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As3mt arsenite methyltransferase [ Mus musculus (house mouse) ]

Gene ID: 57344, updated on 12-May-2024

Summary

Official Symbol
As3mtprovided by MGI
Official Full Name
arsenite methyltransferaseprovided by MGI
Primary source
MGI:MGI:1929882
See related
Ensembl:ENSMUSG00000003559 AllianceGenome:MGI:1929882
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cyt19; 2310045H08Rik
Summary
Predicted to enable arsenite methyltransferase activity and methylarsonite methyltransferase activity. Predicted to be involved in arsonoacetate metabolic process; methylation; and toxin metabolic process. Predicted to act upstream of or within response to arsenic-containing substance. Located in mitochondrion. Orthologous to human AS3MT (arsenite methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 19.2), heart adult (RPKM 12.7) and 28 other tissues See more
Orthologs
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Genomic context

See As3mt in Genome Data Viewer
Location:
19 C3; 19 38.97 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (46695124..46729538)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (46707157..46741099)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41857 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene BLOC-1 related complex subunit 7 Neighboring gene STARR-positive B cell enhancer ABC_E8753 Neighboring gene cyclin M2 Neighboring gene STARR-seq mESC enhancer starr_46325 Neighboring gene STARR-seq mESC enhancer starr_46328 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:46962419-46962620 Neighboring gene 5'-nucleotidase, cytosolic II Neighboring gene DBF4 homolog pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 
  • Targeted (1)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables arsenite methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables arsenite methyltransferase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in arsonoacetate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in arsonoacetate metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in methylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to arsenic-containing substance ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in toxin metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in toxin metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 

General protein information

Preferred Names
arsenite methyltransferase
Names
S-adenosyl-L-methionine:arsenic(III) methyltransferase
S-adenosylmethionine:arsenic (III) methyltransferase
arsenic (+3 oxidation state) methyltransferase
methylarsonite methyltransferase
methyltransferase Cyt19
NP_065602.2
XP_006527298.1
XP_011245604.1
XP_030106865.1
XP_036017540.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020577.3NP_065602.2  arsenite methyltransferase

    See identical proteins and their annotated locations for NP_065602.2

    Status: VALIDATED

    Source sequence(s)
    AC161865
    Consensus CDS
    CCDS50458.1
    UniProtKB/Swiss-Prot
    A6H5W4, E9QLU6, Q91WU5, Q9QZT1
    Related
    ENSMUSP00000003655.8, ENSMUST00000003655.9
    Conserved Domains (1) summary
    pfam13847
    Location:71183
    Methyltransf_31; Methyltransferase domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    46695124..46729538
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527235.3XP_006527298.1  arsenite methyltransferase isoform X1

    Conserved Domains (1) summary
    PRK11873
    Location:61266
    arsM; arsenite methyltransferase
  2. XM_030251005.2XP_030106865.1  arsenite methyltransferase isoform X2

    Conserved Domains (1) summary
    PRK11873
    Location:996
    arsM; arsenite methyltransferase
  3. XM_011247302.4XP_011245604.1  arsenite methyltransferase isoform X2

    Conserved Domains (1) summary
    PRK11873
    Location:996
    arsM; arsenite methyltransferase
  4. XM_036161647.1XP_036017540.1  arsenite methyltransferase isoform X2

    Conserved Domains (1) summary
    PRK11873
    Location:996
    arsM; arsenite methyltransferase

RNA

  1. XR_003952795.2 RNA Sequence