U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Terf2ip telomeric repeat binding factor 2, interacting protein [ Mus musculus (house mouse) ]

Gene ID: 57321, updated on 10-Jun-2024

Summary

Official Symbol
Terf2ipprovided by MGI
Official Full Name
telomeric repeat binding factor 2, interacting proteinprovided by MGI
Primary source
MGI:MGI:1929871
See related
Ensembl:ENSMUSG00000033430 AllianceGenome:MGI:1929871
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rap1
Summary
Enables telomeric DNA binding activity. Involved in positive regulation of I-kappaB kinase/NF-kappaB signaling; regulation of nucleobase-containing compound metabolic process; and telomere maintenance via telomere lengthening. Located in chromosome, telomeric region; cytoplasm; and nucleus. Is expressed in embryo. Orthologous to human TERF2IP (TERF2 interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 11.5), CNS E14 (RPKM 9.4) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Terf2ip in Genome Data Viewer
Location:
8 E1; 8 58.29 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (112737991..112747160)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (112011359..112020528)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene adenosine deaminase, tRNA-specific 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:114500469-114500652 Neighboring gene STARR-positive B cell enhancer ABC_E6687 Neighboring gene STARR-positive B cell enhancer ABC_E1376 Neighboring gene lysyl-tRNA synthetase 1 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene predicted gene 9564 Neighboring gene predicted gene, 36671 Neighboring gene predicted gene, 22827

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G-rich strand telomeric DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables telomeric DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables telomeric DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA recombination at telomere IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of telomere maintenance ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of non-canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of telomere maintenance NAS
Non-traceable Author Statement
more info
PubMed 
NOT involved_in protection from non-homologous end joining at telomere IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of telomere maintenance ISO
Inferred from Sequence Orthology
more info
 
involved_in telomere capping ISO
Inferred from Sequence Orthology
more info
 
involved_in telomere maintenance ISO
Inferred from Sequence Orthology
more info
 
involved_in telomere maintenance via telomere lengthening IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in telomere maintenance via telomere lengthening IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT involved_in telomeric loop formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, telomeric region IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome, telomeric region IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in male germ cell nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
part_of nuclear telomere cap complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of shelterin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of shelterin complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
telomeric repeat-binding factor 2-interacting protein 1
Names
RAP1 homolog
TERF2-interacting telomeric protein 1
TRF2-interacting telomeric protein 1
TRF2-interacting telomeric protein Rap1
repressor/activator protein 1 homolog

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020584.2NP_065609.2  telomeric repeat-binding factor 2-interacting protein 1

    See identical proteins and their annotated locations for NP_065609.2

    Status: VALIDATED

    Source sequence(s)
    AK148508, AK148537, BY129872
    Consensus CDS
    CCDS52678.1
    UniProtKB/Swiss-Prot
    D3YWE8, Q543F4, Q8C2Y1, Q91VL8, Q9JJE8, Q9JJE9
    Related
    ENSMUSP00000052170.9, ENSMUST00000052138.11
    Conserved Domains (3) summary
    pfam08914
    Location:129193
    Myb_DNA-bind_2; Rap1 Myb domain
    pfam16589
    Location:17100
    BRCT_2; BRCT domain, a BRCA1 C-terminus domain
    cl13131
    Location:300393
    rap1_RCT; C-terminal domain of RAP1 recruits proteins to telomeres

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    112737991..112747160
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)