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gins4 GINS complex subunit 4 (Sld5 homolog) [ Danio rerio (zebrafish) ]

Gene ID: 572562, updated on 9-Sep-2025
Official Symbol
gins4provided by ZNC
Official Full Name
GINS complex subunit 4 (Sld5 homolog)provided by ZNC
Primary source
ZFIN:ZDB-GENE-040801-59
See related
Ensembl:ENSDARG00000016044 AllianceGenome:ZFIN:ZDB-GENE-040801-59
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
im:7137690; zgc:100817
Summary
Predicted to be involved in double-strand break repair via break-induced replication. Predicted to act upstream of or within DNA-templated DNA replication. Predicted to be located in nucleus. Predicted to be part of GINS complex. Orthologous to human GINS4 (GINS complex subunit 4). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
human mouse all
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See gins4 in Genome Data Viewer
Location:
chromosome: 8
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 8 NC_133183.1 (62247938..62263893)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 8 NC_007119.7 (52415574..52431522)

Chromosome 8 - NC_133183.1Genomic Context describing neighboring genes Neighboring gene AT-rich interactive domain 5A Neighboring gene cytochrome c oxidase subunit 5Bb Neighboring gene protein phosphatase 1 regulatory subunit 3C2, duplicate b Neighboring gene phytanoyl-CoA 2-hydroxylase interacting protein

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Zebrafish macrophage developmental arrest underlies depletion of microglia and reveals Csf1r-independent metaphocytes. Kuil LE, et al. Elife, 2020 May 5. PMID 32367800, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Clone Names

  • MGC100817, MGC158574

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA-templated DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair via break-induced replication IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of GINS complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of GINS complex IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
DNA replication complex GINS protein SLD5

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003546.2 → NP_001003546.2  DNA replication complex GINS protein SLD5

    Status: VALIDATED

    Source sequence(s)
    EE697537, EH534241, EH566551
    UniProtKB/TrEMBL
    A0A2R8Q9M1, A0A8M1N188
    Related
    ENSDARP00000151126.1, ENSDART00000191424.1
    Conserved Domains (3) summary
    cd11711
    Location:20 → 140
    GINS_A_Sld5; Alpha-helical domain of GINS complex protein Sld5
    COG5086
    Location:17 → 217
    COG5086; Uncharacterized conserved protein [Function unknown]
    pfam16922
    Location:159 → 217
    SLD5_C; DNA replication complex GINS protein SLD5 C-terminus

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133183.1 Reference GRCz12tu Primary Assembly

    Range
    62247938..62263893
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021478305.3 → XP_021333980.1  DNA replication complex GINS protein SLD5 isoform X2

    UniProtKB/TrEMBL
    A0A8M9QIP2
    Conserved Domains (2) summary
    cd11711
    Location:20 → 140
    GINS_A_Sld5; Alpha-helical domain of GINS complex protein Sld5
    pfam16922
    Location:159 → 201
    SLD5_C; DNA replication complex GINS protein SLD5 C-terminus

  2. XM_073909773.1 → XP_073765874.1  DNA replication complex GINS protein SLD5 isoform X1

Nucleotide Protein Strain
Heading Accession and Version

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