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NMRAL1 NmrA like redox sensor 1 [ Homo sapiens (human) ]

Gene ID: 57407, updated on 8-Oct-2018

Summary

Official Symbol
NMRAL1provided by HGNC
Official Full Name
NmrA like redox sensor 1provided by HGNC
Primary source
HGNC:HGNC:24987
See related
Ensembl:ENSG00000153406 Vega:OTTHUMG00000129468
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSCARG; SDR48A1
Summary
This gene encodes an NADPH sensor protein that preferentially binds to NADPH. The encoded protein also negatively regulates the activity of NF-kappaB in a ubiquitylation-dependent manner. It plays a key role in cellular antiviral response by negatively regulating the interferon response factor 3-mediated expression of interferon beta. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Expression
Ubiquitous expression in prostate (RPKM 6.2), ovary (RPKM 6.2) and 25 other tissues See more
Orthologs

Genomic context

See NMRAL1 in Genome Data Viewer
Location:
16p13.3
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (4461680..4476337, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (4511690..4524896, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene CORO7-PAM16 readthrough Neighboring gene coronin 7 Neighboring gene vasorin Neighboring gene DnaJ heat shock protein family (Hsp40) member A3 Neighboring gene heme oxygenase 2 Neighboring gene cell death inducing p53 target 1 Neighboring gene chromosome 16 open reading frame 96 Neighboring gene SUB1 homolog, transcriptional regulator pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of amino acids and derivatives, organism-specific biosystem (from REACTOME)
    Metabolism of amino acids and derivatives, organism-specific biosystemThis group of reactions is responsible for: 1) the breakdown of amino acids; 2) the synthesis of urea from ammonia and amino groups generated by amino acid breakdown; 3) the synthesis of the ten amin...
  • Metabolism of polyamines, organism-specific biosystem (from REACTOME)
    Metabolism of polyamines, organism-specific biosystemPolyamines is a family of molecules (i.e. putrescine, spermine, spermidine) derived from ornithine according to a decarboxylation/condensative process. More recently, it has been demonstrated that ar...
  • Urea cycle, organism-specific biosystem (from REACTOME)
    Urea cycle, organism-specific biosystemThe urea cycle yields urea, the major form in which excess nitrogen is excreted from the human body, and the amino acid arginine (Brusilow and Horwich 2001). It consists of four reactions: that of or...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ25918

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
nmrA-like family domain-containing protein 1
Names
NmrA-like family domain containing 1
epididymis secretory sperm binding protein
short chain dehydrogenase/reductase family 48A, member 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305141.2NP_001292070.1  nmrA-like family domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001292070.1

    Status: REVIEWED

    Source sequence(s)
    AC012676, AW246763, BC002927, HY171572
    Consensus CDS
    CCDS10516.1
    UniProtKB/Swiss-Prot
    Q9HBL8
    Related
    ENSP00000383962.3, OTTHUMP00000257485, ENST00000404295.7
    Conserved Domains (1) summary
    cd08947
    Location:7241
    NmrA_TMR_like_SDR_a; NmrA (a transcriptional regulator), HSCARG (an NADPH sensor), and triphenylmethane reductase (TMR) like proteins, atypical (a) SDRs
  2. NM_001305142.2NP_001292071.1  nmrA-like family domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001292071.1

    Status: REVIEWED

    Source sequence(s)
    AC012676, AK098784, AW246763, HY171572
    Consensus CDS
    CCDS10516.1
    UniProtKB/Swiss-Prot
    Q9HBL8
    Related
    ENSP00000460263.1, OTTHUMP00000257486, ENST00000574425.5
    Conserved Domains (1) summary
    cd08947
    Location:7241
    NmrA_TMR_like_SDR_a; NmrA (a transcriptional regulator), HSCARG (an NADPH sensor), and triphenylmethane reductase (TMR) like proteins, atypical (a) SDRs
  3. NM_001351994.1NP_001338923.1  nmrA-like family domain-containing protein 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC007606, AC012676, AW246763
    Consensus CDS
    CCDS10516.1
    Related
    ENSP00000458762.1, ENST00000574733.5
    Conserved Domains (1) summary
    cd08947
    Location:7241
    NmrA_TMR_like_SDR_a; NmrA (a transcriptional regulator), HSCARG (an NADPH sensor), and triphenylmethane reductase (TMR) like proteins, atypical (a) SDRs
  4. NM_001351995.1NP_001338924.1  nmrA-like family domain-containing protein 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC007606, AC012676, AW246763
    Conserved Domains (1) summary
    cl25409
    Location:30178
    SDR; Short-chain dehydrogenases/reductases (SDR)
  5. NM_001351996.1NP_001338925.1  nmrA-like family domain-containing protein 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC007606, AC012676, AW246763
    Conserved Domains (1) summary
    cd05251
    Location:7175
    NmrA_like_SDR_a; NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs
  6. NM_020677.5NP_065728.1  nmrA-like family domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_065728.1

