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Vav3 vav 3 oncogene [ Mus musculus (house mouse) ]

Gene ID: 57257, updated on 16-Oct-2021

Summary

Official Symbol
Vav3provided by MGI
Official Full Name
vav 3 oncogeneprovided by MGI
Primary source
MGI:MGI:1888518
See related
Ensembl:ENSMUSG00000033721
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Idd18.1; AA986410; A530094I06Rik
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 2.7), CNS E14 (RPKM 2.5) and 27 other tissues See more
Orthologs
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Genomic context

See Vav3 in Genome Data Viewer
Location:
3; 3 F3
Exon count:
28
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (109247757..109593010)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (109340465..109685694)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (109143601..109488612)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 24 Neighboring gene zona pellucida binding protein 2 pseudogene Neighboring gene netrin G1 Neighboring gene predicted gene, 25681 Neighboring gene predicted gene, 54214

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC27838

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables epidermal growth factor receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables guanyl-nucleotide exchange factor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables guanyl-nucleotide exchange factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in B cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within angiogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cell projection assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within integrin-mediated signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lamellipodium assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within neutrophil chemotaxis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of B cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell adhesion IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of GTPase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within small GTPase mediated signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within vesicle fusion IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in immunological synapse ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
guanine nucleotide exchange factor VAV3
Names
VAV-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001378987.1NP_001365916.1  guanine nucleotide exchange factor VAV3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL671857, AL671987, AL731716
    Conserved Domains (7) summary
    cd10407
    Location:666768
    SH2_Vav3; Src homology 2 (SH2) domain found in the Vav3 proteins
    cd11978
    Location:819874
    SH3_VAV3_2; C-terminal (or second) Src homology 3 domain of VAV3 protein
    cd11981
    Location:596657
    SH3_VAV3_1; First Src homology 3 domain of VAV3 protein
    cd00160
    Location:193369
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:383506
    PH_Vav; Vav pleckstrin homology (PH) domain
    cd21264
    Location:2118
    CH_VAV3; calponin homology (CH) domain found in VAV3 protein and similar proteins
    cd20869
    Location:506564
    C1_VAV3; protein kinase C conserved region 1 (C1 domain) found in VAV3 protein
  2. NM_020505.2NP_065251.2  guanine nucleotide exchange factor VAV3 isoform 1

    See identical proteins and their annotated locations for NP_065251.2

    Status: VALIDATED

    Source sequence(s)
    AF067816, AK033253, BC052739
    Consensus CDS
    CCDS17773.1
    UniProtKB/Swiss-Prot
    Q9R0C8
    Related
    ENSMUSP00000036270.8, ENSMUST00000046864.14
    Conserved Domains (8) summary
    cd10407
    Location:666768
    SH2_Vav3; Src homology 2 (SH2) domain found in the Vav3 proteins
    cd11978
    Location:791846
    SH3_VAV3_2; C-terminal (or second) Src homology 3 domain of VAV3 protein
    cd11981
    Location:596657
    SH3_VAV3_1; First Src homology 3 domain of VAV3 protein
    cd00029
    Location:514561
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:193369
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:383506
    PH_Vav; Vav pleckstrin homology (PH) domain
    pfam00169
    Location:407502
    PH; PH domain
    pfam11971
    Location:18103
    CAMSAP_CH; CAMSAP CH domain
  3. NM_146139.2NP_666251.1  guanine nucleotide exchange factor VAV3 isoform 2

    See identical proteins and their annotated locations for NP_666251.1

    Status: VALIDATED

    Source sequence(s)
    AF140280, BC052739
    Consensus CDS
    CCDS59650.1
    UniProtKB/Swiss-Prot
    Q9R0C8
    Related
    ENSMUSP00000102186.3, ENSMUST00000106576.3
    Conserved Domains (3) summary
    cd10407
    Location:106208
    SH2_Vav3; Src homology 2 (SH2) domain found in the Vav3 proteins
    cd11978
    Location:231286
    SH3_VAV3_2; C-terminal (or second) Src homology 3 domain of VAV3 protein
    cd11981
    Location:3697
    SH3_VAV3_1; First Src homology 3 domain of VAV3 protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    109247757..109593010
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501820.5XP_006501883.1  guanine nucleotide exchange factor VAV3 isoform X1

    See identical proteins and their annotated locations for XP_006501883.1

    Conserved Domains (7) summary
    cd10407
    Location:642744
    SH2_Vav3; Src homology 2 (SH2) domain found in the Vav3 proteins
    cd11978
    Location:795850
    SH3_VAV3_2; C-terminal (or second) Src homology 3 domain of VAV3 protein
    cd11981
    Location:572633
    SH3_VAV3_1; First Src homology 3 domain of VAV3 protein
    cd00029
    Location:514561
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:193369
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:383506
    PH_Vav; Vav pleckstrin homology (PH) domain
    pfam11971
    Location:18103
    CAMSAP_CH; CAMSAP CH domain
  2. XM_036163196.1XP_036019089.1  guanine nucleotide exchange factor VAV3 isoform X2

    Conserved Domains (7) summary
    cd10407
    Location:642744
    SH2_Vav3; Src homology 2 (SH2) domain found in the Vav3 proteins
    cd11978
    Location:767822
    SH3_VAV3_2; C-terminal (or second) Src homology 3 domain of VAV3 protein
    cd11981
    Location:572633
    SH3_VAV3_1; First Src homology 3 domain of VAV3 protein
    cd00160
    Location:193369
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:383506
    PH_Vav; Vav pleckstrin homology (PH) domain
    cd21264
    Location:2118
    CH_VAV3; calponin homology (CH) domain found in VAV3 protein and similar proteins
    cd20869
    Location:506564
    C1_VAV3; protein kinase C conserved region 1 (C1 domain) found in VAV3 protein
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