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PTGIR prostaglandin I2 receptor [ Homo sapiens (human) ]

Gene ID: 5739, updated on 13-Mar-2020

Summary

Official Symbol
PTGIRprovided by HGNC
Official Full Name
prostaglandin I2 receptorprovided by HGNC
Primary source
HGNC:HGNC:9602
See related
Ensembl:ENSG00000160013 MIM:600022
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IP; PRIPR
Summary
The protein encoded by this gene is a member of the G-protein coupled receptor family 1 and has been shown to be a receptor for prostacyclin. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and inhibition of platelet aggregation through binding to this receptor. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 50.8), placenta (RPKM 17.2) and 24 other tissues See more
Orthologs

Genomic context

See PTGIR in Genome Data Viewer
Location:
19q13.32
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (46610040..46625097, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (47114585..47128375, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene PPP5 tetratricopeptide repeat domain containing 1 Neighboring gene paraneoplastic antigen-like protein 8B Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 38 Neighboring gene calmodulin 3 Neighboring gene G protein subunit gamma 8 Neighboring gene dishevelled binding antagonist of beta catenin 3 Neighboring gene DACT3 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC102830

Gene Ontology Provided by GOA

Function Evidence Code Pubs
guanyl-nucleotide exchange factor activity TAS
Traceable Author Statement
more info
 
prostacyclin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
prostacyclin receptor
Names
PGI receptor
PGI2 receptor
prostaglandin I2 (prostacyclin) receptor (IP)
prostanoid IP receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000960.4NP_000951.1  prostacyclin receptor

    See identical proteins and their annotated locations for NP_000951.1

    Status: REVIEWED

    Source sequence(s)
    BQ185457, D25418, DA652875
    Consensus CDS
    CCDS12686.1
    UniProtKB/Swiss-Prot
    P43119
    Related
    ENSP00000291294.1, ENST00000291294.7
    Conserved Domains (2) summary
    cd14964
    Location:1640
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:14304
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    46610040..46625097 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005259095.4XP_005259152.1  prostacyclin receptor isoform X2

    Conserved Domains (1) summary
    cl21561
    Location:27221
    7tm_4; Olfactory receptor
  2. XM_005259093.3XP_005259150.1  prostacyclin receptor isoform X1

    Conserved Domains (1) summary
    cl21561
    Location:27221
    7tm_4; Olfactory receptor

RNA

  1. XR_430206.3 RNA Sequence

  2. XR_935844.2 RNA Sequence

  3. XR_243945.3 RNA Sequence

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