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RhoGAP1A Rho GTPase activating protein at 1A [ Drosophila melanogaster (fruit fly) ]

Gene ID: 5740235, updated on 6-May-2021

Summary

Official Symbol
RhoGAP1Aprovided by FlyBase
Official Full Name
Rho GTPase activating protein at 1Aprovided by FlyBase
Primary source
FLYBASE:FBgn0025836
Locus tag
Dmel_CG40494
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BCR; CG17617; CG17960; CG40453; CG40494; Dmel\CG40494; EG:23E12.2; EG:23E12.5; RhoGAP; rhoGAP1A
Old locus tag
Dmel_CG00000
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Genomic context

See RhoGAP1A in Genome Data Viewer
Location:
1A1-1A1; 1-0 cM
Exon count:
15
Annotation release Status Assembly Chr Location
Release 6.32 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (127449..140340)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (23836..36727)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR40469 Neighboring gene uncharacterized protein Neighboring gene mir-4915 stem loop Neighboring gene long non-coding RNA:CR45473 Neighboring gene uncharacterized protein Neighboring gene trynity

Genomic regions, transcripts, and products

General gene information

Homology

mobile_element

  • Loc: 130043-130141 mobile_element_type = transposon:INE-1{}4621
  • Loc: 130273-130671 mobile_element_type = transposon:INE-1{}4623
  • Loc: 135061-135784 mobile_element_type = transposon:INE-1{}4645

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
enables guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in Golgi organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell size IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of Rho protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
Rho GTPase activating protein at 1A
Names
CG40494-PA
CG40494-PB
CG40494-PC
CG40494-PD
CG40494-PE
CG40494-PF
RhoGAP1A-PA
RhoGAP1A-PB
RhoGAP1A-PC
RhoGAP1A-PD
RhoGAP1A-PE
RhoGAP1A-PF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    127449..140340
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001297796.1NP_001284725.1  Rho GTPase activating protein at 1A, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284725.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JC00
    Related
    FBpp0309061, FBtr0340054
    Conserved Domains (4) summary
    smart00325
    Location:675857
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd13368
    Location:8511037
    PH_BCR_arthropod; Breakpoint Cluster Region-related pleckstrin homology (PH) domain
    cl02570
    Location:12031398
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
    cl14603
    Location:10791187
    C2; C2 domain
  2. NM_001297795.1NP_001284724.1  Rho GTPase activating protein at 1A, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284724.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2J9V9
    Related
    FBpp0309060, FBtr0340053
    Conserved Domains (4) summary
    smart00325
    Location:673855
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd13368
    Location:8491035
    PH_BCR_arthropod; Breakpoint Cluster Region-related pleckstrin homology (PH) domain
    cl02570
    Location:12011396
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
    cl14603
    Location:10771185
    C2; C2 domain
  3. NM_001103385.2NP_001096855.1  Rho GTPase activating protein at 1A, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001096855.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q29QE1
    Related
    FBpp0111832, FBtr0112919
    Conserved Domains (4) summary
    smart00325
    Location:674856
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd13368
    Location:8501036
    PH_BCR_arthropod; Breakpoint Cluster Region-related pleckstrin homology (PH) domain
    cl02570
    Location:12021397
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
    cl14603
    Location:10781186
    C2; C2 domain
  4. NM_001103386.2NP_001096856.1  Rho GTPase activating protein at 1A, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001096856.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q29QE1
    Related
    FBpp0111833, FBtr0112920
    Conserved Domains (4) summary
    smart00325
    Location:674856
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd13368
    Location:8501036
    PH_BCR_arthropod; Breakpoint Cluster Region-related pleckstrin homology (PH) domain
    cl02570
    Location:12021397
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
    cl14603
    Location:10781186
    C2; C2 domain
  5. NM_001169155.1NP_001162626.1  Rho GTPase activating protein at 1A, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162626.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C1C560
    Related
    FBpp0291410, FBtr0302200
    Conserved Domains (3) summary
    smart00325
    Location:366548
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd13368
    Location:542728
    PH_BCR_arthropod; Breakpoint Cluster Region-related pleckstrin homology (PH) domain
    cl14603
    Location:770878
    C2; C2 domain
  6. NM_001297797.1NP_001284726.1  Rho GTPase activating protein at 1A, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284726.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C1C560
    Related
    FBpp0309062, FBtr0340055
    Conserved Domains (3) summary
    smart00325
    Location:366548
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd13368
    Location:542728
    PH_BCR_arthropod; Breakpoint Cluster Region-related pleckstrin homology (PH) domain
    cl14603
    Location:770878
    C2; C2 domain
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