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AS3MT arsenite methyltransferase [ Homo sapiens (human) ]

Gene ID: 57412, updated on 13-May-2022

Summary

Official Symbol
AS3MTprovided by HGNC
Official Full Name
arsenite methyltransferaseprovided by HGNC
Primary source
HGNC:HGNC:17452
See related
Ensembl:ENSG00000214435 MIM:611806; AllianceGenome:HGNC:17452
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CYT19
Summary
AS3MT catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to trivalent arsenical and may play a role in arsenic metabolism (Lin et al., 2002 [PubMed 11790780]).[supplied by OMIM, Mar 2008]
Expression
Biased expression in adrenal (RPKM 88.8), liver (RPKM 11.0) and 5 other tissues See more
Orthologs
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Genomic context

See AS3MT in Genome Data Viewer
Location:
10q24.32
Exon count:
11
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (102869470..102901899)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (103755254..103787669)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (104629227..104661656)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene BORCS7-ASMT readthrough (NMD candidate) Neighboring gene U6 spliceosomal RNA Neighboring gene BLOC-1 related complex subunit 7 Neighboring gene uncharacterized LOC107984265 Neighboring gene ribosomal protein L22 pseudogene 17 Neighboring gene Sharpr-MPRA regulatory region 3077 Neighboring gene cyclin and CBS domain divalent metal cation transport mediator 2 Neighboring gene Sharpr-MPRA regulatory region 2614

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A comprehensive family-based replication study of schizophrenia genes.
EBI GWAS Catalog
Biological insights from 108 schizophrenia-associated genetic loci.
EBI GWAS Catalog
Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia.
EBI GWAS Catalog
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
EBI GWAS Catalog
Genome-wide association study identifies chromosome 10q24.32 variants associated with arsenic metabolism and toxicity phenotypes in Bangladesh.
EBI GWAS Catalog
Genome-wide association study identifies eight loci associated with blood pressure.
EBI GWAS Catalog
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
EBI GWAS Catalog
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough BORCS7-ASMT

Readthrough gene: BORCS7-ASMT, Included gene: BORCS7

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables arsenite methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables arsenite methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables arsenite methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables arsenite methyltransferase activity TAS
Traceable Author Statement
more info
 
enables methylarsonite methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables methylarsonite methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in arsonoacetate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in arsonoacetate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in methylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in methylation TAS
Traceable Author Statement
more info
 
involved_in toxin metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in toxin metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
arsenite methyltransferase
Names
S-adenosyl-L-methionine:arsenic(III) methyltransferase
S-adenosylmethionine:arsenic (III) methyltransferase
arsenic (+3 oxidation state) methyltransferase
methylarsonite methyltransferase
methyltransferase cyt19
NP_065733.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020682.4NP_065733.2  arsenite methyltransferase

    See identical proteins and their annotated locations for NP_065733.2

    Status: VALIDATED

    Source sequence(s)
    AL358790, AW139845, BC119638, DA368970
    Consensus CDS
    CCDS41567.1
    UniProtKB/Swiss-Prot
    Q9HBK9
    Related
    ENSP00000358896.3, ENST00000369880.8
    Conserved Domains (2) summary
    PRK11873
    Location:6254
    arsM; arsenite S-adenosylmethyltransferase; Reviewed
    pfam13847
    Location:74182
    Methyltransf_31; Methyltransferase domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    102869470..102901899
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    103755254..103787669
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)