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PTGIS prostaglandin I2 synthase [ Homo sapiens (human) ]

Gene ID: 5740, updated on 5-Jul-2025
Official Symbol
PTGISprovided by HGNC
Official Full Name
prostaglandin I2 synthaseprovided by HGNC
Primary source
HGNC:HGNC:9603
See related
Ensembl:ENSG00000124212 MIM:601699; AllianceGenome:HGNC:9603
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CYP8; PGIS; PTGI; CYP8A1
Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. [provided by RefSeq, Jul 2008]
Expression
Broad expression in urinary bladder (RPKM 26.9), gall bladder (RPKM 23.0) and 16 other tissues See more
Orthologs
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See PTGIS in Genome Data Viewer
Location:
20q13.13
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (49503874..49568137, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (51273490..51337709, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (48120411..48184674, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904925 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:47934991-47935572 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:47935573-47936154 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:47940265-47940766 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:47940767-47941266 Neighboring gene uncharacterized LOC105372649 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18061 Neighboring gene NANOG hESC enhancer GRCh37_chr20:47985158-47985711 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:47990213-47990475 Neighboring gene potassium voltage-gated channel subfamily B member 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:48040793-48041316 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:48041317-48041840 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:48063137-48063648 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:48063649-48064158 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:48064159-48064670 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12997 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12998 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:48121719-48122220 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18062 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:48158843-48159119 Neighboring gene uncharacterized LOC101927486 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:48184974-48185590 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:48185591-48186205 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:48196657-48197231 Neighboring gene uncharacterized LOC105372651 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:48212298-48212798 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:48227493-48227993 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13000 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18063 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18064 Neighboring gene uncharacterized LOC124904926 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18065 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18066 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:48247798-48248480

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Associated conditions

Description Tests
Essential hypertension, genetic
MedGen: CN305331 OMIM: 145500 GeneReviews: Not available
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EBI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
EBI GWAS Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • MGC126858, MGC126860

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables heme binding IDA
Inferred from Direct Assay
more info
PubMed 
enables heme binding IEA
Inferred from Electronic Annotation
more info
 
enables hydroperoxy icosatetraenoate dehydratase activity IEA
Inferred from Electronic Annotation
more info
 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
 
enables prostaglandin-I synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables prostaglandin-I synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables prostaglandin-I synthase activity IEA
Inferred from Electronic Annotation
more info
 
enables prostaglandin-I synthase activity TAS
Traceable Author Statement
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in NAD+ biosynthetic process via the salvage pathway TAS
Traceable Author Statement
more info
 
involved_in apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to interleukin-1 IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to interleukin-6 IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within decidualization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within embryo implantation IEA
Inferred from Electronic Annotation
more info
 
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in icosanoid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in icosanoid metabolic process TAS
Traceable Author Statement
more info
 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of nitric oxide biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of execution phase of apoptosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of peroxisome proliferator activated receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in prostaglandin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in prostaglandin biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in prostaglandin biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in prostaglandin metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in prostanoid biosynthetic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
located_in caveola IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
prostacyclin synthase
Names
cytochrome P450, family 8, subfamily A, polypeptide 1
hydroperoxy icosatetraenoate dehydratase
prostaglandin I2 (prostacyclin) synthase
NP_000952.1
XP_047296281.1
XP_054179732.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007940.1 RefSeqGene

    Range
    5034..69297
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000961.4NP_000952.1  prostacyclin synthase

    See identical proteins and their annotated locations for NP_000952.1

    Status: REVIEWED

    Source sequence(s)
    AF297048, AL118525, D38145, D83402
    Consensus CDS
    CCDS13419.1
    UniProtKB/Swiss-Prot
    Q16647, Q3MII8, Q9HAX2, Q9HAX3, Q9HAX4
    UniProtKB/TrEMBL
    Q6LEN2
    Related
    ENSP00000244043.3, ENST00000244043.5
    Conserved Domains (1) summary
    cl12078
    Location:27494
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    49503874..49568137 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047440325.1XP_047296281.1  prostacyclin synthase isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    51273490..51337709 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054323757.1XP_054179732.1  prostacyclin synthase isoform X1