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SENP7 SUMO specific peptidase 7 [ Homo sapiens (human) ]

Gene ID: 57337, updated on 12-Oct-2019

Summary

Official Symbol
SENP7provided by HGNC
Official Full Name
SUMO specific peptidase 7provided by HGNC
Primary source
HGNC:HGNC:30402
See related
Ensembl:ENSG00000138468 MIM:612846
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for many cellular processes. SUMO-specific proteases, such as SENP7, process SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed 18799455]).[supplied by OMIM, Jun 2009]
Expression
Ubiquitous expression in endometrium (RPKM 9.0), lymph node (RPKM 7.6) and 25 other tissues See more
Orthologs

Genomic context

See SENP7 in Genome Data Viewer
Location:
3q12.3
Exon count:
27
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (101324205..101513883, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (101043049..101232085, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ACTR3 pseudogene 3 Neighboring gene interphotoreceptor matrix proteoglycan 2 Neighboring gene zinc finger protein 90 pseudogene 1 Neighboring gene family with sequence similarity 136 member A pseudogene Neighboring gene basic transcription factor 3 pseudogene 16 Neighboring gene family with sequence similarity 172 member B, pseudogene Neighboring gene tRNA methyltransferase 10C, mitochondrial RNase P subunit

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1707, MGC157730

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SUMO-specific endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
protein desumoylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
sentrin-specific protease 7
Names
SUMO-1-specific protease 2
SUMO1/sentrin specific peptidase 7
sentrin/SUMO-specific protease SENP7
NP_001070671.1
NP_001269730.1
NP_001269731.1
NP_001269732.1
NP_001269733.1
NP_065705.3
XP_005247719.1
XP_011511340.1
XP_011511341.1
XP_011511342.1
XP_011511343.1
XP_011511344.1
XP_011511347.1
XP_016862413.1
XP_016862414.1
XP_016862415.1
XP_016862416.1
XP_016862417.1
XP_016862418.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077203.3NP_001070671.1  sentrin-specific protease 7 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2, also known as SENP7S) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AI858732, AL136599, BC129988
    Consensus CDS
    CCDS43121.1
    UniProtKB/Swiss-Prot
    Q9BQF6
    UniProtKB/TrEMBL
    J3QT09
    Related
    ENSP00000377654.2, ENST00000394094.6
    Conserved Domains (1) summary
    cl23802
    Location:709946
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
  2. NM_001282801.2NP_001269730.1  sentrin-specific protease 7 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
    Source sequence(s)
    AI858732, AL136599, BC129988
    Consensus CDS
    CCDS63706.1
    UniProtKB/Swiss-Prot
    Q9BQF6
    Related
    ENSP00000313624.7, ENST00000314261.11
    Conserved Domains (1) summary
    cl23802
    Location:708945
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
  3. NM_001282802.2NP_001269731.1  sentrin-specific protease 7 isoform 4

    See identical proteins and their annotated locations for NP_001269731.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in its 5' UTR, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AI858732, AL136599, BC129988
    Consensus CDS
    CCDS63705.1
    UniProtKB/Swiss-Prot
    Q9BQF6
    Related
    ENSP00000342159.3, ENST00000348610.3
    Conserved Domains (1) summary
    cl23802
    Location:741978
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
  4. NM_001282803.2NP_001269732.1  sentrin-specific protease 7 isoform 5

    See identical proteins and their annotated locations for NP_001269732.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in its 5' UTR, initiates translation at a downstream start codon, and lacks two in-frame exons in the central coding region, compared to variant 1. The encoded isoform (5) is shorter, compared to isoform 1.
    Source sequence(s)
    AI858732, AL136599, BC129988
    Consensus CDS
    CCDS63704.1
    UniProtKB/Swiss-Prot
    Q9BQF6
    Related
    ENSP00000377651.1, ENST00000394091.5
    Conserved Domains (1) summary
    cl23802
    Location:610847
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
  5. NM_001282804.1NP_001269733.1  sentrin-specific protease 7 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in its 5' UTR, initiates translation at a downstream start codon, lacks several exons, and its 3'-terminal exon extends past a splice site that is used in variant 1. The encoded isoform (6) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AA651903, AL136599, BC129988, BU619557
    UniProtKB/Swiss-Prot
    Q9BQF6
  6. NM_020654.5NP_065705.3  sentrin-specific protease 7 isoform 1

    See identical proteins and their annotated locations for NP_065705.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, also known as SENP7L) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AI858732, AL136599, BC129988
    Consensus CDS
    CCDS2941.2
    UniProtKB/Swiss-Prot
    Q9BQF6
    Related
    ENSP00000377655.2, ENST00000394095.7
    Conserved Domains (1) summary
    cl23802
    Location:7741011
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    101324205..101513883 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011513039.3XP_011511341.1  sentrin-specific protease 7 isoform X2

    Conserved Domains (1) summary
    cl23802
    Location:742979
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
  2. XM_005247662.5XP_005247719.1  sentrin-specific protease 7 isoform X9

    Conserved Domains (1) summary
    cl23802
    Location:643880
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
  3. XM_011513042.3XP_011511344.1  sentrin-specific protease 7 isoform X8

    Conserved Domains (1) summary
    cl23802
    Location:644881
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
  4. XM_011513041.3XP_011511343.1  sentrin-specific protease 7 isoform X5

    Conserved Domains (1) summary
    cl23802
    Location:709946
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
  5. XM_011513040.3XP_011511342.1  sentrin-specific protease 7 isoform X4

    Conserved Domains (1) summary
    cl23802
    Location:710947
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
  6. XM_011513038.3XP_011511340.1  sentrin-specific protease 7 isoform X1

    Conserved Domains (1) summary
    cl23802
    Location:7751012
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
  7. XM_017006927.1XP_016862416.1  sentrin-specific protease 7 isoform X7

  8. XM_017006926.1XP_016862415.1  sentrin-specific protease 7 isoform X6

  9. XM_017006925.1XP_016862414.1  sentrin-specific protease 7 isoform X3

    UniProtKB/Swiss-Prot
    Q9BQF6
    Conserved Domains (1) summary
    cl23802
    Location:741978
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
  10. XM_017006924.1XP_016862413.1  sentrin-specific protease 7 isoform X2

    Conserved Domains (1) summary
    cl23802
    Location:742979
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
  11. XM_017006928.2XP_016862417.1  sentrin-specific protease 7 isoform X10

    Conserved Domains (1) summary
    cl23802
    Location:775816
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
  12. XM_011513045.3XP_011511347.1  sentrin-specific protease 7 isoform X11

  13. XM_017006929.2XP_016862418.1  sentrin-specific protease 7 isoform X12

RNA

  1. XR_001740218.2 RNA Sequence

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