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MIR451A microRNA 451a [ Homo sapiens (human) ]

Gene ID: 574411, updated on 4-Mar-2024


Official Symbol
MIR451Aprovided by HGNC
Official Full Name
microRNA 451aprovided by HGNC
Primary source
See related
Ensembl:ENSG00000284565 MIM:612071; miRBase:MI0001729; AllianceGenome:HGNC:32053
Gene type
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIR451; MIRN451; mir-451a; hsa-mir-451; hsa-mir-451a
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

Exon count:
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (28861369..28861440, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (29804142..29804213, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (27188387..27188458, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 222 member B Neighboring gene ribosomal protein L31 pseudogene 58 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr17:27135759-27136700 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:27139060-27139702 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:27148955-27149456 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:27149457-27149956 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:27164662-27165545 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:27169387-27169901 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8357 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:27181187-27181692 Neighboring gene H3K27ac hESC enhancers GRCh37_chr17:27181693-27182199 and GRCh37_chr17:27182200-27182705 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:27185111-27186310 Neighboring gene uncharacterized LOC124903966 Neighboring gene Era like 12S mitochondrial rRNA chaperone 1 Neighboring gene microRNA 451b Neighboring gene microRNA 4732 Neighboring gene microRNA 144

Genomic regions, transcripts, and products


GeneRIFs: Gene References Into Functions

What's a GeneRIF?


Products Interactant Other Gene Complex Source Pubs Description

General gene information

Other Names

  • microRNA 451

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
enables mRNA base-pairing translational repressor activity IDA
Inferred from Direct Assay
more info

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.


  1. NR_029970.1 RNA Sequence


    Source sequence(s)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly


  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    28861369..28861440 complement
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0


  1. NC_060941.1 Alternate T2T-CHM13v2.0

    29804142..29804213 complement
    GenBank, FASTA, Sequence Viewer (Graphics)