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APOBEC3G apolipoprotein B mRNA editing enzyme catalytic subunit 3G [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 574398, updated on 12-Dec-2025
Gene symbol
APOBEC3G
Gene description
apolipoprotein B mRNA editing enzyme catalytic subunit 3G
See related
Ensembl:ENSMMUG00000039346
Gene type
protein coding
RefSeq status
INFERRED
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human all
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See APOBEC3G in Genome Data Viewer
Location:
chromosome: 10
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2025_08 current T2T-MMU8v2.0 (GCF_049350105.2) 10 NC_133415.1 (12473843..12484772, complement)
103 previous assembly Mmul_10 (GCF_003339765.1) 10 NC_041763.1 (12488730..12499672, complement)

Chromosome 10 - NC_133415.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC144331718 Neighboring gene apolipoprotein B mRNA editing enzyme catalytic subunit 3H Neighboring gene apolipoprotein B mRNA editing enzyme catalytic subunit 3F Neighboring gene apolipoprotein B mRNA editing enzyme catalytic subunit 3D

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Polymorphisms in the APOBEC3G gene of Chinese rhesus macaques affect resistance to ubiquitination and degradation mediated by HIV-2 Vif. Jiang ZQ, et al. Arch Virol, 2019 May. PMID 30859472
  2. Increased APOBEC3G expression is associated with extensive G-to-A hypermutation in viral DNA in rhesus macaque brain during lentiviral infection. Depboylu C, et al. J Neuropathol Exp Neurol, 2007 Oct. PMID 17917584
  3. Molecular mechanism for regulating APOBEC3G DNA editing function by the non-catalytic domain. Yang H, et al. Nat Commun, 2024 Oct 10. PMID 39389938, Free PMC Article
  4. Antiretroviral activity and Vif sensitivity of rhesus macaque APOBEC3 proteins. Virgen CA, et al. J Virol, 2007 Dec. PMID 17942564, Free PMC Article
  5. Mucosal immunization in macaques upregulates the innate APOBEC 3G anti-viral factor in CD4(+) memory T cells. Wang Y, et al. Vaccine, 2009 Feb 5. PMID 19084567, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Molecular mechanism for regulating APOBEC3G DNA editing function by the non-catalytic domain.
    Title: Molecular mechanism for regulating APOBEC3G DNA editing function by the non-catalytic domain.
  2. Rhesus macaque A3G show different inter-domain packing through a short linker and refolding of CD2 domain.
    Title: Understanding the structural basis of HIV-1 restriction by the full length double-domain APOBEC3G.
  3. The authors found one novel transcript and 10 genetic variants of APOBEC3G, among them, L71R showed resistance to HIV-2-Vif-mediated APOBEC3G degradation, strongly suggesting that L71R could play an important role in the host's antiviral defense.
    Title: Polymorphisms in the APOBEC3G gene of Chinese rhesus macaques affect resistance to ubiquitination and degradation mediated by HIV-2 Vif.
  4. APOBEC3G polymorphism as a selective barrier to cross-species transmission and emergence of pathogenic SIV and AIDS in a primate host.
    Title: APOBEC3G polymorphism as a selective barrier to cross-species transmission and emergence of pathogenic SIV and AIDS in a primate host.
  5. The arginine at position 14 of the SIV Vif is a critical residue for virus restriction by rhA3D, rhA3G and rhA3H.
    Title: Analysis of the N-terminal positively charged residues of the simian immunodeficiency virus Vif reveals a critical amino acid required for the antagonism of rhesus APOBEC3D, G, and H.
  6. APOBEC3F/G-specific responses in HIV-1-infected rhesus macaques are CD8+ T cell mediated.
    Title: T cells target APOBEC3 proteins in human immunodeficiency virus type 1-infected humans and simian immunodeficiency virus-infected Indian rhesus macaques.
  7. Vif proteins of human and simian immunodeficiency viruses require cellular CBFbeta to degrade APOBEC3G.
    Title: Vif proteins of human and simian immunodeficiency viruses require cellular CBFβ to degrade APOBEC3 restriction factors.
  8. simian immunodeficiency virus (SIV) Vif binds to and requires CBF-beta to degrade rhesus macaque APOBEC3G
    Title: Vif hijacks CBF-β to degrade APOBEC3G and promote HIV-1 infection.
  9. Increased APOBEC3G and APOBEC3F expression is associated with low viral load and prolonged survival in simian immunodeficiency virus infected rhesus monkeys.
    Title: Increased APOBEC3G and APOBEC3F expression is associated with low viral load and prolonged survival in simian immunodeficiency virus infected rhesus monkeys.
  10. APOBEC3 proteins restrict xenotropic murine leukemia virus-related virus infections in a Macaca mulatta model.
    Title: In vivo hypermutation of xenotropic murine leukemia virus-related virus DNA in peripheral blood mononuclear cells of rhesus macaque by APOBEC3 proteins.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cytidine deaminase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA cytosine deamination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cytidine to uridine editing IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in defense response to virus IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in P-body IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
DNA dC->dU-editing enzyme APOBEC-3G
Names
apolipoprotein B mRNA editing enzyme, catalytic peptide-like 3G
apolipoprotein B mRNA-editing enzyme catalytic polypeptide 3G
deoxycytidine deaminase
NP_001185622.1
XP_077804145.1
XP_077804146.1
XP_077804147.1
XP_077804148.1
XP_077804150.1
XP_077804151.1
XP_077804152.1
XP_077804153.1
XP_077804154.1
XP_077804155.1
XP_077804156.1
XP_077804157.1
XP_077804158.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198693.2 → NP_001185622.1  DNA dC->dU-editing enzyme APOBEC-3G

