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WDR18 WD repeat domain 18 [ Homo sapiens (human) ]

Gene ID: 57418, updated on 13-Mar-2020

Summary

Official Symbol
WDR18provided by HGNC
Official Full Name
WD repeat domain 18provided by HGNC
Primary source
HGNC:HGNC:17956
See related
Ensembl:ENSG00000065268
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Ipi3; R32184_1
Summary
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in kidney (RPKM 9.8), colon (RPKM 5.8) and 25 other tissues See more
Orthologs

Genomic context

See WDR18 in Genome Data Viewer
Location:
19p13.3
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (982928..994557)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (984328..994569)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene AT-rich interaction domain 3A Neighboring gene HNF4 motif-containing MPRA enhancer 174 Neighboring gene uncharacterized LOC105372235 Neighboring gene glutamate ionotropic receptor NMDA type subunit 3B Neighboring gene transmembrane protein 259

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC2436

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
rRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
rRNA processing TAS
Traceable Author Statement
more info
 
regulation of DNA-dependent DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Rix1 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nuclear pre-replicative complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleolus IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
WD repeat-containing protein 18
Names
Involved in Processing ITS2 3 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001372085.1NP_001359014.1  WD repeat-containing protein 18 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC005391, BC000040, BC001648, BU154887
  2. NM_001372086.1NP_001359015.1  WD repeat-containing protein 18 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC005391, BC000040, BC001648, BU154887
  3. NM_024100.4NP_077005.2  WD repeat-containing protein 18 isoform 1

    See identical proteins and their annotated locations for NP_077005.2

    Status: VALIDATED

    Source sequence(s)
    BC000040, BC001648, BU154887
    Consensus CDS
    CCDS12051.1
    UniProtKB/Swiss-Prot
    Q9BV38
    Related
    ENSP00000476117.2, ENST00000585809.5
    Conserved Domains (4) summary
    COG2319
    Location:19314
    WD40; WD40 repeat [General function prediction only]
    pfam14077
    Location:383430
    WD40_alt; Alternative WD40 repeat motif
    sd00039
    Location:84119
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:19297
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    982928..994557
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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