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ZNF287 zinc finger protein 287 [ Homo sapiens (human) ]

Gene ID: 57336, updated on 13-Mar-2020

Summary

Official Symbol
ZNF287provided by HGNC
Official Full Name
zinc finger protein 287provided by HGNC
Primary source
HGNC:HGNC:13502
See related
Ensembl:ENSG00000141040
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZSCAN45; ZKSCAN13
Summary
This gene encodes a member of the krueppel family of zinc finger proteins, suggesting a role as a transcription factor. Its specific function has not been determined. This gene is located near the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 1.8), thyroid (RPKM 1.4) and 23 other tissues See more
Orthologs

Genomic context

See ZNF287 in Genome Data Viewer
Location:
17p11.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (16546689..16569212, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (16453626..16472520, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, C/D box 65 Neighboring gene leucine rich repeat containing 75A Neighboring gene small nucleolar RNA host gene 29 Neighboring gene uncharacterized LOC105371554 Neighboring gene serine and arginine rich splicing factor 6 pseudogene Neighboring gene zinc finger protein 624

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126536, MGC141923

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
positive regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
regulation of cytokine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger protein 287
Names
zinc finger protein with KRAB and SCAN domains 13

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051652.1 RefSeqGene

    Range
    5009..27259
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001346167.1NP_001333096.1  zinc finger protein 287 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1-4 all encode the same isoform (a).
    Source sequence(s)
    AC127540
    Consensus CDS
    CCDS11179.2
  2. NM_001346168.1NP_001333097.1  zinc finger protein 287 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same isoform (a).
    Source sequence(s)
    AC127540
    Consensus CDS
    CCDS11179.2
  3. NM_001346169.1NP_001333098.1  zinc finger protein 287 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same isoform (a).
    Source sequence(s)
    AC127540
    Consensus CDS
    CCDS11179.2
    Related
    ENSP00000379168.1, ENST00000395824.5
  4. NM_001346170.1NP_001333099.1  zinc finger protein 287 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC127540
  5. NM_001346171.1NP_001333100.1  zinc finger protein 287 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AC127540
  6. NM_020653.4NP_065704.2  zinc finger protein 287 isoform a

    See identical proteins and their annotated locations for NP_065704.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same isoform (a).
    Source sequence(s)
    AC127540, BC057791, DA103127
    Consensus CDS
    CCDS11179.2
    UniProtKB/TrEMBL
    Q6PEZ3
    Related
    ENSP00000379169.3, ENST00000395825.4
    Conserved Domains (7) summary
    smart00349
    Location:170227
    KRAB; krueppel associated box
    COG5048
    Location:366718
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:426446
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:592614
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:170209
    KRAB; KRAB box
    pfam02023
    Location:46133
    SCAN; SCAN domain
    pfam13465
    Location:662687
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    16546689..16569212 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011523968.2XP_011522270.1  zinc finger protein 287 isoform X1

    See identical proteins and their annotated locations for XP_011522270.1

    Conserved Domains (7) summary
    smart00349
    Location:170227
    KRAB; krueppel associated box
    COG5048
    Location:366718
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:426446
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:592614
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:170209
    KRAB; KRAB box
    pfam02023
    Location:46133
    SCAN; SCAN domain
    pfam13465
    Location:662687
    zf-H2C2_2; Zinc-finger double domain
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