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PTAFR platelet activating factor receptor [ Homo sapiens (human) ]

Gene ID: 5724, updated on 1-Jun-2020

Summary

Official Symbol
PTAFRprovided by HGNC
Official Full Name
platelet activating factor receptorprovided by HGNC
Primary source
HGNC:HGNC:9582
See related
Ensembl:ENSG00000169403 MIM:173393
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAFR
Summary
This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Expression
Broad expression in appendix (RPKM 15.7), bone marrow (RPKM 12.4) and 19 other tissues See more
Orthologs

Genomic context

See PTAFR in Genome Data Viewer
Location:
1p35.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (28147166..28193936, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (28473677..28520447, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 176, pseudogene Neighboring gene RNA, U7 small nuclear 29 pseudogene Neighboring gene DnaJ heat shock protein family (Hsp40) member C8 Neighboring gene ATP synthase inhibitory factor subunit 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Pre-incubation of podocytes with two platelet-activating factor (PAF) receptor antagonists prevents the loss and redistribution of nephrin induced by Tat, suggesting that PAF is an intracellular mediator of Tat action PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: DNAJC8

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled purinergic nucleotide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor activity TAS
Traceable Author Statement
more info
PubMed 
lipopolysaccharide binding IEA
Inferred from Electronic Annotation
more info
 
lipopolysaccharide receptor activity IEA
Inferred from Electronic Annotation
more info
 
mitogen-activated protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
phospholipid binding IDA
Inferred from Direct Assay
more info
PubMed 
platelet activating factor receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled purinergic nucleotide receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine IEA
Inferred from Electronic Annotation
more info
 
cellular response to cAMP IEA
Inferred from Electronic Annotation
more info
 
cellular response to fatty acid IEA
Inferred from Electronic Annotation
more info
 
cellular response to gravity IEA
Inferred from Electronic Annotation
more info
 
chemotaxis IEA
Inferred from Electronic Annotation
more info
 
cytokine production IEA
Inferred from Electronic Annotation
more info
 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
immune response TAS
Traceable Author Statement
more info
PubMed 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
inositol trisphosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
interferon-gamma-mediated signaling pathway TAS
Traceable Author Statement
more info
 
lipopolysaccharide-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
parturition IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of blood vessel diameter IEA
Inferred from Electronic Annotation
more info
 
positive regulation of gastro-intestinal system smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
 
positive regulation of inositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-6 biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of leukocyte tethering or rolling IEA
Inferred from Electronic Annotation
more info
 
positive regulation of maternal process involved in parturition IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neutrophil degranulation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of phospholipase C activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
positive regulation of smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcytosis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of translation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of tumor necrosis factor production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of vasoconstriction IEA
Inferred from Electronic Annotation
more info
 
positive regulation of voltage-gated chloride channel activity IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
response to dexamethasone IEA
Inferred from Electronic Annotation
more info
 
response to symbiotic bacterium IEA
Inferred from Electronic Annotation
more info
 
transcytosis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
secretory granule membrane TAS
Traceable Author Statement
more info
 
tertiary granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
platelet-activating factor receptor
Names
PAF-R

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029815.1 RefSeqGene

    Range
    5001..51771
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000952.5NP_000943.1  platelet-activating factor receptor

    See identical proteins and their annotated locations for NP_000943.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks the 5' exon, but has an alternate 5' segment, as compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    AL137792, BC063000, DA923972
    Consensus CDS
    CCDS318.1
    UniProtKB/Swiss-Prot
    P25105
    Related
    ENSP00000362965.3, ENST00000373857.8
    Conserved Domains (1) summary
    cd15147
    Location:16304
    7tmA_PAFR; platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001164721.1NP_001158193.1  platelet-activating factor receptor

    See identical proteins and their annotated locations for NP_001158193.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is composed of three exons. Variants 1-4 encode the same protein.
    Source sequence(s)
    AK292053, AL137792, BC063000, DA705644
    Consensus CDS
    CCDS318.1
    UniProtKB/Swiss-Prot
    P25105
    UniProtKB/TrEMBL
    A8K7N8
    Related
    ENSP00000442658.1, ENST00000539896.1
    Conserved Domains (1) summary
    cd15147
    Location:16304
    7tmA_PAFR; platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. NM_001164722.3NP_001158194.1  platelet-activating factor receptor

    See identical proteins and their annotated locations for NP_001158194.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an internal 5' UTR exon, as compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    AL137792, DA705644
    Consensus CDS
    CCDS318.1
    UniProtKB/Swiss-Prot
    P25105
    UniProtKB/TrEMBL
    A8K7N8
    Related
    ENSP00000301974.3, ENST00000305392.3
    Conserved Domains (1) summary
    cd15147
    Location:16304
    7tmA_PAFR; platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
  4. NM_001164723.3NP_001158195.1  platelet-activating factor receptor

    See identical proteins and their annotated locations for NP_001158195.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks the 5' exon, but has an additional exon in the 5' region, as compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    AL137792, AL353354, CD013879
    Consensus CDS
    CCDS318.1
    UniProtKB/Swiss-Prot
    P25105
    Conserved Domains (1) summary
    cd15147
    Location:16304
    7tmA_PAFR; platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    28147166..28193936 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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