    Status: REVIEWED

    Source sequence(s)
    AC012676, AF225419, AW246763
    Consensus CDS
    CCDS10516.1
    UniProtKB/Swiss-Prot
    Q9HBL8
    Related
    ENSP00000283429.6, OTTHUMP00000159842, ENST00000283429.10
    Conserved Domains (1) summary
    cd08947
    Location:7241
    NmrA_TMR_like_SDR_a; NmrA (a transcriptional regulator), HSCARG (an NADPH sensor), and triphenylmethane reductase (TMR) like proteins, atypical (a) SDRs

RNA

  1. NR_147845.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007606, AC012676, AW246763

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    4461680..4476337 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017023491.1XP_016878980.1  nmrA-like family domain-containing protein 1 isoform X7

  2. XM_006720905.4XP_006720968.1  nmrA-like family domain-containing protein 1 isoform X5

    See identical proteins and their annotated locations for XP_006720968.1

    Conserved Domains (1) summary
    cl25409
    Location:30178
    SDR; Short-chain dehydrogenases/reductases (SDR)
  3. XM_024450360.1XP_024306128.1  nmrA-like family domain-containing protein 1 isoform X8

    Related
    ENSP00000459221.1, ENST00000572232.5
    Conserved Domains (1) summary
    cl25409
    Location:195
    SDR; Short-chain dehydrogenases/reductases (SDR)
  4. XM_006720906.2XP_006720969.1  nmrA-like family domain-containing protein 1 isoform X6

    See identical proteins and their annotated locations for XP_006720969.1

    Conserved Domains (2) summary
    COG0451
    Location:72181
    WcaG; Nucleoside-diphosphate-sugar epimerase [Cell wall/membrane/envelope biogenesis]
    cl21454
    Location:1177
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  5. XM_017023489.1XP_016878978.1  nmrA-like family domain-containing protein 1 isoform X6

    Conserved Domains (2) summary
    COG0451
    Location:72181
    WcaG; Nucleoside-diphosphate-sugar epimerase [Cell wall/membrane/envelope biogenesis]
    cl21454
    Location:1177
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  6. XM_017023485.1XP_016878974.1  nmrA-like family domain-containing protein 1 isoform X1

    Related
    OTTHUMP00000257482, OTTHUMT00000438579
    Conserved Domains (2) summary
    cd08947
    Location:43277
    NmrA_TMR_like_SDR_a; NmrA (a transcriptional regulator), HSCARG (an NADPH sensor), and triphenylmethane reductase (TMR) like proteins, atypical (a) SDRs
    COG0702
    Location:41242
    YbjT; Uncharacterized conserved protein YbjT, contains NAD(P)-binding and DUF2867 domains [General function prediction only]
  7. XM_017023488.2XP_016878977.1  nmrA-like family domain-containing protein 1 isoform X4

    Conserved Domains (2) summary
    cd08947
    Location:7240
    NmrA_TMR_like_SDR_a; NmrA (a transcriptional regulator), HSCARG (an NADPH sensor), and triphenylmethane reductase (TMR) like proteins, atypical (a) SDRs
    COG0702
    Location:5206
    YbjT; Uncharacterized conserved protein YbjT, contains NAD(P)-binding and DUF2867 domains [General function prediction only]
  8. XM_011522567.3XP_011520869.1  nmrA-like family domain-containing protein 1 isoform X4

    See identical proteins and their annotated locations for XP_011520869.1

    Conserved Domains (2) summary
    cd08947
    Location:7240
    NmrA_TMR_like_SDR_a; NmrA (a transcriptional regulator), HSCARG (an NADPH sensor), and triphenylmethane reductase (TMR) like proteins, atypical (a) SDRs
    COG0702
    Location:5206
    YbjT; Uncharacterized conserved protein YbjT, contains NAD(P)-binding and DUF2867 domains [General function prediction only]
  9. XM_017023486.2XP_016878975.1  nmrA-like family domain-containing protein 1 isoform X2

  10. XM_017023487.2XP_016878976.1  nmrA-like family domain-containing protein 1 isoform X3

Reference GRCh38.p12 ALT_REF_LOCI_1

Genomic

  1. NT_187608.1 Reference GRCh38.p12 ALT_REF_LOCI_1

    Range
    164003..178660 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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