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PTGIS prostaglandin I2 synthase [ Homo sapiens (human) ]

Gene ID: 5740, updated on 4-Oct-2020

Summary

Official Symbol
PTGISprovided by HGNC
Official Full Name
prostaglandin I2 synthaseprovided by HGNC
Primary source
HGNC:HGNC:9603
See related
Ensembl:ENSG00000124212 MIM:601699
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CYP8; PGIS; PTGI; CYP8A1
Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. [provided by RefSeq, Jul 2008]
Expression
Broad expression in urinary bladder (RPKM 26.9), gall bladder (RPKM 23.0) and 16 other tissues See more
Orthologs

Genomic context

See PTGIS in Genome Data Viewer
Location:
20q13.13
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (49503874..49568137, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (48120411..48184707, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, C/D box 12 Neighboring gene ZNFX1 antisense RNA 1 Neighboring gene uncharacterized LOC105372649 Neighboring gene potassium voltage-gated channel subfamily B member 1 Neighboring gene uncharacterized LOC101927486 Neighboring gene uncharacterized LOC105372651 Neighboring gene beta-1,4-galactosyltransferase 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Biological insights from 108 schizophrenia-associated genetic loci.
GeneReviews: Not available
Essential hypertension
MedGen: C0085580 OMIM: 145500 GeneReviews: Not available
Compare labs

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126858, MGC126860

Gene Ontology Provided by GOA

Function Evidence Code Pubs
heme binding IDA
Inferred from Direct Assay
more info
PubMed 
iron ion binding IEA
Inferred from Electronic Annotation
more info
 
monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
 
prostaglandin-I synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
prostaglandin-I synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
NAD biosynthesis via nicotinamide riboside salvage pathway TAS
Traceable Author Statement
more info
 
apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to interleukin-1 IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to interleukin-6 IEP
Inferred from Expression Pattern
more info
PubMed 
cyclooxygenase pathway TAS
Traceable Author Statement
more info
 
decidualization IEA
Inferred from Electronic Annotation
more info
 
embryo implantation IEA
Inferred from Electronic Annotation
more info
 
icosanoid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
icosanoid metabolic process TAS
Traceable Author Statement
more info
 
negative regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of nitric oxide biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of execution phase of apoptosis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of peroxisome proliferator activated receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
prostaglandin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
prostaglandin biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
caveola IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
prostacyclin synthase
Names
cytochrome P450, family 8, subfamily A, polypeptide 1
hydroperoxy icosatetraenoate dehydratase
prostaglandin I2 (prostacyclin) synthase
NP_000952.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007940.1 RefSeqGene

    Range
    5034..69297
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000961.4NP_000952.1  prostacyclin synthase precursor

    See identical proteins and their annotated locations for NP_000952.1

    Status: REVIEWED

    Source sequence(s)
    AF297048, AL118525, D38145, D83402
    Consensus CDS
    CCDS13419.1
    UniProtKB/Swiss-Prot
    Q16647
    Related
    ENSP00000244043.3, ENST00000244043.5
    Conserved Domains (1) summary
    cl12078
    Location:27494
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    49503874..49568137 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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