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Kcne3 potassium voltage-gated channel, Isk-related subfamily, gene 3 [ Mus musculus (house mouse) ]

Gene ID: 57442, updated on 12-May-2024

Summary

Official Symbol
Kcne3provided by MGI
Official Full Name
potassium voltage-gated channel, Isk-related subfamily, gene 3provided by MGI
Primary source
MGI:MGI:1891124
See related
Ensembl:ENSMUSG00000035165 AllianceGenome:MGI:1891124
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MiRP2; 2210017H05Rik
Summary
Predicted to enable potassium channel activity; potassium channel regulator activity; and transmembrane transporter binding activity. Predicted to contribute to delayed rectifier potassium channel activity and voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization. Involved in cellular chloride ion homeostasis; potassium ion transmembrane transport; and sodium ion transport. Is active in basolateral part of cell. Is expressed in several structures, including branchial arch; ear; forelimb bud; gut; and heart. Human ortholog(s) of this gene implicated in Brugada syndrome 6 and hypokalemic periodic paralysis. Orthologous to human KCNE3 (potassium voltage-gated channel subfamily E regulatory subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon adult (RPKM 22.2), testis adult (RPKM 22.1) and 7 other tissues See more
Orthologs
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Genomic context

See Kcne3 in Genome Data Viewer
Location:
7 E2; 7 54.33 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (99825714..99834076)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (100176507..100184869)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 51452 Neighboring gene STARR-positive B cell enhancer ABC_E11740 Neighboring gene lipoyl(octanoyl) transferase 2 (putative) Neighboring gene predicted gene, 39057 Neighboring gene predicted gene, 34821 Neighboring gene predicted gene, 51453 Neighboring gene predicted gene, 45994 Neighboring gene cyclin B1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (5)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to delayed rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables potassium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables potassium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables potassium channel regulator activity ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane transporter binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
 
enables voltage-gated potassium channel activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in intracellular chloride ion homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in intracellular chloride ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in membrane repolarization during action potential IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of delayed rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of delayed rectifier potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of membrane repolarization during ventricular cardiac muscle cell action potential ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of potassium ion export across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of voltage-gated potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
involved_in potassium ion export across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in potassium ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in potassium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within potassium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in potassium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of heart rate by cardiac conduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of heart rate by cardiac conduction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of potassium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of ventricular cardiac muscle cell membrane repolarization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in sodium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in sodium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ventricular cardiac muscle cell action potential IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in basolateral part of cell IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body membrane ISO
Inferred from Sequence Orthology
more info
 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in vesicle ISO
Inferred from Sequence Orthology
more info
 
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
 
part_of voltage-gated potassium channel complex ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
potassium voltage-gated channel subfamily E member 3
Names
minK-related peptide 2
minimum potassium ion channel-related peptide 2
potassium channel subunit beta MiRP2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190869.1NP_001177798.1  potassium voltage-gated channel subfamily E member 3

    See identical proteins and their annotated locations for NP_001177798.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 6. All seven variants encode the same protein.
    Source sequence(s)
    AC121815, AK132773, BY096672
    Consensus CDS
    CCDS21495.1
    UniProtKB/Swiss-Prot
    Q9WTW2
    UniProtKB/TrEMBL
    Q545H9
    Related
    ENSMUSP00000136616.2, ENSMUST00000178946.9
    Conserved Domains (1) summary
    pfam02060
    Location:4896
    ISK_Channel; Slow voltage-gated potassium channel
  2. NM_001190870.1NP_001177799.1  potassium voltage-gated channel subfamily E member 3

    See identical proteins and their annotated locations for NP_001177799.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 6. All seven variants encode the same protein.
    Source sequence(s)
    AC121815
    Consensus CDS
    CCDS21495.1
    UniProtKB/Swiss-Prot
    Q9WTW2
    UniProtKB/TrEMBL
    Q545H9
    Related
    ENSMUSP00000130019.3, ENSMUST00000170954.10
    Conserved Domains (1) summary
    pfam02060
    Location:4896
    ISK_Channel; Slow voltage-gated potassium channel
  3. NM_001190871.2NP_001177800.1  potassium voltage-gated channel subfamily E member 3