    See identical proteins and their annotated locations for NP_001185622.1

    Status: INFERRED

    Source sequence(s)
    DQ913669, DQ913684, QNVO02000021
    UniProtKB/TrEMBL
    U5NDB3, U5NH60
    Related
    ENSMMUP00000073206.1, ENSMMUT00000101598.1
    Conserved Domains (3) summary
    cd01283
    Location:31 → 134
    cytidine_deaminase; Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on ...
    pfam05240
    Location:320 → 364
    APOBEC_C; APOBEC-like C-terminal domain
    pfam08210
    Location:203 → 376
    APOBEC_N; APOBEC-like N-terminal domain

RefSeqs of Annotated Genomes: GCF_049350105.2-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference T2T-MMU8v2.0

Genomic

  1. NC_133415.1 Reference T2T-MMU8v2.0

    Range
    12473843..12484772 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_077948028.1 → XP_077804154.1  DNA dC->dU-editing enzyme APOBEC-3G isoform X5

  2. XM_077948026.1 → XP_077804152.1  DNA dC->dU-editing enzyme APOBEC-3G isoform X5

  3. XM_077948022.1 → XP_077804148.1  DNA dC->dU-editing enzyme APOBEC-3G isoform X3

  4. XM_077948019.1 → XP_077804145.1  DNA dC->dU-editing enzyme APOBEC-3G isoform X1

  5. XM_077948020.1 → XP_077804146.1  DNA dC->dU-editing enzyme APOBEC-3G isoform X2

  6. XM_077948021.1 → XP_077804147.1  DNA dC->dU-editing enzyme APOBEC-3G isoform X1

  7. XM_077948024.1 → XP_077804150.1  DNA dC->dU-editing enzyme APOBEC-3G isoform X3

  8. XM_077948029.1 → XP_077804155.1  DNA dC->dU-editing enzyme APOBEC-3G isoform X5

  9. XM_077948025.1 → XP_077804151.1  DNA dC->dU-editing enzyme APOBEC-3G isoform X4

  10. XM_077948027.1 → XP_077804153.1  DNA dC->dU-editing enzyme APOBEC-3G isoform X5

  11. XM_077948030.1 → XP_077804156.1  DNA dC->dU-editing enzyme APOBEC-3G isoform X5

  12. XM_077948031.1 → XP_077804157.1  DNA dC->dU-editing enzyme APOBEC-3G isoform X5

  13. XM_077948032.1 → XP_077804158.1  DNA dC->dU-editing enzyme APOBEC-3G isoform X5

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7YR23.2 GenPept UniProtKB/Swiss-Prot:Q7YR23

Gene LinkOut

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Research Materials