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CLK4 CDC like kinase 4 [ Homo sapiens (human) ]

Gene ID: 57396, updated on 25-Nov-2021


Official Symbol
CLK4provided by HGNC
Official Full Name
CDC like kinase 4provided by HGNC
Primary source
See related
Ensembl:ENSG00000113240 MIM:607969
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
The protein encoded by this gene belongs to the CDC2-like protein kinase (CLK) family. This protein kinase can interact with and phosphorylate the serine- and arginine-rich (SR) proteins, which are known to play an important role in the formation of spliceosomes, and thus may be involved in the regulation of alternative splicing. Studies in the Israeli sand rat Psammomys obesus suggested that the ubiquitin-like 5 (UBL5/BEACON), a highly conserved ubiquitin-like protein, may interact with and regulate the activity of this kinase. Multiple alternatively spliced transcript variants have been observed, but the full-length natures of which have not yet been determined. [provided by RefSeq, Jul 2008]
Ubiquitous expression in lymph node (RPKM 15.9), bone marrow (RPKM 13.8) and 25 other tissues See more
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Genomic context

See CLK4 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (178602664..178627050, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (178029665..178054051, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene collagen type XXIII alpha 1 chain Neighboring gene RNA, 7SL, cytoplasmic 646, pseudogene Neighboring gene uncharacterized LOC105377756 Neighboring gene RN7SK pseudogene 70 Neighboring gene vomeronasal 2 receptor 2 pseudogene Neighboring gene Myb/SANT DNA binding domain containing 5

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


Pathways from PubChem


Products Interactant Other Gene Complex Source Pubs Description

General gene information



Clone Names

  • DKFZp686A20267

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
enables protein binding IPI
Inferred from Physical Interaction
more info
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
Process Evidence Code Pubs
involved_in peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
involved_in protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
involved_in regulation of RNA splicing IMP
Inferred from Mutant Phenotype
more info
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info

General protein information

Preferred Names
dual specificity protein kinase CLK4
protein serine threonine kinase Clk4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020666.3NP_065717.1  dual specificity protein kinase CLK4

    See identical proteins and their annotated locations for NP_065717.1

    Status: REVIEWED

    Source sequence(s)
    BC015942, BC063116, CB127989
    Consensus CDS
    ENSP00000316948.4, ENST00000316308.9
    Conserved Domains (1) summary
    PKc_CLK1_4; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases 1 and 4

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly


  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    178602664..178627050 complement
    GenBank, FASTA, Sequence Viewer (Graphics)
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