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CBX8 chromobox 8 [ Homo sapiens (human) ]

Gene ID: 57332, updated on 21-Mar-2023

Summary

Official Symbol
CBX8provided by HGNC
Official Full Name
chromobox 8provided by HGNC
Primary source
HGNC:HGNC:15962
See related
Ensembl:ENSG00000141570 MIM:617354; AllianceGenome:HGNC:15962
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PC3; RC1
Summary
Enables methylated histone binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in chromatin and nucleoplasm. Part of PRC1 complex. Biomarker of esophagus squamous cell carcinoma and glioblastoma. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 4.1), placenta (RPKM 2.1) and 25 other tissues See more
Orthologs
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Genomic context

See CBX8 in Genome Data Viewer
Location:
17q25.3
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (79792132..79797077, complement)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (80689957..80694902, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (77765931..77770876, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904070 Neighboring gene chromobox 2 Neighboring gene Sharpr-MPRA regulatory region 5922 Neighboring gene uncharacterized LOC124904071

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables methylated histone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables single-stranded RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin-protein transferase activator activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in histone ubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of PRC1 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of PRC1 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of PcG protein complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in chromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in heterochromatin IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
chromobox protein homolog 8
Names
Pc class 3 homolog
chromobox homolog 8 (Pc class homolog, Drosophila)
polycomb 3
rectachrome 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020649.3NP_065700.1  chromobox protein homolog 8

    See identical proteins and their annotated locations for NP_065700.1

    Status: VALIDATED

    Source sequence(s)
    AC100791, AC105337, AF174482, AK074560
    Consensus CDS
    CCDS11765.1
    UniProtKB/Swiss-Prot
    Q9HC52, Q9NR07
    Related
    ENSP00000269385.4, ENST00000269385.9
    Conserved Domains (1) summary
    smart00298
    Location:1062
    CHROMO; Chromatin organization modifier domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    79792132..79797077 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    80689957..80694902 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)