Format

Send to:

Choose Destination

RHOJ ras homolog family member J [ Homo sapiens (human) ]

Gene ID: 57381, updated on 7-Dec-2018

Summary

Official Symbol
RHOJprovided by HGNC
Official Full Name
ras homolog family member Jprovided by HGNC
Primary source
HGNC:HGNC:688
See related
Ensembl:ENSG00000126785 MIM:607653
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TCL; ARHJ; TC10B; RASL7B
Summary
This gene encodes one of the many small GTP-binding proteins in the Rho family shown to be associated with focal adhesions in endothelial cells (PMID: 21148427, 22103495). The encoded protein is activated by vascular endothelial growth factor and may regulate angiogenesis. [provided by RefSeq, Dec 2011]
Expression
Ubiquitous expression in gall bladder (RPKM 9.9), lung (RPKM 9.2) and 23 other tissues See more
Orthologs

Genomic context

See RHOJ in Genome Data Viewer
Location:
14q23.2
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (63204384..63293512)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (63671080..63760230)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370531 Neighboring gene poly(ADP-ribose) polymerase 1 pseudogene 2 Neighboring gene uncharacterized LOC105370530 Neighboring gene glycoprotein hormone beta 5 Neighboring gene protein phosphatase 2 regulatory subunit B'epsilon Neighboring gene loricrin-like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Insulin Signaling, organism-specific biosystem (from WikiPathways)
    Insulin Signaling, organism-specific biosystemInsulin signaling influences energy metabolism as well as growth. The presence of insulin signals the fed state, and this signal is passed via the AKT branch, which leads to the uptake of glucose fro...
  • Rho GTPase cycle, organism-specific biosystem (from REACTOME)
    Rho GTPase cycle, organism-specific biosystemThe cycling of Rho GTPases is tightly controlled by three classes of protein. These are (1) guanine nucleotide dissociation inhibitors or GDIs, which maintain Rho proteins in an inactive state in the...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
    Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14445, MGC34777

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTP binding IDA
Inferred from Direct Assay
more info
PubMed 
GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
GTPase activity NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
cell projection assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
establishment or maintenance of cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell migration involved in sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
regulation of sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
retina vasculature morphogenesis in camera-type eye IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
rho-related GTP-binding protein RhoJ
Names
RAS-like, family 7, member B
TC10-like Rho GTPase
ras homolog gene family, member J
ras-like protein family member 7B
tc10-like GTP-binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020663.5NP_065714.1  rho-related GTP-binding protein RhoJ precursor

    See identical proteins and their annotated locations for NP_065714.1

    Status: VALIDATED

    Source sequence(s)
    AF087862, AK027351, AL049871, BM555132
    Consensus CDS
    CCDS9757.1
    UniProtKB/Swiss-Prot
    Q9H4E5
    UniProtKB/TrEMBL
    A0A024R692, Q7Z513
    Related
    ENSP00000316729.3, ENST00000316754.7
    Conserved Domains (1) summary
    cl21455
    Location:22195
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

    Range
    63204384..63293512
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536993.3XP_011535295.1  rho-related GTP-binding protein RhoJ isoform X2

    Conserved Domains (2) summary
    smart00174
    Location:24142
    RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
    cl21455
    Location:22140
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. XM_006720214.4XP_006720277.1  rho-related GTP-binding protein RhoJ isoform X1

    See identical proteins and their annotated locations for XP_006720277.1

    Related
    ENSP00000451643.1, ENST00000555125.1
    Conserved Domains (2) summary
    smart00174
    Location:24171
    RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
    cl21455
    Location:22167
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RNA

  1. XR_245709.4 RNA Sequence

  2. XR_245708.4 RNA Sequence

Support Center