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NDRG3 NDRG family member 3 [ Homo sapiens (human) ]

Gene ID: 57446, updated on 1-Jun-2020

Summary

Official Symbol
NDRG3provided by HGNC
Official Full Name
NDRG family member 3provided by HGNC
Primary source
HGNC:HGNC:14462
See related
Ensembl:ENSG00000101079 MIM:605273
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in brain (RPKM 38.0), prostate (RPKM 20.1) and 23 other tissues See more
Orthologs

Genomic context

See NDRG3 in Genome Data Viewer
Location:
20q11.23
Exon count:
20
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (36651766..36746127, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (35280169..35374541, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene TGIF2-RAB5IF readthrough Neighboring gene RAB5 interacting factor Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene 2 Neighboring gene Src like adaptor 2 Neighboring gene DSN1 component of MIS12 kinetochore complex Neighboring gene suppressor of glucose, autophagy associated 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of NDRG family member 3 (NDRG3) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13556

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of cell growth NAS
Non-traceable Author Statement
more info
PubMed 
signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spermatogenesis NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 

General protein information

Preferred Names
protein NDRG3
Names
N-myc downstream-regulated gene 3 protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022477.4NP_071922.2  protein NDRG3 isoform b

    See identical proteins and their annotated locations for NP_071922.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1, resulting in an isoform (b) that is shorter compared to isoform a.
    Source sequence(s)
    AA903471, AF308609, AK023618, AL132768, BC136489
    Consensus CDS
    CCDS13284.1
    UniProtKB/Swiss-Prot
    Q9UGV2
    Related
    ENSP00000352703.2, ENST00000359675.6
    Conserved Domains (1) summary
    pfam03096
    Location:20305
    Ndr; Ndr family
  2. NM_032013.4NP_114402.1  protein NDRG3 isoform a

    See identical proteins and their annotated locations for NP_114402.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AA903471, AB044943, AF308609, AL132768
    Consensus CDS
    CCDS13285.1
    UniProtKB/Swiss-Prot
    Q9UGV2
    Related
    ENSP00000345292.1, ENST00000349004.6
    Conserved Domains (1) summary
    pfam03096
    Location:32317
    Ndr; Ndr family

RNA

  1. NR_038370.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA903471, AF308609, AK295420, AL132768, BC136489

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    36651766..36746127 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528928.3XP_011527230.1  protein NDRG3 isoform X8

    Related
    ENSP00000362878.3, ENST00000373773.7
    Conserved Domains (2) summary
    COG0596
    Location:19220
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    cl21494
    Location:6225
    Abhydrolase; alpha/beta hydrolases
  2. XM_011528927.3XP_011527229.1  protein NDRG3 isoform X5

    See identical proteins and their annotated locations for XP_011527229.1

    Conserved Domains (2) summary
    COG0596
    Location:26300
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    pfam03096
    Location:20305
    Ndr; Ndr family
  3. XM_006723837.4XP_006723900.1  protein NDRG3 isoform X3

    See identical proteins and their annotated locations for XP_006723900.1

    UniProtKB/TrEMBL
    Q5TH30
    Related
    ENSP00000362909.2, ENST00000373803.6
    Conserved Domains (1) summary
    pfam03096
    Location:32317
    Ndr; Ndr family
  4. XM_017027978.2XP_016883467.1  protein NDRG3 isoform X3

    UniProtKB/TrEMBL
    Q5TH30
    Conserved Domains (1) summary
    pfam03096
    Location:32317
    Ndr; Ndr family
  5. XM_006723838.4XP_006723901.1  protein NDRG3 isoform X4

    Conserved Domains (2) summary
    COG0596
    Location:29303
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    pfam03096
    Location:23308
    Ndr; Ndr family
  6. XM_011528925.3XP_011527227.1  protein NDRG3 isoform X1

    Conserved Domains (2) summary
    COG0596
    Location:8282
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    pfam03096
    Location:2287
    Ndr; Ndr family
  7. XM_017027979.1XP_016883468.1  protein NDRG3 isoform X6

    UniProtKB/Swiss-Prot
    Q9UGV2
    Conserved Domains (1) summary
    pfam03096
    Location:32317
    Ndr; Ndr family
  8. XM_017027980.2XP_016883469.1  protein NDRG3 isoform X7

  9. XM_011528926.2XP_011527228.1  protein NDRG3 isoform X2

    Conserved Domains (2) summary
    COG0596
    Location:8282
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    pfam03096
    Location:2287
    Ndr; Ndr family
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