U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Gstm3 glutathione S-transferase mu 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 57298, updated on 7-Apr-2025

Summary

Go to the top of the page Help
Symbol
Gstm3provided by RGD
Full Name
glutathione S-transferase mu 3provided by RGD
Primary source
RGD:620381
See related
EnsemblRapid:ENSRNOG00000019058 AllianceGenome:RGD:620381
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gstm4; GstYb4; Gstm3l; Gstm3l1
Summary
Predicted to enable glutathione transferase activity and identical protein binding activity. Predicted to act upstream of or within cellular response to organic cyclic compound; cellular response to xenobiotic stimulus; and response to bacterium. Predicted to be located in cytoplasm. Biomarker of hypertension. Human ortholog(s) of this gene implicated in uterine fibroid. Orthologous to human GSTM5 (glutathione S-transferase mu 5). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Biased expression in Liver (RPKM 149.2), Testes (RPKM 106.0) and 7 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Gstm3 in Genome Data Viewer
Location:
2q34
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (198295442..198300742, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (195590450..195612578, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (210761729..210766501, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase mu 3 like 1 Neighboring gene uncharacterized LOC102550192 Neighboring gene glutathione S-transferase mu 2 Neighboring gene glutathione S-transferase mu 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Gene expression of rat glutathione S-transferases. Evidence for gene conversion in the evolution of the Yb multigene family. Lai HC, et al. J Biol Chem, 1988 Aug 15. PMID 3403534
  2. Glutathione S-transferase GSTM3 and GSTP1 genotypes and larynx cancer risk. Jourenkova-Mironova N, et al. Cancer Epidemiol Biomarkers Prev, 1999 Feb. PMID 10067818
  3. Expression profiling identifies genes involved in emphysema severity. Francis SM, et al. Respir Res, 2009 Sep 2. PMID 19723343, Free PMC Article
  4. Proteomic analysis of peripheral T-lymphocytes in patients with asthma. Jeong HC, et al. Chest, 2007 Aug. PMID 17550934
  5. Glutathione S-transferase hGSTM3 and ageing-associated neurodegeneration: relationship to Alzheimer's disease. Tchaikovskaya T, et al. Mech Ageing Dev, 2005 Feb. PMID 15621212

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables glutathione transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to bacterium ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
glutathione S-transferase Mu 3
Names
glutathione S-transferase M3
glutathione S-transferase M4
glutathione S-transferase Yb4
glutathione S-transferase mu 3-like 1
NP_065415.2
XP_038958931.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020540.2 → NP_065415.2  glutathione S-transferase Mu 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A6HUW7, D3ZVQ8, Q9WU21
    Related
    ENSRNOP00000044720.6, ENSRNOT00000051261.9

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    198295442..198300742 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039103003.2 → XP_038958931.1  glutathione S-transferase Mu 3 isoform X1

    Conserved Domains (1) summary
    cl02776
    Location:13 → 104
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

RNA

  1. XR_005500356.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools