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Zc3h8 zinc finger CCCH type containing 8 [ Mus musculus (house mouse) ]

Gene ID: 57432, updated on 26-Sep-2022


Official Symbol
Zc3h8provided by MGI
Official Full Name
zinc finger CCCH type containing 8provided by MGI
Primary source
See related
Ensembl:ENSMUSG00000027387 AllianceGenome:MGI:1930128
Gene type
protein coding
RefSeq status
Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fliz1; Zc3hdc8; E130108N08Rik
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including early conceptus; genitourinary system; liver; muscle tissue; and spleen. Orthologous to human ZC3H8 (zinc finger CCCH-type containing 8). [provided by Alliance of Genome Resources, Apr 2022]
Broad expression in CNS E11.5 (RPKM 4.3), CNS E18 (RPKM 4.1) and 24 other tissues See more
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Genomic context

See Zc3h8 in Genome Data Viewer
2; 2 F1
Exon count:
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (128768188..128786018, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (128926268..128944084, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene transmembrane protein 87B Neighboring gene fibulin 7 Neighboring gene predicted gene 14028 Neighboring gene zinc finger CCCH type containing 6

Genomic regions, transcripts, and products


  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a




Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

General gene information



Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in Cajal body ISO
Inferred from Sequence Orthology
more info
located_in euchromatin ISO
Inferred from Sequence Orthology
more info
located_in histone locus body ISO
Inferred from Sequence Orthology
more info
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
located_in nucleus IDA
Inferred from Direct Assay
more info
part_of transcription elongation factor complex ISO
Inferred from Sequence Orthology
more info

General protein information

Preferred Names
zinc finger CCCH domain-containing protein 8
fetal liver zinc finger 1
fetal liver zinc finger 1; putative zinc finger protein FLIZ1
fetal liver zinc finger protein 1
zinc finger CCCH type domain containing 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020594.2NP_065619.2  zinc finger CCCH domain-containing protein 8

    See identical proteins and their annotated locations for NP_065619.2

    Status: VALIDATED

    Source sequence(s)
    BC048687, CJ167668
    Consensus CDS
    Q80X92, Q9JJ48
    ENSMUSP00000028866.9, ENSMUST00000028866.9
    Conserved Domains (1) summary
    ZnF_C3H1; zinc finger

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J


  1. NC_000068.8 Reference GRCm39 C57BL/6J

    128768188..128786018 complement
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499947.3XP_006500010.1  zinc finger CCCH domain-containing protein 8 isoform X1

    Conserved Domains (1) summary
    YTH1; Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin family Zn-finger proteins [General function prediction only]