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AS3MT arsenite methyltransferase [ Homo sapiens (human) ]

Gene ID: 57412, updated on 12-Aug-2018

Summary

Official Symbol
AS3MTprovided by HGNC
Official Full Name
arsenite methyltransferaseprovided by HGNC
Primary source
HGNC:HGNC:17452
See related
Ensembl:ENSG00000214435 MIM:611806; Vega:OTTHUMG00000018972
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CYT19
Summary
AS3MT catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to trivalent arsenical and may play a role in arsenic metabolism (Lin et al., 2002 [PubMed 11790780]).[supplied by OMIM, Mar 2008]
Expression
Biased expression in adrenal (RPKM 88.8), liver (RPKM 11.0) and 5 other tissues See more
Orthologs

Genomic context

See AS3MT in Genome Data Viewer
Location:
10q24.32
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 10 NC_000010.11 (102869453..102901899)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (104629183..104661656)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene BORCS7-ASMT readthrough (NMD candidate) Neighboring gene prostaglandin E synthase 3 pseudogene 4 Neighboring gene profilin 1 pseudogene 11 Neighboring gene BLOC-1 related complex subunit 7 Neighboring gene translation initiation factor IF-2-like Neighboring gene ribosomal protein L22 pseudogene 17 Neighboring gene cyclin and CBS domain divalent metal cation transport mediator 2 Neighboring gene 5'-nucleotidase, cytosolic II Neighboring gene ribosomal protein S15a pseudogene 29

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A comprehensive family-based replication study of schizophrenia genes.
NHGRI GWA Catalog
Biological insights from 108 schizophrenia-associated genetic loci.
NHGRI GWA Catalog
Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia.
NHGRI GWA Catalog
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
NHGRI GWA Catalog
Genome-wide association study identifies chromosome 10q24.32 variants associated with arsenic metabolism and toxicity phenotypes in Bangladesh.
NHGRI GWA Catalog
Genome-wide association study identifies eight loci associated with blood pressure.
NHGRI GWA Catalog
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
NHGRI GWA Catalog
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
NHGRI GWA Catalog

Pathways from BioSystems

  • Biological oxidations, organism-specific biosystem (from REACTOME)
    Biological oxidations, organism-specific biosystemAll organisms are constantly exposed to foreign chemicals every day. These can be man-made (drugs, industrial chemicals) or natural (alkaloids, toxins from plants and animals). Uptake is usually via ...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Methylation, organism-specific biosystem (from REACTOME)
    Methylation, organism-specific biosystemMethylation is a common but minor pathway of Phase II conjugation compared to glucuronidation or sulfonation. The cofactor used in methylation conjugation is S-adenosylmethionine (SAM). SAM is the ...
  • Phase II conjugation, organism-specific biosystem (from REACTOME)
    Phase II conjugation, organism-specific biosystemPhase II of biotransformation is concerned with conjugation, that is using groups from cofactors to react with functional groups present or introduced from phase I on the compound. The enzymes involv...
  • arsenate detoxification I (glutaredoxin), organism-specific biosystem (from BIOCYC)
    arsenate detoxification I (glutaredoxin), organism-specific biosystemGeneral Background While the jury is still out about whether Napoleon Bonaparte died of arsenic poisoning or cancer , it is agreed by all that arsenic is a potent toxicant. Indeed, the results of ex...
  • arsenate detoxification I (glutaredoxin), conserved biosystem (from BIOCYC)
    arsenate detoxification I (glutaredoxin), conserved biosystemGeneral Background While the jury is still out about whether Napoleon Bonaparte died of arsenic poisoning or cancer |CITS: [367316] [6750413]|, it is agreed by all that arsenic is a potent toxicant....

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough BORCS7-ASMT

Readthrough gene: BORCS7-ASMT, Included gene: BORCS7

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
arsenite methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
arsenite methyltransferase activity TAS
Traceable Author Statement
more info
 
methylarsonite methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
arsonoacetate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
methylation TAS
Traceable Author Statement
more info
 
toxin metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
arsenite methyltransferase
Names
S-adenosyl-L-methionine:arsenic(III) methyltransferase
S-adenosylmethionine:arsenic (III) methyltransferase
arsenic (+3 oxidation state) methyltransferase
methylarsonite methyltransferase
methyltransferase cyt19
NP_065733.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020682.3NP_065733.2  arsenite methyltransferase

    See identical proteins and their annotated locations for NP_065733.2

    Status: VALIDATED

    Source sequence(s)
    AL358790, AW139845, BC119638, DA368970
    Consensus CDS
    CCDS41567.1
    UniProtKB/Swiss-Prot
    Q9HBK9
    Related
    ENSP00000358896.3, OTTHUMP00000020384, ENST00000369880.7, OTTHUMT00000050107
    Conserved Domains (2) summary
    PRK11873
    Location:6254
    arsM; arsenite S-adenosylmethyltransferase; Reviewed
    pfam13847
    Location:74182
    Methyltransf_31; Methyltransferase domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p12 Primary Assembly

    Range
    102869453..102901899
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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