U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

TLR5 toll like receptor 5 [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 574328, updated on 16-Jun-2026
Official Symbol
TLR5provided by VGNC
Official Full Name
toll like receptor 5provided by VGNC
Primary source
VGNC:VGNC:78376
See related
Ensembl:ENSMMUG00000000870
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See TLR5 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2025_08 current T2T-MMU8v2.0 (GCF_049350105.2) 1 NC_133406.1 (80982028..81021084, complement)
103 previous assembly Mmul_10 (GCF_003339765.1) 1 NC_041754.1 (80784492..80817882, complement)

Chromosome 1 - NC_133406.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC144329632 Neighboring gene uncharacterized LOC144329633 Neighboring gene sushi domain containing 4 Neighboring gene U4 spliceosomal RNA

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Toll-like receptors: insights into their possible role in the pathogenesis of lyme neuroborreliosis. Bernardino AL, et al. Infect Immun, 2008 Oct. PMID 18694963, Free PMC Article
  2. Genetic analysis of Toll/Interleukin-1 Receptor (TIR) domain sequences from rhesus macaque Toll-like receptors (TLRs) 1-10 reveals high homology to human TLR/TIR sequences. Sanghavi SK, et al. Immunogenetics, 2004 Dec. PMID 15578265
  3. Divergent TLR7 and TLR9 signaling and type I interferon production distinguish pathogenic and nonpathogenic AIDS virus infections. Mandl JN, et al. Nat Med, 2008 Oct. PMID 18806803
  4. Natural selection in the TLR-related genes in the course of primate evolution. Nakajima T, et al. Immunogenetics, 2008 Dec. PMID 18810425
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The results indicate that microglia and astrocytes respond to B. burgdorferi through TLR1/2 and TLR5.
    Title: Toll-like receptors: insights into their possible role in the pathogenesis of lyme neuroborreliosis.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in toll-like receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
toll-like receptor 5

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130429.1 → NP_001123901.1  toll-like receptor 5 precursor

    See identical proteins and their annotated locations for NP_001123901.1

    Status: PROVISIONAL

    Source sequence(s)
    AB445651
    UniProtKB/TrEMBL
    B3Y639, B6CJZ5
    Conserved Domains (6) summary
    cd00116
    Location:305 → 567
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:48 → 71
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:290 → 313
    LRR_RI; leucine-rich repeat [structural motif]
    pfam01582
    Location:693 → 837
    TIR; TIR domain
    pfam13855
    Location:288 → 348
    LRR_8; Leucine rich repeat
    cl15307
    Location:579 → 630
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

RefSeqs of Annotated Genomes: GCF_049350105.2-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference T2T-MMU8v2.0

Genomic

  1. NC_133406.1 Reference T2T-MMU8v2.0

    Range
    80982028..81021084 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015114806.3 → XP_014970292.3  toll-like receptor 5 isoform X1

    UniProtKB/TrEMBL
    B6CJZ5

  2. XM_077994267.1 → XP_077850393.1  toll-like receptor 5 isoform X1

    UniProtKB/TrEMBL
    B6CJZ5

  3. XM_077994793.1 → XP_077850919.1  toll-like receptor 5 isoform X1

    UniProtKB/TrEMBL
    B6CJZ5

  4. XM_077995018.1 → XP_077851144.1  toll-like receptor 5 isoform X1

    UniProtKB/TrEMBL
    B6CJZ5

  5. XM_077994860.1 → XP_077850986.1  toll-like receptor 5 isoform X1

    UniProtKB/TrEMBL
    B6CJZ5

  6. XM_077994382.1 → XP_077850508.1  toll-like receptor 5 isoform X1

    UniProtKB/TrEMBL
    B6CJZ5

  7. XM_077995057.1 → XP_077851183.1  toll-like receptor 5 isoform X1

    UniProtKB/TrEMBL
    B6CJZ5

  8. XM_077994977.1 → XP_077851103.1  toll-like receptor 5 isoform X1

    UniProtKB/TrEMBL
    B6CJZ5

  9. XM_077994314.1 → XP_077850440.1  toll-like receptor 5 isoform X1

    UniProtKB/TrEMBL
    B6CJZ5

  10. XM_077994929.1 → XP_077851055.1  toll-like receptor 5 isoform X1

    UniProtKB/TrEMBL
    B6CJZ5

  11. XM_077994646.1 → XP_077850772.1  toll-like receptor 5 isoform X1

    UniProtKB/TrEMBL
    B6CJZ5

  12. XM_077994365.1 → XP_077850491.1  toll-like receptor 5 isoform X1

    UniProtKB/TrEMBL
    B6CJZ5

  13. XM_077994331.1 → XP_077850457.1  toll-like receptor 5 isoform X1

    UniProtKB/TrEMBL
    B6CJZ5

  14. XM_077994585.1 → XP_077850711.1  toll-like receptor 5 isoform X1

    UniProtKB/TrEMBL
    B6CJZ5

  15. XM_077994705.1 → XP_077850831.1  toll-like receptor 5 isoform X1

    UniProtKB/TrEMBL
    B6CJZ5

  16. XM_077994175.1 → XP_077850301.1  toll-like receptor 5 isoform X1

    UniProtKB/TrEMBL
    B6CJZ5

  17. XM_077994526.1 → XP_077850652.1  toll-like receptor 5 isoform X1

    UniProtKB/TrEMBL
    B6CJZ5

  18. XM_077994452.1 → XP_077850578.1  toll-like receptor 5 isoform X1

    UniProtKB/TrEMBL
    B6CJZ5

  19. XM_077994335.1 → XP_077850461.1  toll-like receptor 5 isoform X1

    UniProtKB/TrEMBL
    B6CJZ5

  20. XM_077995139.1 → XP_077851265.1  toll-like receptor 5 isoform X1

    UniProtKB/TrEMBL
    B6CJZ5

  21. XM_077995176.1 → XP_077851302.1  toll-like receptor 5 isoform X1

    UniProtKB/TrEMBL
    B6CJZ5

  22. XM_077995100.1 → XP_077851226.1  toll-like receptor 5 isoform X1

    UniProtKB/TrEMBL
    B6CJZ5

  23. XM_077995227.1 → XP_077851353.1  toll-like receptor 5 isoform X1

    UniProtKB/TrEMBL
    B6CJZ5

  24. XM_028851519.2 → XP_028707352.2  toll-like receptor 5 isoform X1

    UniProtKB/TrEMBL
    B6CJZ5
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials