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Gmnn geminin [ Mus musculus (house mouse) ]

Gene ID: 57441, updated on 26-Sep-2022

Summary

Official Symbol
Gmnnprovided by MGI
Official Full Name
gemininprovided by MGI
Primary source
MGI:MGI:1927344
See related
Ensembl:ENSMUSG00000006715 AllianceGenome:MGI:1927344
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gem
Summary
Enables DNA-binding transcription factor binding activity and transcription corepressor activity. Involved in negative regulation of cell cycle; negative regulation of cellular macromolecule biosynthetic process; and protein-containing complex assembly. Acts upstream of or within animal organ morphogenesis. Located in nucleus. Is expressed in several structures, including alimentary system; brain; early embryo; genitourinary system; and respiratory system. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 6. Orthologous to human GMNN (geminin DNA replication inhibitor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E14 (RPKM 43.4), CNS E11.5 (RPKM 31.4) and 12 other tissues See more
Orthologs
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Genomic context

See Gmnn in Genome Data Viewer
Location:
13; 13 A3.1
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (24935828..24954222, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (24751845..24761937, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene RHO family interacting cell polarization regulator 2 Neighboring gene X-linked lymphocyte-regulated 5 pseudogene Neighboring gene armadillo-like helical domain containing 2 Neighboring gene cDNA sequence BC005537 Neighboring gene predicted gene, 22358 Neighboring gene acyl-CoA thioesterase 13

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables histone deacetylase binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
NOT enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020567.2NP_065592.1  geminin

    See identical proteins and their annotated locations for NP_065592.1

    Status: VALIDATED

    Source sequence(s)
    AK131959, BY045588, CF751770
    Consensus CDS
    CCDS26378.1
    UniProtKB/Swiss-Prot
    O88513
    UniProtKB/TrEMBL
    A0A8C6I8X9, Q3V295
    Related
    ENSMUSP00000106011.3, ENSMUST00000110382.9
    Conserved Domains (1) summary
    pfam07412
    Location:1181
    Geminin

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    24935828..24954222 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158101.1XP_036013994.1  geminin isoform X1

    UniProtKB/Swiss-Prot
    O88513
    UniProtKB/TrEMBL
    A0A8C6I8X9, Q3V295
    Conserved Domains (1) summary
    pfam07412
    Location:1181
    Geminin
  2. XM_006516723.4XP_006516786.1  geminin isoform X1

    See identical proteins and their annotated locations for XP_006516786.1

    UniProtKB/Swiss-Prot
    O88513
    UniProtKB/TrEMBL
    A0A8C6I8X9, Q3V295
    Related
    ENSMUSP00000135823.2, ENSMUST00000175689.8
    Conserved Domains (1) summary
    pfam07412
    Location:1181
    Geminin