    See identical proteins and their annotated locations for NP_001177800.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 6. All seven variants encode the same protein.
    Source sequence(s)
    AC121815, DV056972, EH094997
    Consensus CDS
    CCDS21495.1
    UniProtKB/Swiss-Prot
    Q9WTW2
    UniProtKB/TrEMBL
    Q545H9
    Related
    ENSMUSP00000147047.2, ENSMUST00000208260.2
    Conserved Domains (1) summary
    pfam02060
    Location:4896
    ISK_Channel; Slow voltage-gated potassium channel
  4. NM_001190950.1NP_001177879.1  potassium voltage-gated channel subfamily E member 3

    See identical proteins and their annotated locations for NP_001177879.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 6. All seven variants encode the same protein.
    Source sequence(s)
    AC121815, BX514261, EH094997
    Consensus CDS
    CCDS21495.1
    UniProtKB/Swiss-Prot
    Q9WTW2
    UniProtKB/TrEMBL
    Q545H9
    Related
    ENSMUSP00000147151.2, ENSMUST00000207995.2
    Conserved Domains (1) summary
    pfam02060
    Location:4896
    ISK_Channel; Slow voltage-gated potassium channel
  5. NM_001360466.1NP_001347395.1  potassium voltage-gated channel subfamily E member 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) represents the longest transcript. All seven variants encode the same protein.
    Source sequence(s)
    AC121815
    Consensus CDS
    CCDS21495.1
    UniProtKB/Swiss-Prot
    Q9WTW2
    UniProtKB/TrEMBL
    Q545H9
    Conserved Domains (1) summary
    pfam02060
    Location:4896
    ISK_Channel; Slow voltage-gated potassium channel
  6. NM_001360467.1NP_001347396.1  potassium voltage-gated channel subfamily E member 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 6. All seven variants encode the same protein.
    Source sequence(s)
    AC121815, BM936467
    Consensus CDS
    CCDS21495.1
    UniProtKB/Swiss-Prot
    Q9WTW2
    UniProtKB/TrEMBL
    Q545H9
    Related
    ENSMUSP00000136415.2, ENSMUST00000179842.3
    Conserved Domains (1) summary
    pfam02060
    Location:4896
    ISK_Channel; Slow voltage-gated potassium channel
  7. NM_020574.5NP_065599.1  potassium voltage-gated channel subfamily E member 3

    See identical proteins and their annotated locations for NP_065599.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 6. All seven variants encode the same protein.
    Source sequence(s)
    AC121815, AK008744, EH094997
    Consensus CDS
    CCDS21495.1
    UniProtKB/Swiss-Prot
    Q9WTW2
    UniProtKB/TrEMBL
    Q545H9
    Related
    ENSMUSP00000039353.6, ENSMUST00000049333.13
    Conserved Domains (1) summary
    pfam02060
    Location:4896
    ISK_Channel; Slow voltage-gated potassium channel

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    99825714..99834076
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508062.1XP_006508125.1  potassium voltage-gated channel subfamily E member 3 isoform X1

    See identical proteins and their annotated locations for XP_006508125.1

    UniProtKB/Swiss-Prot
    Q9WTW2
    UniProtKB/TrEMBL
    Q545H9
    Conserved Domains (1) summary
    pfam02060
    Location:4896
    ISK_Channel; Slow voltage-gated potassium channel
  2. XM_006508059.3XP_006508122.1  potassium voltage-gated channel subfamily E member 3 isoform X1

    See identical proteins and their annotated locations for XP_006508122.1

    UniProtKB/Swiss-Prot
    Q9WTW2
    UniProtKB/TrEMBL
    Q545H9
    Conserved Domains (1) summary
    pfam02060
    Location:4896
    ISK_Channel; Slow voltage-gated potassium channel
  3. XM_017322388.1XP_017177877.1  potassium voltage-gated channel subfamily E member 3 isoform X1

    UniProtKB/Swiss-Prot
    Q9WTW2
    UniProtKB/TrEMBL
    Q545H9
    Conserved Domains (1) summary
    pfam02060
    Location:4896
    ISK_Channel; Slow voltage-gated potassium channel