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Apba3 amyloid beta precursor protein binding family A member 3 [ Mus musculus (house mouse) ]

Gene ID: 57267, updated on 12-May-2024

Summary

Official Symbol
Apba3provided by MGI
Official Full Name
amyloid beta precursor protein binding family A member 3provided by MGI
Primary source
MGI:MGI:1888527
See related
Ensembl:ENSMUSG00000004931 AllianceGenome:MGI:1888527
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mint3; Mint-3; lin-10; X11gamma
Summary
Predicted to enable amyloid-beta binding activity; enzyme binding activity; and enzyme inhibitor activity. Acts upstream of or within chemical synaptic transmission; in utero embryonic development; and regulation of gene expression. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in cytoplasm; dendritic spine; and plasma membrane. Orthologous to human APBA3 (amyloid beta precursor protein binding family A member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 37.3), duodenum adult (RPKM 34.9) and 28 other tissues See more
Orthologs
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Genomic context

See Apba3 in Genome Data Viewer
Location:
10 C1; 10 39.72 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (81102799..81109081)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (81266935..81273247)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene megakaryocyte-associated tyrosine kinase Neighboring gene STARR-positive B cell enhancer ABC_E6886 Neighboring gene mitochondrial ribosomal protein L54 Neighboring gene microRNA 3057 Neighboring gene tight junction protein 3 Neighboring gene STARR-seq mESC enhancer starr_27326 Neighboring gene STARR-positive B cell enhancer ABC_E301 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:80760144-80760253 Neighboring gene phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:80760802-80760911 Neighboring gene predicted gene 16315 Neighboring gene cactin, spliceosome C complex subunit

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (4)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables amyloid-beta binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables amyloid-beta binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in dendritic spine IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
amyloid-beta A4 precursor protein-binding family A member 3
Names
Mint 3
adapter protein X11gamma
amyloid beta (A4) precursor protein-binding, family A, member 3
neuron-specific X11L2 protein
neuronal munc18-1-interacting protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429264.1NP_001416193.1  amyloid-beta A4 precursor protein-binding family A member 3 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC155932
  2. NM_001429265.1NP_001416194.1  amyloid-beta A4 precursor protein-binding family A member 3 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC155932
  3. NM_001429266.1NP_001416195.1  amyloid-beta A4 precursor protein-binding family A member 3 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC155932
  4. NM_001429267.1NP_001416196.1  amyloid-beta A4 precursor protein-binding family A member 3 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC155932
  5. NM_018758.3NP_061228.1  amyloid-beta A4 precursor protein-binding family A member 3 isoform a

    See identical proteins and their annotated locations for NP_061228.1

    Status: VALIDATED

    Source sequence(s)
    AC155932
    Consensus CDS
    CCDS24050.1
    UniProtKB/Swiss-Prot
    O88888, Q3TDI1, Q8BR09
    UniProtKB/TrEMBL
    Q8BNM8
    Related
    ENSMUSP00000050995.9, ENSMUST00000057798.9
    Conserved Domains (2) summary
    cd00992
    Location:480548
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01208
    Location:209361
    PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain

RNA

  1. NR_190703.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC155932
  2. NR_190704.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC155932
  3. NR_190705.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC155932

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    81102799..81109081
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513905.1XP_006513968.1  amyloid-beta A4 precursor protein-binding family A member 3 isoform X1

    See identical proteins and their annotated locations for XP_006513968.1

    UniProtKB/Swiss-Prot
    O88888, Q3TDI1, Q8BR09
    UniProtKB/TrEMBL
    Q8BNM8
    Related
    ENSMUSP00000151985.2, ENSMUST00000220297.2
    Conserved Domains (2) summary
    cd00992
    Location:480548
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01208
    Location:209361
    PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain
  2. XM_006513907.5XP_006513970.1  amyloid-beta A4 precursor protein-binding family A member 3 isoform X2

    UniProtKB/TrEMBL
    Q8BNM8
    Conserved Domains (2) summary
    cd00992
    Location:471539
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01208
    Location:209352
    PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain
  3. XM_006513906.5XP_006513969.1  amyloid-beta A4 precursor protein-binding family A member 3 isoform X1

    UniProtKB/Swiss-Prot
    O88888, Q3TDI1, Q8BR09
    UniProtKB/TrEMBL
    Q8BNM8
    Conserved Domains (2) summary
    cd00992
    Location:480548
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01208
    Location:209361
    PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain
  4. XM_036155901.1XP_036011794.1  amyloid-beta A4 precursor protein-binding family A member 3 isoform X1

    UniProtKB/Swiss-Prot
    O88888, Q3TDI1, Q8BR09
    UniProtKB/TrEMBL
    Q8BNM8
    Conserved Domains (2) summary
    cd00992
    Location:480548
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01208
    Location:209361
    PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain