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MRS2 magnesium transporter MRS2 [ Homo sapiens (human) ]

Gene ID: 57380, updated on 25-Nov-2021

Summary

Official Symbol
MRS2provided by HGNC
Official Full Name
magnesium transporter MRS2provided by HGNC
Primary source
HGNC:HGNC:13785
See related
Ensembl:ENSG00000124532 MIM:619307
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HPT; MRS2L
Expression
Ubiquitous expression in heart (RPKM 8.7), thyroid (RPKM 7.9) and 25 other tissues See more
Orthologs
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Genomic context

See MRS2 in Genome Data Viewer
Location:
6p22.3
Exon count:
12
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (24402936..24426190)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (24403164..24426418)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene doublecortin domain containing 2 Neighboring gene RNA, U6 small nuclear 391, pseudogene Neighboring gene kidney associated antigen 1 Neighboring gene glycosylphosphatidylinositol specific phospholipase D1 Neighboring gene aldehyde dehydrogenase 5 family member A1 Neighboring gene KIAA0319 Neighboring gene keratin 8 pseudogene 43

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of MRS2 magnesium homeostasis factor homolog by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev is identified to have a physical interaction with magnesium homeostasis factor homolog (MRS2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC78523

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in magnesium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitochondrial magnesium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitochondrial magnesium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transmembrane transport TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
magnesium transporter MRS2 homolog, mitochondrial
Names
MRS2, magnesium transporter
MRS2-like protein
MRS2-like, magnesium homeostasis factor
putative magnesium transporter

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286264.2NP_001273193.1  magnesium transporter MRS2 homolog, mitochondrial isoform a

    See identical proteins and their annotated locations for NP_001273193.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AA836333, AF293076, AK298849, AL359713, BM829320
    Consensus CDS
    CCDS69055.1
    UniProtKB/Swiss-Prot
    Q9HD23
    Related
    ENSP00000399585.2, ENST00000443868.6
    Conserved Domains (1) summary
    cd12823
    Location:88402
    Mrs2_Mfm1p-like; Saccharomyces cerevisiae inner mitochondrial membrane Mg2+ transporters Mfm1p and Mrs2p-like family
  2. NM_001286265.2NP_001273194.1  magnesium transporter MRS2 homolog, mitochondrial isoform c

    See identical proteins and their annotated locations for NP_001273194.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon and uses an alternate splice site, which results in an alternate in-frame segment in the 5' coding region, and it contains an alternate 3' terminal exon and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (c) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AA828962, BC069009, BM829320
    Consensus CDS
    CCDS75408.1
    UniProtKB/Swiss-Prot
    Q9HD23
    Related
    ENSP00000367604.1, ENST00000378353.5
    Conserved Domains (1) summary
    cd12823
    Location:88399
    Mrs2_Mfm1p-like; Saccharomyces cerevisiae inner mitochondrial membrane Mg2+ transporters Mfm1p and Mrs2p-like family
  3. NM_001286266.2NP_001273195.1  magnesium transporter MRS2 homolog, mitochondrial isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks three exons and uses an alternate splice site, which results in the loss of an in-frame segment in the 5' coding region, compared to variant 1. The encoded isoform (d) is shorter than isoform a.
    Source sequence(s)
    AA836333, AF293076, AK299825, AL359713, BM829320, DC305123
    Consensus CDS
    CCDS69056.1
    UniProtKB/Swiss-Prot
    Q9HD23
    UniProtKB/TrEMBL
    A0A0A0MQX2, B4DSN2
    Related
    ENSP00000274747.8, ENST00000274747.11
    Conserved Domains (1) summary
    cd12823
    Location:89349
    Mrs2_Mfm1p-like; Saccharomyces cerevisiae inner mitochondrial membrane Mg2+ transporters Mfm1p and Mrs2p-like family
  4. NM_020662.4NP_065713.1  magnesium transporter MRS2 homolog, mitochondrial isoform b precursor

    See identical proteins and their annotated locations for NP_065713.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon and uses an alternate splice site, which results in an alternate in-frame segment in the 5' coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AA836333, AF293076, AK291058, AL359713, BM829320
    Consensus CDS
    CCDS4552.1
    UniProtKB/Swiss-Prot
    Q9HD23
    Related
    ENSP00000367637.3, ENST00000378386.8
    Conserved Domains (1) summary
    cd12823
    Location:88399
    Mrs2_Mfm1p-like; Saccharomyces cerevisiae inner mitochondrial membrane Mg2+ transporters Mfm1p and Mrs2p-like family

RNA

  1. NR_104423.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks two exons and uses two alternate splice sites in the 5' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA836333, AF293076, AK297418, AL359713

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    24402936..24426190
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005249242.2XP_005249299.1  magnesium transporter MRS2 homolog, mitochondrial isoform X1

    Conserved Domains (1) summary
    cd12823
    Location:88369
    Mrs2_Mfm1p-like; Saccharomyces cerevisiae inner mitochondrial membrane Mg2+ transporters Mfm1p and Mrs2p-like family

RNA

  1. XR_001743533.2 RNA Sequence

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