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Gstm3 glutathione S-transferase mu 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 57298, updated on 23-Nov-2023

Summary

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Symbol
Gstm3provided by RGD
Full Name
glutathione S-transferase mu 3provided by RGD
Primary source
RGD:620381
See related
Ensembl:ENSRNOG00000019058 AllianceGenome:RGD:620381
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gstm4; GstYb4; Gstm3l; Gstm3l1
Summary
Predicted to enable glutathione transferase activity and identical protein binding activity. Predicted to be involved in glutathione metabolic process. Predicted to be located in cytosol and intercellular bridge. Orthologous to human GSTM5 (glutathione S-transferase mu 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 149.2), Testes (RPKM 106.0) and 7 other tissues See more
Orthologs
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Genomic context

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See Gstm3 in Genome Data Viewer
Location:
2q34
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_06 current mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (195590450..195612578, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (210761729..210766501, complement)

Chromosome 2 - NC_051337.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100916 Neighboring gene glutathione S-transferase, mu 7 Neighboring gene glutathione S-transferase, mu 6 Neighboring gene glutathione S-transferase mu 3 like 1 Neighboring gene uncharacterized LOC102550192 Neighboring gene glutathione S-transferase mu 2 Neighboring gene glutathione S-transferase mu 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Expression profiling identifies genes involved in emphysema severity. Francis SM, et al. Respir Res, 2009 Sep 2. PMID 19723343, Free PMC Article
  2. Proteomic analysis of peripheral T-lymphocytes in patients with asthma. Jeong HC, et al. Chest, 2007 Aug. PMID 17550934
  3. Glutathione S-transferase GSTM3 and GSTP1 genotypes and larynx cancer risk. Jourenkova-Mironova N, et al. Cancer Epidemiol Biomarkers Prev, 1999 Feb. PMID 10067818
  4. Gene expression of rat glutathione S-transferases. Evidence for gene conversion in the evolution of the Yb multigene family. Lai HC, et al. J Biol Chem, 1988 Aug 15. PMID 3403534
  5. Glutathione S-transferase hGSTM3 and ageing-associated neurodegeneration: relationship to Alzheimer's disease. Tchaikovskaya T, et al. Mech Ageing Dev, 2005 Feb. PMID 15621212

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cellular response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in glutathione metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to bacterium ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
glutathione S-transferase Mu 3
Names
glutathione S-transferase M3
glutathione S-transferase M4
glutathione S-transferase Yb4
glutathione S-transferase mu 3-like 1
NP_065415.2
XP_038958929.1
XP_038958930.1
XP_038958931.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020540.2 → NP_065415.2  glutathione S-transferase Mu 3

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000077
    UniProtKB/TrEMBL
    A6HUW7, D3ZVQ8, Q9WU21
    Related
    ENSRNOP00000044720.6, ENSRNOT00000051261.7

RefSeqs of Annotated Genomes: GCF_015227675.2-RS_2023_06

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051337.1 Reference mRatBN7.2 Primary Assembly

    Range
    195590450..195612578 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039103001.1 → XP_038958929.1  glutathione S-transferase Mu 3 isoform X1

    UniProtKB/TrEMBL
    Q9WU21
    Conserved Domains (2) summary
    cd03209
    Location:92 → 212
    GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
    cd03075
    Location:3 → 84
    GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

  2. XM_039103003.1 → XP_038958931.1  glutathione S-transferase Mu 3 isoform X3

    Conserved Domains (1) summary
    cl02776
    Location:13 → 104
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

  3. XM_039103002.1 → XP_038958930.1  glutathione S-transferase Mu 3 isoform X2

    Conserved Domains (2) summary
    cd03075
    Location:3 → 84
    GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
    cl02776
    Location:92 → 120
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

RNA

  1. XR_005500356.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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