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CD40LG CD40 ligand [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 574160, updated on 17-Dec-2025
Official Symbol
CD40LGprovided by VGNC
Official Full Name
CD40 ligandprovided by VGNC
Primary source
VGNC:VGNC:70704
See related
Ensembl:ENSMMUG00000013773
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Also known as
CD40L
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See CD40LG in Genome Data Viewer
Location:
chromosome: X
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2025_08 current T2T-MMU8v2.0 (GCF_049350105.2) X NC_133426.1 (142984623..142996020)
103 previous assembly Mmul_10 (GCF_003339765.1) X NC_041774.1 (132757121..132768518)

Chromosome X - NC_133426.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC106995333 Neighboring gene Rac/Cdc42 guanine nucleotide exchange factor 6 Neighboring gene uncharacterized LOC144338735 Neighboring gene uncharacterized LOC144338732

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Macaque multimeric soluble CD40 ligand and GITR ligand constructs are immunostimulatory molecules in vitro. Stone GW, et al. Clin Vaccine Immunol, 2006 Nov. PMID 16988005, Free PMC Article
  2. Cloning, sequencing, and homology analysis of nonhuman primate Fas/Fas-ligand and co-stimulatory molecules. Villinger F, et al. Immunogenetics, 2001 May-Jun. PMID 11491535
  3. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Both two-trimer and four-trimer forms of macaque CD40L were active in B-cell proliferation assays using macaque and human cells.
    Title: Macaque multimeric soluble CD40 ligand and GITR ligand constructs are immunostimulatory molecules in vitro.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables CD40 receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables tumor necrosis factor receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
CD40 ligand
Names
CD154 protein
CD40 ligand (TNF superfamily, member 5, hyper-IgM syndrome)
CD40-L
tumor necrosis factor ligand superfamily member 5

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001032839.1 → NP_001028011.1  CD40 ligand

    See identical proteins and their annotated locations for NP_001028011.1

    Status: PROVISIONAL

    Source sequence(s)
    AF344859
    UniProtKB/Swiss-Prot
    P63304
    UniProtKB/TrEMBL
    A0A8J8XRR8, F6Q0N6, G7NRP8
    Related
    ENSMMUP00000040794.2, ENSMMUT00000047767.3
    Conserved Domains (1) summary
    smart00207
    Location:138 → 261
    TNF; Tumour necrosis factor family

RefSeqs of Annotated Genomes: GCF_049350105.2-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference T2T-MMU8v2.0

Genomic

  1. NC_133426.1 Reference T2T-MMU8v2.0

    Range
    142984623..142996020
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P63304.1 GenPept UniProtKB/Swiss-Prot:P63304

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials