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Srsf4 serine and arginine-rich splicing factor 4 [ Mus musculus (house mouse) ]

Gene ID: 57317, updated on 12-May-2024

Summary

Official Symbol
Srsf4provided by MGI
Official Full Name
serine and arginine-rich splicing factor 4provided by MGI
Primary source
MGI:MGI:1890577
See related
Ensembl:ENSMUSG00000028911 AllianceGenome:MGI:1890577
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SRp75; Sfrs4; MNCb-2616; 5730499P16Rik
Summary
The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. [provided by RefSeq, Sep 2010]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 39.5), CNS E14 (RPKM 24.9) and 28 other tissues See more
Orthologs
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Genomic context

See Srsf4 in Genome Data Viewer
Location:
4 D2.3; 4 64.53 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (131600841..131629036)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (131873530..131901725)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase receptor type U Neighboring gene predicted gene, 52680 Neighboring gene STARR-positive B cell enhancer ABC_E10262 Neighboring gene mitochondrial trans-2-enoyl-CoA reductase Neighboring gene predicted gene 12992 Neighboring gene phosphatidylinositol 3-kinase, catalytic, beta polypeptide pseudogene Neighboring gene transmembrane protein 200B Neighboring gene erythrocyte membrane protein band 4.1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables sequence-specific mRNA binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
serine/arginine-rich splicing factor 4
Names
splicing factor, arginine/serine-rich 4 (SRp75)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001369308.1NP_001356237.1  serine/arginine-rich splicing factor 4 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1-4 all encode the same isoform (a).
    Source sequence(s)
    AL607088
    Conserved Domains (3) summary
    cd12600
    Location:109180
    RRM2_SRSF4_like; RNA recognition motif 2 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
    TIGR01642
    Location:250361
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    cl17169
    Location:4277
    RRM_SF; RNA recognition motif (RRM) superfamily
  2. NM_001369309.1NP_001356238.1  serine/arginine-rich splicing factor 4 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same isoform (a).
    Source sequence(s)
    AL607088
    Conserved Domains (3) summary
    cd12600
    Location:109180
    RRM2_SRSF4_like; RNA recognition motif 2 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
    TIGR01642
    Location:250361
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    cl17169
    Location:4277
    RRM_SF; RNA recognition motif (RRM) superfamily
  3. NM_001369310.1NP_001356239.1  serine/arginine-rich splicing factor 4 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same isoform (a).
    Source sequence(s)
    AL607088
    Conserved Domains (3) summary
    cd12600
    Location:109180
    RRM2_SRSF4_like; RNA recognition motif 2 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
    TIGR01642
    Location:250361
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    cl17169
    Location:4277
    RRM_SF; RNA recognition motif (RRM) superfamily
  4. NM_001369311.1NP_001356240.1  serine/arginine-rich splicing factor 4 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same isoform (a).
    Source sequence(s)
    AL607088
    Conserved Domains (3) summary
    cd12600
    Location:109180
    RRM2_SRSF4_like; RNA recognition motif 2 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
    TIGR01642
    Location:250361
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    cl17169
    Location:4277
    RRM_SF; RNA recognition motif (RRM) superfamily
  5. NM_001369312.1NP_001356241.1  serine/arginine-rich splicing factor 4 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AL607088
    Conserved Domains (2) summary
    cd12600
    Location:29100
    RRM2_SRSF4_like; RNA recognition motif 2 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
    TIGR01642
    Location:170281
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
  6. NM_020587.2NP_065612.2  serine/arginine-rich splicing factor 4 isoform b

    See identical proteins and their annotated locations for NP_065612.2

    Status: REVIEWED

    Source sequence(s)
    AK075769, AK077648, AV016063, BY107258
    Consensus CDS
    CCDS51315.1
    UniProtKB/TrEMBL
    Q542V3
    Related
    ENSMUSP00000061474.4, ENSMUST00000053819.6
    Conserved Domains (2) summary
    cd12337
    Location:372
    RRM1_SRSF4_like; RNA recognition motif 1 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
    cd12600
    Location:104175
    RRM2_SRSF4_like; RNA recognition motif 2 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    131600841..131629036
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017320335.2XP_017175824.1  serine/arginine-rich splicing factor 4 isoform X2

    Conserved Domains (2) summary
    TIGR01642
    Location:122234
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    cl17169
    Location:152
    RRM_SF; RNA recognition motif (RRM) superfamily
  2. XM_036164281.1XP_036020174.1  serine/arginine-rich splicing factor 4 isoform X2

    Conserved Domains (2) summary
    TIGR01642
    Location:122234
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    cl17169
    Location:152
    RRM_SF; RNA recognition motif (RRM) superfamily
  3. XM_017320333.3XP_017175822.1  serine/arginine-rich splicing factor 4 isoform X1

    Conserved Domains (3) summary
    cd12600
    Location:109180
    RRM2_SRSF4_like; RNA recognition motif 2 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
    TIGR01642
    Location:250361
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    cl17169
    Location:4277
    RRM_SF; RNA recognition motif (RRM) superfamily
  4. XM_030253687.2XP_030109547.1  serine/arginine-rich splicing factor 4 isoform X2

    Conserved Domains (2) summary
    TIGR01642
    Location:122234
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    cl17169
    Location:152
    RRM_SF; RNA recognition motif (RRM) superfamily
  5. XM_036164282.1XP_036020175.1  serine/arginine-rich splicing factor 4 isoform X2

    Conserved Domains (2) summary
    TIGR01642
    Location:122234
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    cl17169
    Location:152
    RRM_SF; RNA recognition motif (RRM) superfamily