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ZNF304 zinc finger protein 304 [ Homo sapiens (human) ]

Gene ID: 57343, updated on 12-Oct-2019

Summary

Official Symbol
ZNF304provided by HGNC
Official Full Name
zinc finger protein 304provided by HGNC
Primary source
HGNC:HGNC:13505
See related
Ensembl:ENSG00000131845 MIM:613840
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the Krueppel C2H2-type zinc-finger family of proteins. The encoded protein functions as a transcriptional repressor that recruits a corepressor complex to stimulate promoter hypermethylation and transcriptional silencing of target genes. Expression of this gene is upregulated in colorectal, ovarian and breast cancer, and this gene may promote cancer cell survival, growth and invasion. [provided by RefSeq, Jul 2016]
Expression
Ubiquitous expression in thyroid (RPKM 4.2), spleen (RPKM 3.4) and 25 other tissues See more
Orthologs

Genomic context

See ZNF304 in Genome Data Viewer
Location:
19q13.43
Exon count:
5
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (57351253..57359898)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (57862645..57871266)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene PPPDE peptidase domain containing 1 pseudogene Neighboring gene zinc finger protein 543 Neighboring gene trafficking protein particle complex 2B Neighboring gene zinc finger protein 547 Neighboring gene zinc finger protein 548

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from BioSystems

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC129703, MGC129704

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
promoter-specific chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger protein 304
Names
KRAB-containing zinc finger protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051201.1 RefSeqGene

    Range
    5022..13646
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001290318.1NP_001277247.1  zinc finger protein 304 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC005261, BC111532, BP315423
    Consensus CDS
    CCDS77365.1
    UniProtKB/TrEMBL
    E7EQD3, Q2T9G7
    Related
    ENSP00000401642.2, ENST00000443917.6
    Conserved Domains (5) summary
    smart00349
    Location:1473
    KRAB; krueppel associated box
    COG5048
    Location:325680
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:384404
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:1453
    KRAB; KRAB box
    pfam13465
    Location:396421
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001290319.1NP_001277248.1  zinc finger protein 304 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, initiates translation at a downstream start codon and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 3, which is shorter than isoform 1.
    Source sequence(s)
    AC005261, BC111531, BP315423
    Consensus CDS
    CCDS74462.1
    UniProtKB/TrEMBL
    M0QZ59, Q2T9G8
    Related
    ENSP00000470319.1, ENST00000598744.1
    Conserved Domains (3) summary
    COG5048
    Location:236591
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:295315
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:307332
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001329456.1NP_001316385.1  zinc finger protein 304 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses a downstream translation start site compared to variant 1. The encoded isoform (4) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AC005261
  4. NM_020657.3NP_065708.2  zinc finger protein 304 isoform 2

    See identical proteins and their annotated locations for NP_065708.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AC005261, BC111532, BP315423
    Consensus CDS
    CCDS12950.1
    UniProtKB/Swiss-Prot
    Q9HCX3
    UniProtKB/TrEMBL
    Q2T9G7
    Related
    ENSP00000282286.4, ENST00000282286.5
    Conserved Domains (5) summary
    smart00349
    Location:1455
    KRAB; krueppel associated box
    COG5048
    Location:278633
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:337357
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:1453
    KRAB; KRAB box
    pfam13465
    Location:349374
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    57351253..57359898
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527145.2XP_011525447.1  zinc finger protein 304 isoform X1

    See identical proteins and their annotated locations for XP_011525447.1

    Conserved Domains (3) summary
    COG5048
    Location:283638
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:342362
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:354379
    zf-H2C2_2; Zinc-finger double domain
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