343144.1 → XP_054199119.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X16

  23. XM_054343154.1 → XP_054199129.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X26

    UniProtKB/TrEMBL
    A0A8V8TR92

  24. XM_054343162.1 → XP_054199137.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X34

  25. XM_054343166.1 → XP_054199141.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X38

  26. XM_054343136.1 → XP_054199111.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X8

  27. XM_054343149.1 → XP_054199124.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X21

  28. XM_054343141.1 → XP_054199116.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X13

  29. XM_054343147.1 → XP_054199122.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X19

  30. XM_054343158.1 → XP_054199133.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X30

  31. XM_054343165.1 → XP_054199140.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X37

  32. XM_054343164.1 → XP_054199139.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X36

  33. XM_054343152.1 → XP_054199127.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X24

    UniProtKB/TrEMBL
    A0A8V8TQB4

  34. XM_054343160.1 → XP_054199135.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X32

  35. XM_054343157.1 → XP_054199132.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X29

  36. XM_054343168.1 → XP_054199143.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X40

  37. XM_054343171.1 → XP_054199146.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X43

  38. XM_054343170.1 → XP_054199145.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X42

  39. XM_054343155.1 → XP_054199130.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X27

  40. XM_054343163.1 → XP_054199138.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X35

  41. XM_054343161.1 → XP_054199136.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X33

  42. XM_054343167.1 → XP_054199142.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X39

  43. XM_054343169.1 → XP_054199144.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X41

  44. XM_054343173.1 → XP_054199148.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X45

  45. XM_054343172.1 → XP_054199147.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X44

  46. XM_054343174.1 → XP_054199149.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X46

  47. XM_054343176.1 → XP_054199151.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X48

  48. XM_054343175.1 → XP_054199150.1  dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform X47

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NR09.3 GenPept UniProtKB/Swiss-Prot:Q9NR09

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