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TYK2 tyrosine kinase 2 [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 574130, updated on 5-Mar-2024

Summary

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Official Symbol
TYK2provided by VGNC
Official Full Name
tyrosine kinase 2provided by VGNC
Primary source
VGNC:VGNC:78680
See related
Ensembl:ENSMMUG00000003110
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See TYK2 in Genome Data Viewer
Location:
chromosome: 19
Exon count:
25
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 19 NC_041772.1 (10110204..10144759, complement)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 19 NC_027911.1 (10382269..10418074, complement)

Chromosome 19 - NC_041772.1Genomic Context describing neighboring genes Neighboring gene ferredoxin 2 Neighboring gene ribonucleoprotein, PTB binding 1 Neighboring gene intercellular adhesion molecule 3 Neighboring gene cell division cycle 37, HSP90 cochaperone Neighboring gene phosphodiesterase 4A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cytokine receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
non-receptor tyrosine-protein kinase TYK2
XP_028695770.1
XP_028695771.1
XP_028695772.1
XP_028695773.1
XP_028695774.1
XP_028695775.1
XP_028695777.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041772.1 Reference Mmul_10 Primary Assembly

    Range
    10110204..10144759 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_028839941.1 → XP_028695774.1  non-receptor tyrosine-protein kinase TYK2 isoform X2

    UniProtKB/TrEMBL
    A0A5F7ZPU9, H9Z2G6
    Related
    ENSMMUP00000067206.1, ENSMMUT00000082366.1
    Conserved Domains (5) summary
    smart00295
    Location:28 → 273
    B41; Band 4.1 homologues
    cd05076
    Location:589 → 867
    PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    cd05080
    Location:892 → 1174
    PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    cl15255
    Location:437 → 534
    SH2; Src homology 2 (SH2) domain
    cl17171
    Location:270 → 437
    PH-like; Pleckstrin homology-like domain

  2. XM_028839942.1 → XP_028695775.1  non-receptor tyrosine-protein kinase TYK2 isoform X3

    UniProtKB/TrEMBL
    A0A5F7ZDF4
    Related
    ENSMMUP00000063209.1, ENSMMUT00000105130.1
    Conserved Domains (4) summary
    smart00295
    Location:28 → 273
    B41; Band 4.1 homologues
    cl15255
    Location:437 → 534
    SH2; Src homology 2 (SH2) domain
    cl17171
    Location:270 → 437
    PH-like; Pleckstrin homology-like domain
    cl21453
    Location:589 → 867
    PKc_like; Protein Kinases, catalytic domain

  3. XM_028839937.1 → XP_028695770.1  non-receptor tyrosine-protein kinase TYK2 isoform X1

    UniProtKB/TrEMBL
    A0A5F7ZPU9, F7DRD4, H9ZD33
    Conserved Domains (5) summary
    smart00295
    Location:28 → 273
    B41; Band 4.1 homologues
    cd05076
    Location:589 → 867
    PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    cd05080
    Location:895 → 1177
    PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    cl15255
    Location:437 → 534
    SH2; Src homology 2 (SH2) domain
    cl17171
    Location:270 → 437
    PH-like; Pleckstrin homology-like domain

  4. XM_028839940.1 → XP_028695773.1  non-receptor tyrosine-protein kinase TYK2 isoform X1

    UniProtKB/TrEMBL
    A0A5F7ZPU9, F7DRD4, H9ZD33
    Conserved Domains (5) summary
    smart00295
    Location:28 → 273
    B41; Band 4.1 homologues
    cd05076
    Location:589 → 867
    PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    cd05080
    Location:895 → 1177
    PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    cl15255
    Location:437 → 534
    SH2; Src homology 2 (SH2) domain
    cl17171
    Location:270 → 437
    PH-like; Pleckstrin homology-like domain

  5. XM_028839938.1 → XP_028695771.1  non-receptor tyrosine-protein kinase TYK2 isoform X1

    UniProtKB/TrEMBL
    A0A5F7ZPU9, F7DRD4, H9ZD33
    Conserved Domains (5) summary
    smart00295
    Location:28 → 273
    B41; Band 4.1 homologues
    cd05076
    Location:589 → 867
    PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    cd05080
    Location:895 → 1177
    PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    cl15255
    Location:437 → 534
    SH2; Src homology 2 (SH2) domain
    cl17171
    Location:270 → 437
    PH-like; Pleckstrin homology-like domain

  6. XM_028839939.1 → XP_028695772.1  non-receptor tyrosine-protein kinase TYK2 isoform X1

    UniProtKB/TrEMBL
    A0A5F7ZPU9, F7DRD4, H9ZD33
    Related
    ENSMMUP00000004150.4, ENSMMUT00000004400.4
    Conserved Domains (5) summary
    smart00295
    Location:28 → 273
    B41; Band 4.1 homologues
    cd05076
    Location:589 → 867
    PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    cd05080
    Location:895 → 1177
    PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    cl15255
    Location:437 → 534
    SH2; Src homology 2 (SH2) domain
    cl17171
    Location:270 → 437
    PH-like; Pleckstrin homology-like domain

  7. XM_028839944.1 → XP_028695777.1  non-receptor tyrosine-protein kinase TYK2 isoform X4

    UniProtKB/TrEMBL
    A0A5F7ZPU9
    Conserved Domains (4) summary
    smart00295
    Location:28 → 273
    B41; Band 4.1 homologues
    cl15255
    Location:437 → 534
    SH2; Src homology 2 (SH2) domain
    cl17171
    Location:270 → 437
    PH-like; Pleckstrin homology-like domain
    cl21453
    Location:589 → 867
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version

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