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PTGDR prostaglandin D2 receptor [ Homo sapiens (human) ]

Gene ID: 5729, updated on 23-Aug-2020

Summary

Official Symbol
PTGDRprovided by HGNC
Official Full Name
prostaglandin D2 receptorprovided by HGNC
Primary source
HGNC:HGNC:9591
See related
Ensembl:ENSG00000168229 MIM:604687
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DP; AS1; DP1; ASRT1; PTGDR1
Summary
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein is reported to be a receptor for prostaglandin D2, which is a mediator of allergic inflammation and allergic airway inflammation in asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Expression
Broad expression in spleen (RPKM 1.6), colon (RPKM 1.3) and 19 other tissues See more
Orthologs

Genomic context

See PTGDR in Genome Data Viewer
Location:
14q22.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (52267256..52276724)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (52734310..52743808)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene CAGE-defined high expression enhancer upstream of NID2 Neighboring gene long intergenic non-protein coding RNA 2319 Neighboring gene cytochrome c oxidase subunit 5A pseudogene 2 Neighboring gene pumilio domain-containing protein KIAA0020-like Neighboring gene prostaglandin E receptor 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Asthma-related traits, susceptibility to, 1
MedGen: C1846534 OMIM: 607277 GeneReviews: Not available
Compare labs
Genome-wide association studies and epistasis analyses of candidate genes related to age at menarche and age at natural menopause in a Korean population.
GeneReviews: Not available
Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.
GeneReviews: Not available
Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC49004

Gene Ontology Provided by GOA

Function Evidence Code Pubs
prostaglandin D receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
prostaglandin D receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
prostaglandin J receptor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
adenosine metabolic process IEA
Inferred from Electronic Annotation
more info
 
cellular response to prostaglandin D stimulus IEA
Inferred from Electronic Annotation
more info
 
inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
male sex determination IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sleep IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
prostaglandin D2 receptor
Names
PGD2 receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012118.1 RefSeqGene

    Range
    4986..14012
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000953.3NP_000944.1  prostaglandin D2 receptor isoform 1

    See identical proteins and their annotated locations for NP_000944.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK026202, AL365475, BC040968
    Consensus CDS
    CCDS9707.1
    UniProtKB/Swiss-Prot
    Q13258
    Related
    ENSP00000303424.2, ENST00000306051.3
    Conserved Domains (1) summary
    cd15140
    Location:17335
    7tmA_PGD2; prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001281469.2NP_001268398.1  prostaglandin D2 receptor isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon, which results in a frameshift, compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK026202, AL365475, CD013871
    Consensus CDS
    CCDS61454.1
    UniProtKB/Swiss-Prot
    Q13258
    Related
    ENSP00000452408.1, ENST00000553372.1
    Conserved Domains (1) summary
    pfam00001
    Location:59214
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    52267256..52276724
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005267891.4XP_005267948.1  prostaglandin D2 receptor isoform X1

    See identical proteins and their annotated locations for XP_005267948.1

    UniProtKB/Swiss-Prot
    Q13258
    Conserved Domains (1) summary
    cd15140
    Location:17335
    7tmA_PGD2; prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
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