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S100A14 S100 calcium binding protein A14 [ Homo sapiens (human) ]

Gene ID: 57402, updated on 6-Sep-2021

Summary

Official Symbol
S100A14provided by HGNC
Official Full Name
S100 calcium binding protein A14provided by HGNC
Primary source
HGNC:HGNC:18901
See related
Ensembl:ENSG00000189334 MIM:607986
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BCMP84; S100A15
Summary
This gene encodes a member of the S100 protein family which contains an EF-hand motif and binds calcium. The gene is located in a cluster of S100 genes on chromosome 1. Levels of the encoded protein have been found to be lower in cancerous tissue and associated with metastasis suggesting a tumor suppressor function (PMID: 19956863, 19351828). [provided by RefSeq, Dec 2011]
Expression
Biased expression in esophagus (RPKM 798.1), skin (RPKM 171.2) and 6 other tissues See more
Orthologs
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Genomic context

See S100A14 in Genome Data Viewer
Location:
1q21.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (153614255..153616917, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (153586731..153588801, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene S100 calcium binding protein A2 Neighboring gene S100 calcium binding protein A16 Neighboring gene S100 calcium binding protein A13 Neighboring gene S100 calcium binding protein A1 Neighboring gene chromatin target of PRMT1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium ion binding NAS
Non-traceable Author Statement
more info
PubMed 
enables calcium-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chemokine receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chemokine receptor binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein S100-A14
Names
S114
breast cancer membrane protein 84

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020672.3NP_065723.1  protein S100-A14

    See identical proteins and their annotated locations for NP_065723.1

    Status: VALIDATED

    Source sequence(s)
    AY007220, BG677973, BX470102
    Consensus CDS
    CCDS1046.1
    UniProtKB/Swiss-Prot
    Q9HCY8
    Related
    ENSP00000340463.2, ENST00000344616.4
    Conserved Domains (1) summary
    cd05022
    Location:16104
    S-100A13; S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, to which ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    153614255..153616917 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017001875.1XP_016857364.1  protein S100-A14 isoform X1

    UniProtKB/Swiss-Prot
    Q9HCY8
    Related
    ENSP00000357691.1, ENST00000368702.5
    Conserved Domains (1) summary
    cd05022
    Location:16104
    S-100A13; S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, to which ...
  2. XM_005245362.1XP_005245419.1  protein S100-A14 isoform X1

    See identical proteins and their annotated locations for XP_005245419.1

    UniProtKB/Swiss-Prot
    Q9HCY8
    Related
    ENSP00000357690.1, ENST00000368701.5
    Conserved Domains (1) summary
    cd05022
    Location:16104
    S-100A13; S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, to which ...
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