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PTGDR prostaglandin D2 receptor [ Homo sapiens (human) ]

Gene ID: 5729, updated on 12-Oct-2019

Summary

Official Symbol
PTGDRprovided by HGNC
Official Full Name
prostaglandin D2 receptorprovided by HGNC
Primary source
HGNC:HGNC:9591
See related
Ensembl:ENSG00000168229 MIM:604687
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DP; AS1; DP1; ASRT1; PTGDR1
Summary
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein is reported to be a receptor for prostaglandin D2, which is a mediator of allergic inflammation and allergic airway inflammation in asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Expression
Broad expression in spleen (RPKM 1.6), colon (RPKM 1.3) and 19 other tissues See more
Orthologs

Genomic context

See PTGDR in Genome Data Viewer
Location:
14q22.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (52267256..52276724)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (52734310..52743808)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene CAGE-defined high expression enhancer upstream of NID2 Neighboring gene long intergenic non-protein coding RNA 2319 Neighboring gene cytochrome c oxidase subunit 5A pseudogene 2 Neighboring gene pumilio domain-containing protein KIAA0020-like Neighboring gene prostaglandin E receptor 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Asthma-related traits, susceptibility to, 1
MedGen: C1846534 OMIM: 607277 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Genome-wide association studies and epistasis analyses of candidate genes related to age at menarche and age at natural menopause in a Korean population.
NHGRI GWA Catalog
Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.
NHGRI GWA Catalog
Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
NHGRI GWA Catalog

Pathways from BioSystems

  • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
    Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
  • Eicosanoid ligand-binding receptors, organism-specific biosystem (from REACTOME)
    Eicosanoid ligand-binding receptors, organism-specific biosystemEicosanoids, derived from polyunsaturated 20-carbon fatty acids, are paracrine and autocrine regulators of inflammation, smooth muscle contraction, and blood coagulation. The actions of eicosanoids a...
  • G alpha (s) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (s) signalling events, organism-specific biosystemThe general function of the G alpha (s) subunit (Gs) is to activate adenylate cyclase, which in turn produces cAMP, leading to the activation of cAMP-dependent protein kinases (often referred to col...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
    GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
  • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, organism-specific biosystem
    Neuroactive ligand-receptor interaction
  • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, conserved biosystem
    Neuroactive ligand-receptor interaction
  • Prostaglandin Synthesis and Regulation, organism-specific biosystem (from WikiPathways)
    Prostaglandin Synthesis and Regulation, organism-specific biosystemA prostaglandin is any member of a group of lipid compounds that are derived enzymatically from fatty acids and have important functions in the animal body. Every prostaglandin contains 20 carbon ato...
  • Prostanoid ligand receptors, organism-specific biosystem (from REACTOME)
    Prostanoid ligand receptors, organism-specific biosystemFatty acid cyclo-oxygenase (COX) converts arachidonic acid to prostaglandin H2 (PGH2) from which the prostanoids PGD2, PGE2, PGF2alpha, PGI2 (prostacyclin) and thromboxane A2 (TXA2) are derived. Base...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
  • Small Ligand GPCRs, organism-specific biosystem (from WikiPathways)
    Small Ligand GPCRs, organism-specific biosystem
    Small Ligand GPCRs
  • Thromboxane A2 receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
    Thromboxane A2 receptor signaling, organism-specific biosystem
    Thromboxane A2 receptor signaling

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC49004

Gene Ontology Provided by GOA

Function Evidence Code Pubs
prostaglandin D receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
prostaglandin D receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
prostaglandin J receptor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
adenosine metabolic process IEA
Inferred from Electronic Annotation
more info
 
NOT adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to prostaglandin D stimulus IEA
Inferred from Electronic Annotation
more info
 
inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
male sex determination IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sleep IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
prostaglandin D2 receptor
Names
PGD2 receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012118.1 RefSeqGene

    Range
    4986..14012
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000953.3NP_000944.1  prostaglandin D2 receptor isoform 1

    See identical proteins and their annotated locations for NP_000944.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK026202, AL365475, BC040968
    Consensus CDS
    CCDS9707.1
    UniProtKB/Swiss-Prot
    Q13258
    Related
    ENSP00000303424.2, ENST00000306051.3
    Conserved Domains (1) summary
    cd15140
    Location:17335
    7tmA_PGD2; prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001281469.2NP_001268398.1  prostaglandin D2 receptor isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon, which results in a frameshift, compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK026202, AL365475, CD013871
    Consensus CDS
    CCDS61454.1
    UniProtKB/Swiss-Prot
    Q13258
    Related
    ENSP00000452408.1, ENST00000553372.1
    Conserved Domains (1) summary
    pfam00001
    Location:59214
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    52267256..52276724
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005267891.4XP_005267948.1  prostaglandin D2 receptor isoform X1

    See identical proteins and their annotated locations for XP_005267948.1

    UniProtKB/Swiss-Prot
    Q13258
    Conserved Domains (1) summary
    cd15140
    Location:17335
    7tmA_PGD2; prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
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