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PGM5-AS1 PGM5 antisense RNA 1 [ Homo sapiens (human) ]

Gene ID: 572558, updated on 4-Sep-2022

Summary

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Official Symbol
PGM5-AS1provided by HGNC
Official Full Name
PGM5 antisense RNA 1provided by HGNC
Primary source
HGNC:HGNC:44181
See related
Ensembl:ENSG00000224958 AllianceGenome:HGNC:44181
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM233A
Expression
Biased expression in prostate (RPKM 31.6), endometrium (RPKM 17.6) and 4 other tissues See more
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Genomic context

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See PGM5-AS1 in Genome Data Viewer
Location:
9q21.11
Exon count:
3
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (68355164..68357866, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (80528761..80531472, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (70970080..70972782, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929800 Neighboring gene uncharacterized LOC102723624 Neighboring gene phosphoglucomutase 5 Neighboring gene uncharacterized LOC105376070 Neighboring gene uncharacterized LOC124902174

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Down-regulation of long noncoding RNA PGM5-AS1 correlates with tumor progression and predicts poor prognosis in clear cell renal cell carcinoma. Qian M, et al. Eur Rev Med Pharmacol Sci, 2019 Dec. PMID 31858536
  2. Long non-coding RNAs PGM5-AS1 upregulates Decorin (DCN) to inhibit cervical cancer progression by sponging miR-4284. Wang H, et al. Bioengineered, 2022 Apr. PMID 35420507, Free PMC Article
  3. Circulating lncRNA UCA1 and lncRNA PGM5-AS1 act as potential diagnostic biomarkers for early-stage colorectal cancer. Wang M, et al. Biosci Rep, 2021 Jul 30. PMID 34212174, Free PMC Article
  4. Reduced long noncoding RNA PGM5-AS1 facilitated proliferation and invasion of colorectal cancer through sponging miR-100-5p. Zhou B, et al. Eur Rev Med Pharmacol Sci, 2020 Aug. PMID 32767323
  5. The Downregulation of lncRNA pgm5-as1 Inhibits the Proliferation and Metastasis Via Increasing miR-484 Expression in Colorectal Cancer. Shen Y, et al. Cancer Biother Radiopharm, 2021 Mar. PMID 32354224

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LncRNA PGM5-AS1 Inhibits the Progression of Bladder Cancer by Regulating miR-587/SLIT3 Axis.
    Title: LncRNA PGM5-AS1 Inhibits the Progression of Bladder Cancer by Regulating miR-587/SLIT3 Axis.
  2. Long non-coding RNAs PGM5-AS1 upregulates Decorin (DCN) to inhibit cervical cancer progression by sponging miR-4284.
    Title: Long non-coding RNAs PGM5-AS1 upregulates Decorin (DCN) to inhibit cervical cancer progression by sponging miR-4284.
  3. Circulating lncRNA UCA1 and lncRNA PGM5-AS1 act as potential diagnostic biomarkers for early-stage colorectal cancer.
    Title: Circulating lncRNA UCA1 and lncRNA PGM5-AS1 act as potential diagnostic biomarkers for early-stage colorectal cancer.
  4. The Downregulation of lncRNA pgm5-as1 Inhibits the Proliferation and Metastasis Via Increasing miR-484 Expression in Colorectal Cancer.
    Title: The Downregulation of lncRNA <i>pgm5-as1</i> Inhibits the Proliferation and Metastasis Via Increasing miR-484 Expression in Colorectal Cancer.
  5. Long non-coding RNA PGM5-AS1 promotes epithelial-mesenchymal transition, invasion and metastasis of osteosarcoma cells by impairing miR-140-5p-mediated FBN1 inhibition.
    Title: Long non-coding RNA PGM5-AS1 promotes epithelial-mesenchymal transition, invasion and metastasis of osteosarcoma cells by impairing miR-140-5p-mediated FBN1 inhibition.
  6. Reduced long noncoding RNA PGM5-AS1 facilitated proliferation and invasion of colorectal cancer through sponging miR-100-5p.
    Title: Reduced long noncoding RNA PGM5-AS1 facilitated proliferation and invasion of colorectal cancer through sponging miR-100-5p.
  7. Down-regulation of long noncoding RNA PGM5-AS1 correlates with tumor progression and predicts poor prognosis in clear cell renal cell carcinoma.
    Title: Down-regulation of long noncoding RNA PGM5-AS1 correlates with tumor progression and predicts poor prognosis in clear cell renal cell carcinoma.
  8. our data indicate that PGM5-AS1 is a novel tumor suppressor in esophageal squamous cell carcinoma (ESCC) and restoration of PGM5-AS1 may be a promising avenue for treatment of ESCC patient.
    Title: p53-induced long non-coding RNA PGM5-AS1 inhibits the progression of esophageal squamous cell carcinoma through regulating miR-466/PTEN axis.
  9. High PGM5-AS1 expression levels were associated with worse overall survival in colorectal cancer.
    Title: Identification of key lncRNAs in colorectal cancer progression based on associated protein-protein interaction analysis.
  10. Long non-coding RNA LOC572558 functions as a tumor suppressor and regulates the p53 signaling pathway in bladder cancer.
    Title: Long non-coding RNA LOC572558 inhibits bladder cancer cell proliferation and tumor growth by regulating the AKT-MDM2-p53 signaling axis.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Other Names

  • PGM5 antisense RNA 1 (non-protein coding)
  • family with sequence similarity 233, member A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_015423.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site at the 5' terminal exon, resulting in a shorter transcript, compared to variant 1.
    Source sequence(s)
    AY343894, BC017938, CB051276
    Related
    ENST00000653382.1

  2. NR_121191.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript.
    Source sequence(s)
    BC017938, CB051276

  3. NR_121192.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site at the 5' terminal exon and contains an alternate internal exon, resulting in a shorter transcript, compared to variant 1.
    Source sequence(s)
    AL353608
    Related
    ENST00000420855.6

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    68355164..68357866 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    80528761..80531472 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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Chemical Information
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Research Materials