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IL6ST interleukin 6 cytokine family signal transducer [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 574127, updated on 5-Mar-2024

Summary

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Official Symbol
IL6STprovided by VGNC
Official Full Name
interleukin 6 cytokine family signal transducerprovided by VGNC
Primary source
VGNC:VGNC:73734
Locus tag
EGK_16499
See related
Ensembl:ENSMMUG00000001893
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Also known as
IL-6
Orthologs
human mouse all
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Genomic context

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See IL6ST in Genome Data Viewer
Location:
chromosome: 6
Exon count:
19
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 6 NC_041759.1 (54242537..54300162, complement)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 6 NC_027898.1 (56855645..56913125, complement)

Chromosome 6 - NC_041759.1Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein H-like Neighboring gene interleukin 31 receptor A Neighboring gene 40S ribosomal protein S2 pseudogene Neighboring gene uncharacterized LOC114678788 Neighboring gene ankyrin repeat domain 55 Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cytokine binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cytokine receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of tyrosine phosphorylation of STAT protein IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of CRLF-CLCF1 complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
interleukin-6 receptor subunit beta
Names
interleukin 6 signal transducer (gp130, oncostatin M receptor)
interleukin 6 signal transducer receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001265991.1 → NP_001252920.1  interleukin-6 receptor subunit beta precursor

    See identical proteins and their annotated locations for NP_001252920.1

    Status: PROVISIONAL

    Source sequence(s)
    JV043653
    UniProtKB/TrEMBL
    A0A5F8A6Y8, A0A8J8YAN3, F7FXB6, G7MTS1
    Related
    ENSMMUP00000073139.1, ENSMMUT00000109616.1
    Conserved Domains (4) summary
    smart00060
    Location:519 → 599
    FN3; Fibronectin type 3 domain
    cd00063
    Location:222 → 321
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:26 → 112
    Lep_receptor_Ig; Ig-like C2-type domain
    cl21522
    Location:131 → 216
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041759.1 Reference Mmul_10 Primary Assembly

    Range
    54242537..54300162 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015140023.2 → XP_014995509.1  interleukin-6 receptor subunit beta isoform X2

    UniProtKB/TrEMBL
    F7FX97, F7FXB6
    Related
    ENSMMUP00000002529.3, ENSMMUT00000002677.3
    Conserved Domains (4) summary
    smart00060
    Location:458 → 538
    FN3; Fibronectin type 3 domain
    cd00063
    Location:222 → 321
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:26 → 112
    Lep_receptor_Ig; Ig-like C2-type domain
    cl21522
    Location:131 → 216
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  2. XM_015140022.2 → XP_014995508.1  interleukin-6 receptor subunit beta isoform X1

    UniProtKB/TrEMBL
    F7FXB6
    Related
    ENSMMUP00000002524.3, ENSMMUT00000002672.4
    Conserved Domains (4) summary
    smart00060
    Location:525 → 605
    FN3; Fibronectin type 3 domain
    cd00063
    Location:228 → 327
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:32 → 118
    Lep_receptor_Ig; Ig-like C2-type domain
    cl21522
    Location:135 → 222
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  3. XM_028849016.1 → XP_028704849.1  interleukin-6 receptor subunit beta isoform X3

    Conserved Domains (1) summary
    smart00060
    Location:230 → 310
    FN3; Fibronectin type 3 domain
Nucleotide Protein
Heading Accession and Version

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