OPRM1 opioid receptor mu 1 [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Official Symbol: OPRM1provided by VGNC
Official Full Name: opioid receptor mu 1provided by VGNC
Primary source: VGNC:VGNC:83440
See related: Ensembl:ENSMMUG00000022691
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs: all
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Genomic context

Location:: chromosome: 4

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2025_08	current	T2T-MMU8v2.0 (GCF_049350105.2)	4	NC_133409.1 (72846503..72933856)
103	previous assembly	Mmul_10 (GCF_003339765.1)	4	NC_041757.1 (60275359..60397879)

Chromosome 4 - NC_133409.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A nonsynonymous SNP in the first exon of the OPRM1 gene (OPRM1 A118G) encodes the ligand-binding domain the receptor and which has been associated with increased alcohol-induced stimulation and euphoria.
Title: OPRM1 genotype interacts with serotonin system dysfunction to predict alcohol-heightened aggression in primates.
Coactivation of mu opioid receptors with nociceptin receptors produces synergistic antinociception.
Title: Roles of μ-opioid receptors and nociceptin/orphanin FQ peptide receptors in buprenorphine-induced physiological responses in primates.
Thisstudy adds to the growing literature showing that variation in the mu-opioid receptor gene OPRM1 is associated with social attachment and rejection.
Title: Mu-opioid receptor (OPRM1) variation, oxytocin levels and maternal attachment in free-ranging rhesus macaques Macaca mulatta.
OPRM1 gene variation influences hypothalamic-pituitary-adrenal axis function in response to a variety of stressors.
Title: OPRM1 gene variation influences hypothalamic-pituitary-adrenal axis function in response to a variety of stressors in rhesus macaques.
findings suggest a role for OPRM1 variation in the expression of attachment behavior, especially as a function of separation from the caregiver
Title: Variation at the mu-opioid receptor gene (OPRM1) influences attachment behavior in infant primates.

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General gene information

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Markers

RH70574 (e-PCR)
- UniSTS:87561

D6S1836 (e-PCR)
- UniSTS:28223

OPRM1 (e-PCR)
- UniSTS:479916

SHGC-84785 (e-PCR)
- UniSTS:104160

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables G-protein alpha-subunit binding	IEA Inferred from Electronic Annotation more info	PubMed
enables G-protein beta-subunit binding	IEA Inferred from Electronic Annotation more info	PubMed
enables beta-endorphin receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables morphine receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables neuropeptide binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled opioid receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in sensory perception of pain	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in neuron projection	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: mu-type opioid receptor

Names: M-OR-1; MOR-1; mu opioid receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.