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LDLR low density lipoprotein receptor [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 574283, updated on 17-Aug-2024

Summary

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Official Symbol
LDLRprovided by VGNC
Official Full Name
low density lipoprotein receptorprovided by VGNC
Primary source
VGNC:VGNC:74248
See related
Ensembl:ENSMMUG00000003611
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See LDLR in Genome Data Viewer
Location:
chromosome: 19
Exon count:
18
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 19 NC_041772.1 (10851254..10893727)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 19 NC_027911.1 (11109832..11154562)

Chromosome 19 - NC_041772.1Genomic Context describing neighboring genes Neighboring gene translocase of inner mitochondrial membrane 29 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 Neighboring gene uncharacterized LOC114674158 Neighboring gene SPC24 component of NDC80 kinetochore complex Neighboring gene KN motif and ankyrin repeat domains 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Uptake of cholesterol by the retina occurs primarily via a low density lipoprotein receptor-mediated process. Tserentsoodol N, et al. Mol Vis, 2006 Oct 27. PMID 17110914
  2. Low-density lipoprotein receptor gene therapy using helper-dependent adenovirus produces long-term protection against atherosclerosis in a mouse model of familial hypercholesterolemia. Nomura S, et al. Gene Ther, 2004 Oct. PMID 15269711
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
low-density lipoprotein receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001032906.1 → NP_001028078.1  low-density lipoprotein receptor precursor

    See identical proteins and their annotated locations for NP_001028078.1

    Status: PROVISIONAL

    Source sequence(s)
    AY466854
    UniProtKB/TrEMBL
    A0A1D5RIY9, Q6S4M2
    Related
    ENSMMUP00000004821.4, ENSMMUT00000005117.4
    Conserved Domains (5) summary
    smart00135
    Location:546 → 588
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:347 → 381
    EGF_CA; Calcium-binding EGF-like domain
    pfam00057
    Location:195 → 231
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:522 → 562
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:311 → 339
    FXa_inhibition; Coagulation Factor Xa inhibitory site

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041772.1 Reference Mmul_10 Primary Assembly

    Range
    10851254..10893727
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_028838328.1 → XP_028694161.1  low-density lipoprotein receptor isoform X1

    UniProtKB/TrEMBL
    A0A1D5RIY9
    Conserved Domains (5) summary
    smart00135
    Location:553 → 595
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:354 → 388
    EGF_CA; Calcium-binding EGF-like domain
    pfam00058
    Location:529 → 569
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam00057
    Location:195 → 231
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam14670
    Location:318 → 346
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  2. XM_015122900.2 → XP_014978386.2  low-density lipoprotein receptor isoform X2

    UniProtKB/TrEMBL
    A0A1D5RIY9, F6QFM0
    Related
    ENSMMUP00000004819.4, ENSMMUT00000005115.4
    Conserved Domains (5) summary
    smart00135
    Location:553 → 595
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:354 → 388
    EGF_CA; Calcium-binding EGF-like domain
    pfam00058
    Location:529 → 569
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam00057
    Location:195 → 231
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam14670
    Location:318 → 346
    FXa_inhibition; Coagulation Factor Xa inhibitory site
Nucleotide Protein
Heading Accession and Version

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